ID   D2THJ2_CITRI            Unreviewed;       671 AA.
AC   D2THJ2;
DT   02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT   02-MAR-2010, sequence version 1.
DT   27-MAR-2024, entry version 60.
DE   SubName: Full=Efflux pump protein {ECO:0000313|EMBL:CBG88186.1};
GN   OrderedLocusNames=ROD_14231 {ECO:0000313|EMBL:CBG88186.1};
OS   Citrobacter rodentium (strain ICC168) (Citrobacter freundii biotype 4280).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Citrobacter.
OX   NCBI_TaxID=637910 {ECO:0000313|EMBL:CBG88186.1, ECO:0000313|Proteomes:UP000001889};
RN   [1] {ECO:0000313|EMBL:CBG88186.1, ECO:0000313|Proteomes:UP000001889}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ICC168 {ECO:0000313|EMBL:CBG88186.1,
RC   ECO:0000313|Proteomes:UP000001889};
RX   PubMed=19897651; DOI=10.1128/JB.01144-09;
RA   Petty N.K., Bulgin R., Crepin V.F., Cerdeno-Tarraga A.M., Schroeder G.N.,
RA   Quail M.A., Lennard N., Corton C., Barron A., Clark L., Toribio A.L.,
RA   Parkhill J., Dougan G., Frankel G., Thomson N.R.;
RT   "The Citrobacter rodentium genome sequence reveals convergent evolution
RT   with human pathogenic Escherichia coli.";
RL   J. Bacteriol. 192:525-538(2010).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the aromatic acid exporter ArAE (TC 2.A.85)
CC       family. {ECO:0000256|ARBA:ARBA00043989}.
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DR   EMBL; FN543502; CBG88186.1; -; Genomic_DNA.
DR   AlphaFoldDB; D2THJ2; -.
DR   STRING; 637910.ROD_14231; -.
DR   KEGG; cro:ROD_14231; -.
DR   eggNOG; COG1289; Bacteria.
DR   HOGENOM; CLU_013927_3_0_6; -.
DR   OrthoDB; 9807111at2; -.
DR   Proteomes; UP000001889; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR006726; PHBA_efflux_AaeB/fusaric-R.
DR   PANTHER; PTHR30509:SF9; INNER MEMBRANE PROTEIN YCCS; 1.
DR   PANTHER; PTHR30509; P-HYDROXYBENZOIC ACID EFFLUX PUMP SUBUNIT-RELATED; 1.
DR   Pfam; PF04632; FUSC; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        21..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        47..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        72..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        119..137
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        157..183
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        386..405
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        412..432
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        438..455
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        462..484
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        496..515
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   671 AA;  74904 MW;  A2CF70492F212A43 CRC64;
     MTLPRLTLRN TPWLKATAGQ WRYALRNAIA MCLALTFAYY LNLDEPYWAM TSAAVVSFPT
     VGGVISKSLG RIAGSLLGAT AALILAGHTL NEPWLFLLSM SAWIGFCTWA CAHFTNNVAY
     AFQLAGYTAA IIAFPMVNIV EITQLWDIAQ ARVCEVIVGI LCGGTMMMIL PSTSDGVALL
     AALKNMHARL LEHASLLWQP DTTDAIRSAH EGVIGQILTM NLLRIQAFWS HYRFRRQNTL
     LNALLHQQLR LTSVISSLRR MLLNWPAPPP QTRDVIDRLL AALASPQADS YAVAKIIAPL
     APPDGSDFCH VAFWQRLRYF CRLYLQSSRQ LRLLEDGATS AQINVPRAPA LARHTDNAEA
     VWSGVRTFAT LMTIGAWSIG SQWESGSGAL TLAAISCVLY SIVATPFKSL SLLMRTLVLL
     SLFSFVVKFG LMVQISDLWQ FLLFLFPLLT TMQLLKLQMP KLAGLWGQLI VFMGSFIAVT
     NPPVYDFAEF LNDNTAKIVG VALSWLAFAI LRPGSDARKS RRHIRALRRD FVDQLSRRPA
     LSEHEFESLT YHHVSQLSNS QDALARRWLL RWGVVLLNCS HVVWQLRAWE SRSDPLSRVR
     DICITLLRDV MSERGVQQRP LAATLTELLR ICEALSRHHQ PAAQELAAIV WRLYCSLSQL
     EQAPPEGTLT S
//