ID   D2UZA8_NAEGR            Unreviewed;       805 AA.
AC   D2UZA8;
DT   02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT   02-MAR-2010, sequence version 1.
DT   27-MAR-2024, entry version 60.
DE   RecName: Full=Terpene cyclase/mutase family member {ECO:0000256|RuleBase:RU362003};
DE            EC=5.4.99.- {ECO:0000256|RuleBase:RU362003};
GN   ORFNames=NAEGRDRAFT_29622 {ECO:0000313|EMBL:EFC50118.1};
OS   Naegleria gruberi (Amoeba).
OC   Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC   Vahlkampfiidae; Naegleria.
OX   NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN   [1] {ECO:0000313|EMBL:EFC50118.1, ECO:0000313|Proteomes:UP000006671}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NEG-M {ECO:0000313|EMBL:EFC50118.1,
RC   ECO:0000313|Proteomes:UP000006671};
RX   PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA   Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA   Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA   Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA   Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT   "The genome of Naegleria gruberi illuminates early eukaryotic
RT   versatility.";
RL   Cell 140:631-642(2010).
CC   -!- SIMILARITY: Belongs to the terpene cyclase/mutase family.
CC       {ECO:0000256|RuleBase:RU362003}.
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DR   EMBL; GG738846; EFC50118.1; -; Genomic_DNA.
DR   RefSeq; XP_002682862.1; XM_002682816.1.
DR   AlphaFoldDB; D2UZA8; -.
DR   STRING; 5762.D2UZA8; -.
DR   EnsemblProtists; EFC50118; EFC50118; NAEGRDRAFT_29622.
DR   GeneID; 8855310; -.
DR   VEuPathDB; AmoebaDB:NAEGRDRAFT_29622; -.
DR   eggNOG; KOG0497; Eukaryota.
DR   InParanoid; D2UZA8; -.
DR   OMA; CWARQTI; -.
DR   OrthoDB; 2712461at2759; -.
DR   Proteomes; UP000006671; Unassembled WGS sequence.
DR   GO; GO:0005811; C:lipid droplet; IEA:InterPro.
DR   GO; GO:0016866; F:intramolecular transferase activity; IEA:InterPro.
DR   GO; GO:0016104; P:triterpenoid biosynthetic process; IEA:InterPro.
DR   CDD; cd02892; SQCY_1; 1.
DR   Gene3D; 1.50.10.20; -; 2.
DR   InterPro; IPR032696; SQ_cyclase_C.
DR   InterPro; IPR032697; SQ_cyclase_N.
DR   InterPro; IPR018333; Squalene_cyclase.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   NCBIfam; TIGR01787; squalene_cyclas; 1.
DR   PANTHER; PTHR11764:SF20; LANOSTEROL SYNTHASE; 1.
DR   PANTHER; PTHR11764; TERPENE CYCLASE/MUTASE FAMILY MEMBER; 1.
DR   Pfam; PF13243; SQHop_cyclase_C; 1.
DR   Pfam; PF13249; SQHop_cyclase_N; 1.
DR   SFLD; SFLDG01016; Prenyltransferase_Like_2; 1.
DR   SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 2.
PE   3: Inferred from homology;
KW   Isomerase {ECO:0000256|RuleBase:RU362003};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006671};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          132..388
FT                   /note="Squalene cyclase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13249"
FT   DOMAIN          484..796
FT                   /note="Squalene cyclase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13243"
SQ   SEQUENCE   805 AA;  92545 MW;  B7323047C850DB52 CRC64;
     MSINLNKLLE EFKFDSYDYS QSGPIEWRLV VKEGRQRWIP FPQSLLKQSG EEQSNVDKHL
     LNKPSNFEDP ITYINNHPLV VGTTSSNISS TNDDDQATTN ADNDDKLKYI FNKSNNYIIN
     LDEHQVDASI LKAIDFYSSV QTQDGHWAGD YGGPMFLLPG IVIVLYICQK RLPKPFEYEI
     VRYILSKQNQ DGGYGLHIEG HSTIFGTVLN YVALRLLGVS PDHSCMKLTL EFLSKEPANG
     ALGAPQWAKL YLCCLGLMDW DCIDPIPCEL WLLPDWFPYI QPGKWWCHCR VVYLPMAYLY
     GIKKVYANAE TDPIISQLRN ELYDQVSKTS YQNQPWSKYR SYVNPRDNYH PFTQLYSKFA
     SVLTVYEKYI NFSFLRNASL KKCIEHIKYE DSVTNHICIG PVNKVLNMLS VFFSDGSDSE
     LFNKHLDRVY DYLWLSDDGM KFQGYNGSQL WDTAFASQAI CEYYKRFKNQ DNQISCQGSF
     KNEHLNSLLN AYNFINFTQV KEDVPNRMEY YRHQSKGGWP FSTRDHGWPI SDCTAEGLKA
     VLTLYDFDEL ILSEERLTDA VRVILSMFNG GTNGGWATYE LSRTHSWIEI INPAALYGEI
     MIDYPHTECT SACITALLQF KKHFPQSPYV PMIDDSIKHA IKVIEGKQME EGGWYGGWAV
     CFCYGTWFAT TAIVSADPTL NYGNSQALKR GCDFIVAKQM EDGGWGESYL SCVTHRYSHA
     ETSRVISTAW SLLALMTSNY PNLKVIEKGI YCLMRKQLPN GDFPQESISG VFNHNCMITY
     TNYRNIFPIW ALSMYMNKYH SKLVQ
//