ID D2V1T0_NAEGR Unreviewed; 418 AA.
AC D2V1T0;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Predicted protein {ECO:0000313|EMBL:EFC49364.1};
GN ORFNames=NAEGRDRAFT_30302 {ECO:0000313|EMBL:EFC49364.1};
OS Naegleria gruberi (Amoeba).
OC Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC Vahlkampfiidae; Naegleria.
OX NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN [1] {ECO:0000313|EMBL:EFC49364.1, ECO:0000313|Proteomes:UP000006671}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEG-M {ECO:0000313|EMBL:EFC49364.1,
RC ECO:0000313|Proteomes:UP000006671};
RX PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT "The genome of Naegleria gruberi illuminates early eukaryotic
RT versatility.";
RL Cell 140:631-642(2010).
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DR EMBL; GG738848; EFC49364.1; -; Genomic_DNA.
DR RefSeq; XP_002682108.1; XM_002682062.1.
DR AlphaFoldDB; D2V1T0; -.
DR STRING; 5762.D2V1T0; -.
DR EnsemblProtists; EFC49364; EFC49364; NAEGRDRAFT_30302.
DR GeneID; 8855217; -.
DR VEuPathDB; AmoebaDB:NAEGRDRAFT_30302; -.
DR eggNOG; KOG2749; Eukaryota.
DR InParanoid; D2V1T0; -.
DR OMA; VQYVNCH; -.
DR OrthoDB; 56092at2759; -.
DR Proteomes; UP000006671; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0051731; F:polynucleotide 5'-hydroxyl-kinase activity; IEA:InterPro.
DR GO; GO:0031124; P:mRNA 3'-end processing; IEA:InterPro.
DR Gene3D; 2.60.120.1030; Clp1, DNA binding domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.330; Pre-mRNA cleavage complex subunit Clp1, C-terminal domain; 1.
DR InterPro; IPR045116; Clp1/Grc3.
DR InterPro; IPR010655; Clp1_C.
DR InterPro; IPR038238; Clp1_C_sf.
DR InterPro; IPR032324; Clp1_N.
DR InterPro; IPR038239; Clp1_N_sf.
DR InterPro; IPR032319; CLP1_P.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR12755; CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P; 1.
DR PANTHER; PTHR12755:SF6; POLYRIBONUCLEOTIDE 5'-HYDROXYL-KINASE CLP1; 1.
DR Pfam; PF06807; Clp1; 1.
DR Pfam; PF16573; CLP1_N; 1.
DR Pfam; PF16575; CLP1_P; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000006671}.
FT DOMAIN 6..98
FT /note="Clp1 N-terminal beta-sandwich"
FT /evidence="ECO:0000259|Pfam:PF16573"
FT DOMAIN 111..300
FT /note="Polyribonucleotide 5'-hydroxyl-kinase Clp1 P-loop"
FT /evidence="ECO:0000259|Pfam:PF16575"
FT DOMAIN 305..417
FT /note="Pre-mRNA cleavage complex subunit Clp1 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06807"
SQ SEQUENCE 418 AA; 46868 MW; 4FC4B8877FA15A1F CRC64;
MEHRVELKAG EELRFEVGFD ESIKIKLVEG KAEFFGSELA LNRDYNFIGG RNGAIFTYHG
ATIEMESSKG KDNISNYVGS ETPMKEYLEF HDKINMERGP VNNPPRVLVV GPADTGKSSV
AKILVNYAVR VGKKVIFVDL DCGQNDITFP GTISMVAKNA YEPIDIEDEF SLCSPLTYFY
GETTPDKNVD HFKKIVEQTK KMIDRKCSVD QFYEEGGFIV NTGSWVDSSG IQLLLYIVKT
MQINHVIVMD DDRLTNNLKK DLKDTKAVVT RLKKNPGVIN RSKEQRTTAN QLKTKQYFYG
MHKSLSPHSI VVRFEDFTLC RIGGEWQAPL SALPIGAKSS YNPVEVKQVD HSEITKFSIL
AVSLADKLED VLTRNIYGVI HVTKIDHENK TMTILSPSPG KGLPGKFVIA GHVSWLDT
//
