ID D2V4S2_NAEGR Unreviewed; 383 AA.
AC D2V4S2;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Predicted protein {ECO:0000313|EMBL:EFC47983.1};
GN ORFNames=NAEGRDRAFT_63889 {ECO:0000313|EMBL:EFC47983.1};
OS Naegleria gruberi (Amoeba).
OC Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC Vahlkampfiidae; Naegleria.
OX NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN [1] {ECO:0000313|EMBL:EFC47983.1, ECO:0000313|Proteomes:UP000006671}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEG-M {ECO:0000313|EMBL:EFC47983.1,
RC ECO:0000313|Proteomes:UP000006671};
RX PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT "The genome of Naegleria gruberi illuminates early eukaryotic
RT versatility.";
RL Cell 140:631-642(2010).
CC -!- SIMILARITY: Belongs to the serpin family.
CC {ECO:0000256|RuleBase:RU000411}.
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DR EMBL; GG738852; EFC47983.1; -; Genomic_DNA.
DR RefSeq; XP_002680727.1; XM_002680681.1.
DR AlphaFoldDB; D2V4S2; -.
DR STRING; 5762.D2V4S2; -.
DR MEROPS; I04.079; -.
DR EnsemblProtists; EFC47983; EFC47983; NAEGRDRAFT_63889.
DR GeneID; 8860528; -.
DR VEuPathDB; AmoebaDB:NAEGRDRAFT_63889; -.
DR eggNOG; KOG2392; Eukaryota.
DR InParanoid; D2V4S2; -.
DR OrthoDB; 3218836at2759; -.
DR Proteomes; UP000006671; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR CDD; cd00172; serpin; 1.
DR Gene3D; 2.30.39.10; Alpha-1-antitrypsin, domain 1; 1.
DR Gene3D; 3.30.497.10; Antithrombin, subunit I, domain 2; 1.
DR Gene3D; 2.10.310.10; Serpins superfamily; 1.
DR InterPro; IPR023796; Serpin_dom.
DR InterPro; IPR000215; Serpin_fam.
DR InterPro; IPR036186; Serpin_sf.
DR InterPro; IPR042178; Serpin_sf_1.
DR InterPro; IPR042185; Serpin_sf_2.
DR PANTHER; PTHR11461:SF211; ACCESSORY GLAND PROTEIN ACP76A-RELATED; 1.
DR PANTHER; PTHR11461; SERINE PROTEASE INHIBITOR, SERPIN; 1.
DR Pfam; PF00079; Serpin; 1.
DR SMART; SM00093; SERPIN; 1.
DR SUPFAM; SSF56574; Serpins; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000006671}.
FT DOMAIN 17..383
FT /note="Serpin"
FT /evidence="ECO:0000259|SMART:SM00093"
SQ SEQUENCE 383 AA; 42727 MW; 389B426661F2E732 CRC64;
MGQYQSTLIT SHNKFASSLF QSITTKNKQT NIIFSPISIY LTVLMATGGS NGQTLSEFGK
GIFLDQSPST VEVFRLIIEP FASNFFDNLN TSIINVANNV FVERNAILNE NYKEHVQKAF
QVNVEQCDFA GNANGEAVNI NQWVSSHTNQ KINNLIPPNH LNSLTRLVLV NAVHFLGKWK
EVFNISNSYT TTFHGAGGDS TCTIMQKERT KEQYGAEGLY HWVTMSFNDA KYKLTIVAVK
DNSHQTTFDD WFSKKLSQGF ESGFPTRETQ MHSCGFPRFE LEQGMELNEI LQASPFNIQK
AFTTNADFSN LIVNDQIHIN AVIHKAYIKV NENGAEAGAA LSMDCATFSI VKNPEFLVTS
PFAFILTDDS TKSILFAGKV NTL
//
