ID D2V545_NAEGR Unreviewed; 968 AA.
AC D2V545;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Predicted protein {ECO:0000313|EMBL:EFC48046.1};
DE Flags: Fragment;
GN ORFNames=NAEGRDRAFT_31066 {ECO:0000313|EMBL:EFC48046.1};
OS Naegleria gruberi (Amoeba).
OC Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC Vahlkampfiidae; Naegleria.
OX NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN [1] {ECO:0000313|EMBL:EFC48046.1, ECO:0000313|Proteomes:UP000006671}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEG-M {ECO:0000313|EMBL:EFC48046.1,
RC ECO:0000313|Proteomes:UP000006671};
RX PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT "The genome of Naegleria gruberi illuminates early eukaryotic
RT versatility.";
RL Cell 140:631-642(2010).
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DR EMBL; GG738852; EFC48046.1; -; Genomic_DNA.
DR RefSeq; XP_002680790.1; XM_002680744.1.
DR AlphaFoldDB; D2V545; -.
DR STRING; 5762.D2V545; -.
DR EnsemblProtists; EFC48046; EFC48046; NAEGRDRAFT_31066.
DR GeneID; 8861448; -.
DR VEuPathDB; AmoebaDB:NAEGRDRAFT_31066; -.
DR eggNOG; KOG0204; Eukaryota.
DR InParanoid; D2V545; -.
DR OrthoDB; 5475306at2759; -.
DR Proteomes; UP000006671; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0005388; F:P-type calcium transporter activity; IEA:InterPro.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR Gene3D; 1.20.1110.10; Calcium-transporting ATPase, transmembrane domain; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR006068; ATPase_P-typ_cation-transptr_C.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR006408; P-type_ATPase_IIB.
DR InterPro; IPR001757; P_typ_ATPase.
DR NCBIfam; TIGR01517; ATPase-IIB_Ca; 1.
DR PANTHER; PTHR24093:SF369; CALCIUM-TRANSPORTING ATPASE; 1.
DR PANTHER; PTHR24093; CATION TRANSPORTING ATPASE; 1.
DR Pfam; PF13246; Cation_ATPase; 1.
DR Pfam; PF00689; Cation_ATPase_C; 1.
DR Pfam; PF00122; E1-E2_ATPase; 1.
DR PRINTS; PR00120; HATPASE.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF81660; Metal cation-transporting ATPase, ATP-binding domain N; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006671};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 78..98
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 110..129
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 265..287
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 307..330
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 730..753
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 765..783
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 810..831
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 843..860
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 881..904
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 910..933
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 760..932
FT /note="Cation-transporting P-type ATPase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00689"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EFC48046.1"
SQ SEQUENCE 968 AA; 109465 MW; 08155F44582D73E3 CRC64;
EQLQEFNDNH DVYKLQNEYG GAHGLAQALG SNIKEGISNY EVQERGFHFG KHFSLQRVSP
TRYNSWFRLF IITFKDSFMK TFLILAIISI ILGVILPTEQ KERRKGWIEG VSLLIGCLFV
CVANSFIGWQ KKRKWNEIHT LQDAQYRVKV TRDGKITSIL MENLVVGDIL HVEPGDFVTC
SGIVVDSHNL ICDESFFTAN DTNSLKDKNL NPFIDPETFI VEGYGSILVT SVGVKQILLD
ALLNSKDEES SSPLETRLFS IANNIWKIAI GFSLSVFALL MVGWTIYKIG LIQNYQEEWI
VTDLLTVLKM ICLCFSVLFV CTPNGIYKII TTSMAYSSRK TIRDNILLSV NQNMDVSERL
GYTSQVIIGK SALTQKSMEV VKAIIAGENI EIGTGDVQID ETLLQILSSA LSVNSRADIR
NDDNMQIEES IGDSLDCSLL IFLQQIGVDY APIRNYYFEN NKIVKMFTKK NGTMTTIVRN
NGNYILFTKG CYESILENSS GELLKEGVVA SFTDNRKEEL RETMSKHIQE GYTIIAIAYR
EIEDTNILFE NNLTIDDDCY SNLVLISFLI ILNPLTTGIK ESISQLRDAG IFVRLVTGES
VSSAKRLATE CGIMTEDGTC LEGPSFFNLN EDELIKTLPN LQVVARANNA HKYHLISELQ
KQGEFVTILS SSHKDVPSIR KADIGAVCGI KGSHWSKYYA DLFITDDRLS SLVRAIAWGR
ALFYNIQKYL VFHMTINIVV MTLTAVTSIT AYLLSPVQFP PFNPVQLLFV HIIMDIFAAL
SLASDPPHKE TMKQDPIKPK SSIVRKNMKF HIVGQILYQL VVLMILHYSG IYICINNKDG
DKLFVETMVF NTFIFCQIFN EINCRRIDNG MNLLKNIHHS LLFVAIFILN IAFQVFLVQL
SLASLVPLTW YQWLVCVAIG FICVPFGYVL RFLSSRIITS NKLKKGMNKI FKRMVRSVPS
RNHNLNIT
//
