ID   D2V5J4_NAEGR            Unreviewed;       777 AA.
AC   D2V5J4;
DT   02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT   02-MAR-2010, sequence version 1.
DT   27-MAR-2024, entry version 59.
DE   RecName: Full=AP complex subunit beta {ECO:0000256|PIRNR:PIRNR002291};
GN   ORFNames=NAEGRDRAFT_78663 {ECO:0000313|EMBL:EFC47807.1};
OS   Naegleria gruberi (Amoeba).
OC   Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC   Vahlkampfiidae; Naegleria.
OX   NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN   [1] {ECO:0000313|EMBL:EFC47807.1, ECO:0000313|Proteomes:UP000006671}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NEG-M {ECO:0000313|EMBL:EFC47807.1,
RC   ECO:0000313|Proteomes:UP000006671};
RX   PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA   Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA   Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA   Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA   Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT   "The genome of Naegleria gruberi illuminates early eukaryotic
RT   versatility.";
RL   Cell 140:631-642(2010).
CC   -!- SIMILARITY: Belongs to the adaptor complexes large subunit family.
CC       {ECO:0000256|ARBA:ARBA00006613, ECO:0000256|PIRNR:PIRNR002291}.
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DR   EMBL; GG738853; EFC47807.1; -; Genomic_DNA.
DR   RefSeq; XP_002680551.1; XM_002680505.1.
DR   AlphaFoldDB; D2V5J4; -.
DR   STRING; 5762.D2V5J4; -.
DR   EnsemblProtists; EFC47807; EFC47807; NAEGRDRAFT_78663.
DR   GeneID; 8849471; -.
DR   VEuPathDB; AmoebaDB:NAEGRDRAFT_78663; -.
DR   eggNOG; KOG1060; Eukaryota.
DR   InParanoid; D2V5J4; -.
DR   OrthoDB; 7857at2759; -.
DR   Proteomes; UP000006671; Unassembled WGS sequence.
DR   GO; GO:0030117; C:membrane coat; IEA:InterPro.
DR   GO; GO:0030276; F:clathrin binding; IEA:InterPro.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR026739; AP_beta.
DR   InterPro; IPR016342; AP_complex_bsu_1_2_4.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR002553; Clathrin/coatomer_adapt-like_N.
DR   PANTHER; PTHR11134; ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER; 1.
DR   PANTHER; PTHR11134:SF1; AP-3 COMPLEX SUBUNIT BETA; 1.
DR   Pfam; PF01602; Adaptin_N; 1.
DR   PIRSF; PIRSF002291; AP_complex_beta; 2.
DR   SUPFAM; SSF48371; ARM repeat; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|PIRNR:PIRNR002291};
KW   Protein transport {ECO:0000256|PIRNR:PIRNR002291};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006671};
KW   Transport {ECO:0000256|PIRNR:PIRNR002291}.
FT   DOMAIN          22..583
FT                   /note="Clathrin/coatomer adaptor adaptin-like N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01602"
FT   REGION          686..777
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        686..761
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   777 AA;  88696 MW;  28DBBBCA4BD5D180 CRC64;
     MSYTGVLGGD SKYFKESNTA KFDEITKQLD SNNFRDKLVG MKKVIAMASS GKEVEPLFPY
     VVKNCITKNV ELKKLVYMYL VHFAEQKQEE ALLSINNFQK DLDDKNQFLR ALALRVMSSL
     NVQDITTVIL VGIKKCLHDM SPYVRKAAAL GIIKVFRQSP EELAVECAEL IGELLKDNNT
     MVLGAAVHAF NEVCPTNYEL IHPVFRKLCR YLVDCDEWGQ CSIMQMLLRY GRTHFQSPFK
     GETYKKRAFY DDEDDEEGDH DGNKEIFDDG YEPGAEMELD QDHRLLLRST APLLRTRNSA
     VVLMVVNLHF YLSPRQEFSL KCVTPLLRIL RSYRENAYIV LMSVSTIARE RPEVFGNHLK
     DFFIYASDPA YVRNLKLEIL SLLATDETVH SILKEFRTYV KFPEQDFVNN TIKAMGRVAS
     KIPEVVESCI GTLMNLITKG SEHIVAESII AIHQLLQQNP EDNKKIILQM AILLDDIKVP
     IARASIAYMI GEYIEYLPSG GVGIGVAADA LRILAKDFVK EDDLVKLQAL NLSTKLYLSL
     ESTGDKKSEQ INMLIQYVLN LARYDQSYDV RDRARFMRNI LFNPKGTTST LHEKSDEIFG
     SSGKKNSVSL NSKFVEDRAR FLLGSLSHIL NHSTSGYTPL PDFPVETLNY EERNVVAATD
     GQADVGAIGE TSSELFTGDI DDFYGEEEEE ESEEYESEEE EEEGDDDNID NFYDSEEEEE
     EEEEEEEEEE GEELEGEEEE EEEEEEEEEE EEEEEEEEEE EFLPPPKKAS TSNLLKF
//