ID D2V6M4_NAEGR Unreviewed; 149 AA.
AC D2V6M4;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Predicted protein {ECO:0000313|EMBL:EFC47604.1};
DE Flags: Fragment;
GN ORFNames=NAEGRDRAFT_4224 {ECO:0000313|EMBL:EFC47604.1};
OS Naegleria gruberi (Amoeba).
OC Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC Vahlkampfiidae; Naegleria.
OX NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN [1] {ECO:0000313|EMBL:EFC47604.1, ECO:0000313|Proteomes:UP000006671}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEG-M {ECO:0000313|EMBL:EFC47604.1,
RC ECO:0000313|Proteomes:UP000006671};
RX PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT "The genome of Naegleria gruberi illuminates early eukaryotic
RT versatility.";
RL Cell 140:631-642(2010).
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class dual specificity subfamily.
CC {ECO:0000256|ARBA:ARBA00008601}.
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DR EMBL; GG738854; EFC47604.1; -; Genomic_DNA.
DR RefSeq; XP_002680348.1; XM_002680302.1.
DR AlphaFoldDB; D2V6M4; -.
DR STRING; 5762.D2V6M4; -.
DR EnsemblProtists; EFC47604; EFC47604; NAEGRDRAFT_4224.
DR GeneID; 8849098; -.
DR VEuPathDB; AmoebaDB:NAEGRDRAFT_4224; -.
DR eggNOG; KOG1716; Eukaryota.
DR InParanoid; D2V6M4; -.
DR OMA; CAYLMWK; -.
DR OrthoDB; 21247at2759; -.
DR Proteomes; UP000006671; Unassembled WGS sequence.
DR GO; GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IEA:InterPro.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd14498; DSP; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR000340; Dual-sp_phosphatase_cat-dom.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR InterPro; IPR020422; TYR_PHOSPHATASE_DUAL_dom.
DR PANTHER; PTHR10159; DUAL SPECIFICITY PROTEIN PHOSPHATASE; 1.
DR PANTHER; PTHR10159:SF519; DUAL SPECIFICITY PROTEIN PHOSPHATASE MPK3; 1.
DR Pfam; PF00782; DSPc; 1.
DR PRINTS; PR01908; ADSPHPHTASE.
DR SMART; SM00195; DSPc; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50054; TYR_PHOSPHATASE_DUAL; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000006671}.
FT DOMAIN 1..146
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50054"
FT DOMAIN 65..125
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EFC47604.1"
FT NON_TER 149
FT /evidence="ECO:0000313|EMBL:EFC47604.1"
SQ SEQUENCE 149 AA; 16872 MW; 4157CB628B587AB1 CRC64;
ASEIIPNFLY LGDFQNGSEM SQLQALGITH IIDATNEHYS EETAKELSIN YLPIDIWDIE
KADISQYFES TNEFIQSAKD QNGKLLCHCR AGWSRSPSIV LAYLISSRFS ASLKEALIWT
VSQRPFVCPN NGFRDQLRCY ETKILGAQS
//
