ID   D2V870_NAEGR            Unreviewed;      1118 AA.
AC   D2V870;
DT   02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT   02-MAR-2010, sequence version 1.
DT   27-MAR-2024, entry version 49.
DE   SubName: Full=FH2 domain-containing protein {ECO:0000313|EMBL:EFC47125.1};
GN   ORFNames=NAEGRDRAFT_78968 {ECO:0000313|EMBL:EFC47125.1};
OS   Naegleria gruberi (Amoeba).
OC   Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC   Vahlkampfiidae; Naegleria.
OX   NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN   [1] {ECO:0000313|EMBL:EFC47125.1, ECO:0000313|Proteomes:UP000006671}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NEG-M {ECO:0000313|EMBL:EFC47125.1,
RC   ECO:0000313|Proteomes:UP000006671};
RX   PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA   Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA   Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA   Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA   Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT   "The genome of Naegleria gruberi illuminates early eukaryotic
RT   versatility.";
RL   Cell 140:631-642(2010).
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DR   EMBL; GG738856; EFC47125.1; -; Genomic_DNA.
DR   RefSeq; XP_002679869.1; XM_002679823.1.
DR   AlphaFoldDB; D2V870; -.
DR   STRING; 5762.D2V870; -.
DR   EnsemblProtists; EFC47125; EFC47125; NAEGRDRAFT_78968.
DR   GeneID; 8861302; -.
DR   VEuPathDB; AmoebaDB:NAEGRDRAFT_78968; -.
DR   eggNOG; KOG1923; Eukaryota.
DR   InParanoid; D2V870; -.
DR   OrthoDB; 53873at2759; -.
DR   Proteomes; UP000006671; Unassembled WGS sequence.
DR   Gene3D; 2.60.40.1110; -; 1.
DR   Gene3D; 1.20.58.2220; Formin, FH2 domain; 1.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR015425; FH2_Formin.
DR   InterPro; IPR042201; FH2_Formin_sf.
DR   InterPro; IPR014020; Tensin_C2-dom.
DR   PANTHER; PTHR45691; PROTEIN DIAPHANOUS; 1.
DR   PANTHER; PTHR45691:SF6; PROTEIN DIAPHANOUS; 1.
DR   Pfam; PF02181; FH2; 1.
DR   Pfam; PF10409; PTEN_C2; 1.
DR   SMART; SM00498; FH2; 1.
DR   SMART; SM01326; PTEN_C2; 1.
DR   SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR   SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR   PROSITE; PS51182; C2_TENSIN; 1.
DR   PROSITE; PS51444; FH2; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000006671}.
FT   DOMAIN          364..535
FT                   /note="C2 tensin-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51182"
FT   DOMAIN          687..1108
FT                   /note="FH2"
FT                   /evidence="ECO:0000259|PROSITE:PS51444"
FT   REGION          184..213
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          591..647
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          737..771
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        598..616
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        617..647
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        752..771
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1118 AA;  126239 MW;  BAA2A9AAEA545668 CRC64;
     MFKALRNYWN YNDIIDININ ERLKYIHNDN GTDEMNNRIS TMLTDKYSDK VFVFNFTSKP
     FPAVTTRPCF EIGSTPVISE HFEQLPVLLS LSSMIDNFLL NYSTSKDYCI VIVASTKTTC
     YALLLAAVFV SYTDSKMYMD MYGIEQSSLK SHHPERTVTT VVLDGAGGSS SNLASVSVNS
     LENLDTSDQQ QPQSNSTEVS PNVEPNQSQD NEVNITVTTA DEEDGKVLLN NNDLDAVSTT
     SNQTTTTTTT NYSQRILNTM MILNQARDIV YTRLEKKLNP KSMTLLKSLE PSVYRYANLF
     LISLQRPLTL MVHDVPMLTF SPSVNPTFKG FFKPSVFRLQ CISMNSSRLC VKHSNHNMAT
     SMVESTSRDR RMSLQPSRTT PKRDEWLAIK GDDEDTVPDS LNSFQYRKLY FVVRKQTDIL
     FSTFTTASVN NAPRVERRKT FMSSPRGEER PSTRIETWFH YTLPFNESKP LMGDFILLAF
     TMADDGNIIS LFRFTFNTLF LTSTVVVVDK SELDWAHNSP SFSGNFKLEL NFSEIDCASE
     EDAADLSTSY WTELVCSLEK CPHFLSRTTE IEHARYLIST KPYADMNIVE EEKEPEPSTT
     TQPTSVNNSP VPNSNIPLPS SNIPLPPGGS NIPPPPGSNI PPPPPFGNIP PPPGMGIPLP
     PGGIPFPPGV PPPPGAISFG TKKKYIQHTE EEEVSKTKQL HWKPIKKVDS EYSVWSKIEV
     DPNMIDLEKI EMLFAKQTKA EEEPEPATGG ATPRQGFTSP RGGTKASPRT LQKSLATEGI
     IDNKTARNIE IIINSQFKSI SNEIVVEAIN NLDITKLTNQ QIENLEQFTS SGDTLTMKTK
     LKGLDREELP KSDIFFLDIL AIEDVASKLR LMRYMSSFPI LLKEVSEKIE KKRKAIECIV
     NCKSFAKLLS YVLAIGSFMN RGKKRLEGEG FDLRILTKLK DTRSTVDKST TLISYLVKIC
     DEETRNFDEE LYEAGVCNNG VIITVPGLVL NFSELESMYK FICKSKQDIP RGAYTDSYKK
     MLEEFYELCQ KDFPSTKESF EKLQKEFTAC YEFYHFVPVE STDKQLAEDE FFALISEFVL
     QFKKAKEAVF KSQVAARSMK RSQSMKLDLN RVRPGIEK
//