ID   D2VAZ6_NAEGR            Unreviewed;      1200 AA.
AC   D2VAZ6;
DT   02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT   02-MAR-2010, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   SubName: Full=Predicted protein {ECO:0000313|EMBL:EFC46169.1};
GN   ORFNames=NAEGRDRAFT_66034 {ECO:0000313|EMBL:EFC46169.1};
OS   Naegleria gruberi (Amoeba).
OC   Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC   Vahlkampfiidae; Naegleria.
OX   NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN   [1] {ECO:0000313|EMBL:EFC46169.1, ECO:0000313|Proteomes:UP000006671}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NEG-M {ECO:0000313|EMBL:EFC46169.1,
RC   ECO:0000313|Proteomes:UP000006671};
RX   PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA   Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA   Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA   Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA   Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT   "The genome of Naegleria gruberi illuminates early eukaryotic
RT   versatility.";
RL   Cell 140:631-642(2010).
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DR   EMBL; GG738860; EFC46169.1; -; Genomic_DNA.
DR   RefSeq; XP_002678913.1; XM_002678867.1.
DR   AlphaFoldDB; D2VAZ6; -.
DR   STRING; 5762.D2VAZ6; -.
DR   EnsemblProtists; EFC46169; EFC46169; NAEGRDRAFT_66034.
DR   GeneID; 8848493; -.
DR   VEuPathDB; AmoebaDB:NAEGRDRAFT_66034; -.
DR   InParanoid; D2VAZ6; -.
DR   OrthoDB; 5478281at2759; -.
DR   Proteomes; UP000006671; Unassembled WGS sequence.
DR   Gene3D; 3.40.50.11500; -; 1.
DR   InterPro; IPR001194; cDENN_dom.
DR   InterPro; IPR043153; DENN_C.
DR   InterPro; IPR037516; Tripartite_DENN.
DR   PANTHER; PTHR12296:SF21; DENN DOMAIN-CONTAINING PROTEIN 3; 1.
DR   PANTHER; PTHR12296; DENN DOMAIN-CONTAINING PROTEIN 4; 1.
DR   Pfam; PF02141; DENN; 1.
DR   SMART; SM00799; DENN; 1.
DR   PROSITE; PS50211; DENN; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000006671};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           19..1200
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003037394"
FT   DOMAIN          128..607
FT                   /note="UDENN"
FT                   /evidence="ECO:0000259|PROSITE:PS50211"
FT   REGION          69..100
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          801..872
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        801..817
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        844..872
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1200 AA;  138115 MW;  8EE85E0D74C3EE89 CRC64;
     MSTKAAVLLS TVAVFVLPEQ LQQQQQQQQN GDLFGSVLNG SSSRMKVGSP QPVSNQLFMN
     SFSSQPSTPV SSPIVSSASS SFSRNNSSKP SSPSLLGKSF SSPALKKTSL DFQRPESTSV
     MNYQQHLKSN QKESFNPKKF ASPQADLVYT FPSVLSQDKM VNLKSMPLFC FYSQHENKES
     YVARDSKIVV PPTTSQSSLM NNVNRDEIVV QLFPFVTTDF FKNECYCFCL RIDNQLEKVA
     IVFESSLPIY DLLKEMVLEM FNCGIFDIFL NKGFREEQMR NQSTTLNNGS TFPNDDKLPL
     KKAAFQRTID MLLNKVPIPA PSRISSVSFR PLKKKYSLRF PDVEELPFCN KIILVSDSVA
     LMTYCAEALR ILLYPFQFPL MFAFIPHLPV QLLETILSPV PYIVGVHGSL KRELFSVIEQ
     QNRMFEQTAK ISNGETEHDK SLIVLDIDNS MFLYGKSPER EFKFPEPYRF QLIEKLKIIQ
     KPSFKTMDFL QGAAYTQNEQ NSSTDTKIRE AFTSLYCKLL SPLNIHILTR KWVKKNKRNE
     NDYIDNIKKY VTEEAEDIDI RLKEFLRNLF NNQIFSELLN HGMEEQYFYQ ELCFSIFVNR
     EMEQLVNYKN LILPSDYSGT NTLLDFDVNL FENSIVPQSN PNDSLLLWIE NKIDNTHSLG
     NNEILLNYVK SRLVLMRAFI YERKEQYIKC LEDTLECITT CMDERLIKRE WFESIILRIP
     KKNLSQYIAK MKTQYIQTPE DNYRLSFLEK IIMEMHQSHV TDVKSIFEQS KTIDVSIKSG
     RRTSFHEYLD EAGETDAFSF EENNDTPLAS SLPNESIILP DDTEDVSPSS PPENDDIEGL
     QTPLTKRRSL SFTDVTTDSP LQSQVPSSRT ANINTKNGSI LLSLPYINFS RIEQQLIPKN
     IESINKASSL RRRSASIFVK KKKDEEVACV NISKEMFSMI TFESGMFFSK QDGDRVYQQL
     VEIQQDKLNI PDTLLNPETL KKFLSWFRTI NQFNQYSTFR LRKIESFSEV PSSLLADQES
     HKHVVLTQST FCKASFFFSK ISSLDDSVRS DSLIQVDENT KTGRICFCND GSIYFGISRL
     ELVLSDMSQI LKIDHYPPQN MLKQQPDLLH LTIEGIVKIV IKMDQDNCRV VEFKFPTTIQ
     SLKWYSHFLS LMNFSTSMTM NLIMSKKQNV QSVPTNPTTV SIFRNITIDH VLYMMNSAYQ
//