ID D2VB33_NAEGR Unreviewed; 395 AA.
AC D2VB33;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Predicted protein {ECO:0000313|EMBL:EFC46054.1};
GN ORFNames=NAEGRDRAFT_48104 {ECO:0000313|EMBL:EFC46054.1};
OS Naegleria gruberi (Amoeba).
OC Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC Vahlkampfiidae; Naegleria.
OX NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN [1] {ECO:0000313|EMBL:EFC46054.1, ECO:0000313|Proteomes:UP000006671}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEG-M {ECO:0000313|EMBL:EFC46054.1,
RC ECO:0000313|Proteomes:UP000006671};
RX PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT "The genome of Naegleria gruberi illuminates early eukaryotic
RT versatility.";
RL Cell 140:631-642(2010).
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DR EMBL; GG738860; EFC46054.1; -; Genomic_DNA.
DR RefSeq; XP_002678798.1; XM_002678752.1.
DR AlphaFoldDB; D2VB33; -.
DR STRING; 5762.D2VB33; -.
DR EnsemblProtists; EFC46054; EFC46054; NAEGRDRAFT_48104.
DR GeneID; 8850536; -.
DR VEuPathDB; AmoebaDB:NAEGRDRAFT_48104; -.
DR eggNOG; KOG1198; Eukaryota.
DR InParanoid; D2VB33; -.
DR OMA; EDYCEEP; -.
DR OrthoDB; 2688376at2759; -.
DR Proteomes; UP000006671; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR CDD; cd08267; MDR1; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR PANTHER; PTHR11695; ALCOHOL DEHYDROGENASE RELATED; 1.
DR PANTHER; PTHR11695:SF294; RETICULON-4-INTERACTING PROTEIN 1, MITOCHONDRIAL; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF13602; ADH_zinc_N_2; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000006671}.
FT DOMAIN 12..392
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
SQ SEQUENCE 395 AA; 43380 MW; B93CBD83E46E90C0 CRC64;
MKAMIIEDYC EEPDFKLVTD FEKPKVSSSK QVLVNLKTAS VNPVDYKLRK GAMKMAASMK
FPAILGKDGS GVVEQVGAKV DRFKVGDRVT GFLPNNKTGS YAEYAVFEDD ELTLYPDQLT
HQQAAAFPLA GCTVLEMYRR HPLIGEVLDR EGESAYKTGK ISDALTGTKK DLKILIIGAS
GGTGSIAVMV AKQFLSRYFN TKIYAVCSER NSQFVTSLGA DVVIDYNKTS AKAGAHTTHA
SGGLADSMKS ICQLISETHG DKYVDIVIDT VGGYYYYEDV CQHLDCKSAE KGVTFSTIST
PNPNEYTLTF SSLVKIGCYI SSNKLKSMSS CYPSYHMVFL GKNAKDMNLL LNHIVVSNDA
YKLLPLIPFS LENTKDAHLQ MQSQRTVGKI IIDIE
//
