ID   D2VG20_NAEGR            Unreviewed;      1928 AA.
AC   D2VG20;
DT   02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT   02-MAR-2010, sequence version 1.
DT   27-MAR-2024, entry version 42.
DE   RecName: Full=Right handed beta helix domain-containing protein {ECO:0000259|Pfam:PF13229};
GN   ORFNames=NAEGRDRAFT_79837 {ECO:0000313|EMBL:EFC44188.1};
OS   Naegleria gruberi (Amoeba).
OC   Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC   Vahlkampfiidae; Naegleria.
OX   NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN   [1] {ECO:0000313|EMBL:EFC44188.1, ECO:0000313|Proteomes:UP000006671}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NEG-M {ECO:0000313|EMBL:EFC44188.1,
RC   ECO:0000313|Proteomes:UP000006671};
RX   PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA   Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA   Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA   Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA   Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT   "The genome of Naegleria gruberi illuminates early eukaryotic
RT   versatility.";
RL   Cell 140:631-642(2010).
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DR   EMBL; GG738869; EFC44188.1; -; Genomic_DNA.
DR   RefSeq; XP_002676932.1; XM_002676886.1.
DR   EnsemblProtists; EFC44188; EFC44188; NAEGRDRAFT_79837.
DR   GeneID; 8848089; -.
DR   VEuPathDB; AmoebaDB:NAEGRDRAFT_79837; -.
DR   InParanoid; D2VG20; -.
DR   OrthoDB; 5470986at2759; -.
DR   Proteomes; UP000006671; Unassembled WGS sequence.
DR   Gene3D; 2.120.10.80; Kelch-type beta propeller; 1.
DR   Gene3D; 2.160.20.10; Single-stranded right-handed beta-helix, Pectin lyase-like; 3.
DR   InterPro; IPR039448; Beta_helix.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006626; PbH1.
DR   InterPro; IPR012334; Pectin_lyas_fold.
DR   InterPro; IPR011050; Pectin_lyase_fold/virulence.
DR   PANTHER; PTHR23244; KELCH REPEAT DOMAIN; 1.
DR   PANTHER; PTHR23244:SF471; KELCH REPEAT-CONTAINING PROTEIN 1-RELATED; 1.
DR   Pfam; PF13229; Beta_helix; 3.
DR   SMART; SM00710; PbH1; 16.
DR   SUPFAM; SSF81383; F-box domain; 1.
DR   SUPFAM; SSF117281; Kelch motif; 1.
DR   SUPFAM; SSF51126; Pectin lyase-like; 3.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000006671}.
FT   DOMAIN          153..315
FT                   /note="Right handed beta helix"
FT                   /evidence="ECO:0000259|Pfam:PF13229"
FT   DOMAIN          617..751
FT                   /note="Right handed beta helix"
FT                   /evidence="ECO:0000259|Pfam:PF13229"
FT   DOMAIN          1033..1212
FT                   /note="Right handed beta helix"
FT                   /evidence="ECO:0000259|Pfam:PF13229"
SQ   SEQUENCE   1928 AA;  213888 MW;  6C6936FEF633CB2B CRC64;
     MIVLGFGVQE GSCTVYEVRN STSLWDIVHG NKLVPGDEVV LREGNYTCYY QSTWYRNIVL
     KGLTNAPITI RAASGEKVLV EGDLNASQNL LNFNVENFIL KGIEFRYGDR GLRFFGASNV
     LLEDLHIHDT SDVGMAMNDR DVTYSNKLDE NRHVQIHHTH GTGECFYLGC NDDACRLINS
     LIEYNYCHHT CCVQGDGIEV KRGSYNNVIR HNVIHDTHYP GIIVYGANNG IPNIIDSNII
     WNAGDNGIQI AANTIARNNI VLNSKMNGIS IQPNQGNPTA VILEHNTVIG ALSGSCLSTY
     STYIGSEFVI ANNAFYCENA SAISETNANS KTVYLSNVVK GKVTSQYASN IIYGTGLRDF
     TSTASLPFNT YPSLGSSLLG VSTYMANTST PLDFDGRDRS AASRIDAGAY QRVAQNSPTW
     IPVAGFKDGW SSPAQSTSPK RVKPVPSDNA HYNRTTFIIT PQNGSSLFDL MSTLQPGDTL
     LVRAGTYPVK FANAWFTKIV LSGSPSNPIT VSAWPGERVV LYGDPYGSQN IINLEVMYFV
     FRGFEMVYGS RGIRLHESSH SIFEDLNVHH TWANAISAND KGVHYQNITF RNNRVAHTHG
     TGECFYLGCQ DAACIFSDSL IEGNLCEYTC CEQGDGIELK HGSYNNIVRN NVVHDTPYPG
     ITTYTTGGNA PNIIEGNFIF NTGDNGIQCT SGQIIRNNII VNASINGIDI HDDGAVSDLT
     ITHNTVINAK IACFSAGGLQ TASNVIIANN ALFCDNSQYG YYERYLSDKK TSTFYSARNY
     YSGKTNGVGI DLVKVNNSSH DILLGIDLLN AYPTSISNLI GAGSLKYSTP LDFNGNSRSS
     TPDVGAYQYS TPSNPGWVAK GWFKNGYNSV SVSGNWEYPK NVLIPQDDDS YIGMVYHITE
     ANYSSSNCKY ENIWKTMALL KPGDTMIFHS GTLLTQVCGH GSFYRRLTVI GSPNRPVVIK
     VADGESVTIQ GDIGQSQNIM DVAFYNVLFK GFNMKYGSRG LRVYEAQNTT FEGLEISETA
     DVAFAGNDLR GDYNNVTIRR VKVHHTHGTG ECFYLGCNFG ECIWRNSIIE YNHCSHTCCE
     QGDGIELKAG SYGNIIRHNV IHDTIYPGIT LYTPMEGKPP NVVYGNIVWN TQDNGIQVTG
     NTILMNNIVM NAKYYGISIQ ENQQRVNGLG NIENVAILHN TVVGVSSKTS GACFATSGTN
     SGKGNIVIAG NAFYCSDAKA TREVNVHPNT KYGINVVSGT STMSGTLIGD LVSDFLDVSS
     IPYNLYPRKG GKLYGSSNLT IYDLVSKDFN GLVRSSQRMD VGALQYIEGK DNNPGWIPKD
     EFKPFTDLSP LAMLDFEDTS CCSLFLIFGG RSSEIREGTC MVNDEKQLYL IEMVDNEFST
     CLSYVYDENV LNEKQIPQAR YGHSSVFDKD RKLMYVFGGM AGGKCHNDLA IFDVVTSLWT
     IVNFANVGCL ILPQERYGHN CAIYKNWMFV CGGRDSSGNI LGGIQAMDLD RCLWMNIQVE
     SLSGRSFFTM DVIERRDDKI EMIIAGGIRK DLNEKPLQRL TITVGNERSI HCSVNPIENQ
     ELTWDKYGHC SVFKNQTLLL VGGQNQDHSL DCNSLEFSIE SETFSSFSYF LQPSTHCSLS
     FLNISQDLDV NQNDGFYFAS LLYDSTLNCY VVGGNSIATY RTTPSIDVSE NVISDTWVKI
     VSFLNYDDLK KLCLVSKRFY TIFTADKLIQ DKISSINDNN KLSNKVWPFK RRSYYEREIN
     FTPPNITCPI RTFKISVVGE PFMVKAFISK ITGKDVNKIT EEEPIHMVQF YFHHNIYHFL
     MDTRTNDIPE DQQQSFSLKL VCIRLGRANQ SIANSHDVTC PTIVLGLEEE LYKFSIFKKS
     YNSQYFQHVL PFATSKDLTL IFKQITSIGA FEKISTETGF GMYQLLEFFL DCIKNDPTQS
     STSGCELN
//