ID   D2VGI7_NAEGR            Unreviewed;       257 AA.
AC   D2VGI7;
DT   02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT   02-MAR-2010, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   RecName: Full=GtrA/DPMS transmembrane domain-containing protein {ECO:0000259|Pfam:PF04138};
GN   ORFNames=NAEGRDRAFT_79891 {ECO:0000313|EMBL:EFC44073.1};
OS   Naegleria gruberi (Amoeba).
OC   Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC   Vahlkampfiidae; Naegleria.
OX   NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN   [1] {ECO:0000313|EMBL:EFC44073.1, ECO:0000313|Proteomes:UP000006671}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NEG-M {ECO:0000313|EMBL:EFC44073.1,
RC   ECO:0000313|Proteomes:UP000006671};
RX   PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA   Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA   Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA   Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA   Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT   "The genome of Naegleria gruberi illuminates early eukaryotic
RT   versatility.";
RL   Cell 140:631-642(2010).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; GG738870; EFC44073.1; -; Genomic_DNA.
DR   RefSeq; XP_002676817.1; XM_002676771.1.
DR   AlphaFoldDB; D2VGI7; -.
DR   EnsemblProtists; EFC44073; EFC44073; NAEGRDRAFT_79891.
DR   GeneID; 8847993; -.
DR   VEuPathDB; AmoebaDB:NAEGRDRAFT_79891; -.
DR   eggNOG; ENOG502SDKF; Eukaryota.
DR   InParanoid; D2VGI7; -.
DR   OrthoDB; 5487868at2759; -.
DR   Proteomes; UP000006671; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:InterPro.
DR   InterPro; IPR007267; GtrA_DPMS_TM.
DR   Pfam; PF04138; GtrA; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006671};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        127..148
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        201..222
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        228..250
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          132..250
FT                   /note="GtrA/DPMS transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF04138"
SQ   SEQUENCE   257 AA;  28836 MW;  CB9ACC2EF1739147 CRC64;
     MLQPPTLRTN VSSLLQTNSN ASGGGINNVI GSSSSSVVGS LPPSKDSSVV TSPQDLEDLI
     HHHRSESPSS PIHHQSDALL SSSIVEIKDT SQSLQEVTTS SPDDISALVD SFFYNNGPSR
     MTEGRKVFLF QVSTIIGTFI FFLFYHFLYQ FITSEDESTK SSLCWLLSYS LSIWCQYELH
     CRIVFGKRSN SEYWRSLIRT YFVYGISMVF STILNYMLVG YFKVGHTYAW ILSLILVGIL
     NYFTVSKFAF ADSEETL
//