ID   D2VIN1_NAEGR            Unreviewed;      1375 AA.
AC   D2VIN1;
DT   02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT   02-MAR-2010, sequence version 1.
DT   27-MAR-2024, entry version 65.
DE   SubName: Full=Predicted protein {ECO:0000313|EMBL:EFC43302.1};
GN   ORFNames=NAEGRDRAFT_68736 {ECO:0000313|EMBL:EFC43302.1};
OS   Naegleria gruberi (Amoeba).
OC   Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC   Vahlkampfiidae; Naegleria.
OX   NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN   [1] {ECO:0000313|EMBL:EFC43302.1, ECO:0000313|Proteomes:UP000006671}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NEG-M {ECO:0000313|EMBL:EFC43302.1,
RC   ECO:0000313|Proteomes:UP000006671};
RX   PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA   Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA   Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA   Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA   Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT   "The genome of Naegleria gruberi illuminates early eukaryotic
RT   versatility.";
RL   Cell 140:631-642(2010).
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC       family. {ECO:0000256|RuleBase:RU000405}.
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DR   EMBL; GG738874; EFC43302.1; -; Genomic_DNA.
DR   RefSeq; XP_002676046.1; XM_002676000.1.
DR   EnsemblProtists; EFC43302; EFC43302; NAEGRDRAFT_68736.
DR   GeneID; 8861977; -.
DR   VEuPathDB; AmoebaDB:NAEGRDRAFT_68736; -.
DR   eggNOG; KOG1023; Eukaryota.
DR   InParanoid; D2VIN1; -.
DR   OrthoDB; 5515664at2759; -.
DR   Proteomes; UP000006671; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016849; F:phosphorus-oxygen lyase activity; IEA:InterPro.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   CDD; cd00130; PAS; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR018297; A/G_cyclase_CS.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   NCBIfam; TIGR00229; sensory_box; 1.
DR   PANTHER; PTHR11920:SF335; GUANYLATE CYCLASE 32E; 1.
DR   PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   Pfam; PF13426; PAS_9; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SMART; SM00091; PAS; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR   PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR   PROSITE; PS50112; PAS; 1.
PE   3: Inferred from homology;
KW   Lyase {ECO:0000256|RuleBase:RU000405};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006671};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        400..426
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        612..635
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        689..710
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        902..925
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          979..1050
FT                   /note="PAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50112"
FT   DOMAIN          1144..1277
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
FT   REGION          308..344
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1375 AA;  156997 MW;  28D995DC64407624 CRC64;
     MLADRSQYYE QSNDDLDMQD NQESQIIVYE KIIEREAPML YHKIDSEKRM KFLVYYLNFC
     MHRNVDELMN SSHPSAHKKV SRIESIGMTD THVALCFIKG LFGGSTSIVT NVGLMLTCSS
     LVAYYWPSSA ESVNTTLFAN SLLRKALKKQ PSFIQRFLIG IKIKEIEVNA DEKTRLMFEA
     KHLVSKLERR QQELKALHRN FWKELTHEVV NYEKIESIIL RASELSSKCE THYENLRLTY
     RHDKSLLRSH AQFLETCRFD PDIAHEMYNE ASLMEEEDSA NHAMKSKSNL MATVNIAERR
     KMWRDQAKNR PNNRGMANGN VKVVPVNGNK DMVRGDSTSS IEGKEGQEEY GHHFEMIDPR
     TSLSYSDQLP FDGVENFGNV RKETIFRTSL SVPHRHTFQL GGFIAFFILS VCLLISSSIL
     SGLISYEVTD DLQIVKTGCI PTSSIVQMIT KLRSLKFANS LYSQKSWPTE MTSLGFKNLT
     DFNTKMWTDF KQYYSYFIAL RDMSMKDRVL TPTMYDEFHE RYYPMLTPEI SSGSEIILYN
     STKAVNISIA DITNLVIKYS EDLIRTRDSD HTFTNYGFMF FYDNHDYITK AFSQFCSVLI
     DESKHEASQV DIAYMAFLIV ALVVYLLYGT GYIIYTHISL KFVKSQIKLI EHEISKNIAG
     RLFHDLEKKV SDDVTVRLPK SKLLRPKNII IMLSISLMIL MAVCAGLLYF GNRYNAEKIA
     SSFISFRHAT NSMFYVQRIA FAVTEQFTNK VLGGSLQSSE ELYLMNQDLE ENVQSLRENW
     NLCLYGDSKE VYTSIMNRGI LGLFSEVDNL IIGESNCTFS EFRYSYNVSS KCFLSLNSLL
     TDYMSLSTQF NSVLKVKNIN SSDMDIVDQY AQATFLSNMI TMDVVEISSV ISENYSNPAF
     EILITFSIVG SVSILLFSYL IHLYLTKYWN SIQEMRLYFN YISVETLDSN EALRNYCIHH
     LVNDTFLLKR RNMNNTSLQD SKVRSLLNAS VDGAVMCSGQ TCDIDIFNPA AQRMFGYNQT
     ETVGRPLFDL FDSLSQQSIR KMVSDMLQGA SEAQSKGDAL DAECVRKNQT TFPARANIFL
     TKHDNKPIIT IFIKDITSEK KHLALIAEEK KHSEELLLNI LPDAVASKLK SGETFIAEKF
     ADITCFFSDM VNFTRISSDM NPSELVLMLN FIVNGFDELI TKYNLEKIKT IGDAYFAVGG
     LHGLNAQSDH PERTLKFAID TYQVVSNYNS KSGKPMREQI NIRIGMHTGS VVAGVIGKLK
     FAYDLWGDTI NMASRMESNS VNGRIQISRT TYERVYDLGF SFEERTINVK GKGETLAYLL
     DSKHHTSAIV NHEVIEDSEE IESVVLPPRD TLEVIPLRES ASNHTDLVDL APSTP
//