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Database: UniProt
Entry: D2VKL2_NAEGR
LinkDB: D2VKL2_NAEGR
Original site: D2VKL2_NAEGR 
ID   D2VKL2_NAEGR            Unreviewed;      2827 AA.
AC   D2VKL2;
DT   02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT   02-MAR-2010, sequence version 1.
DT   07-NOV-2018, entry version 39.
DE   SubName: Full=Predicted protein {ECO:0000313|EMBL:EFC42710.1};
GN   ORFNames=NAEGRDRAFT_80324 {ECO:0000313|EMBL:EFC42710.1};
OS   Naegleria gruberi (Amoeba).
OC   Eukaryota; Heterolobosea; Schizopyrenida; Vahlkampfiidae; Naegleria.
OX   NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN   [1] {ECO:0000313|EMBL:EFC42710.1, ECO:0000313|Proteomes:UP000006671}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NEG-M {ECO:0000313|EMBL:EFC42710.1,
RC   ECO:0000313|Proteomes:UP000006671};
RX   PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA   Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B.,
RA   Carpenter M.L., Field M.C., Kuo A., Paredez A., Chapman J., Pham J.,
RA   Shu S., Neupane R., Cipriano M., Mancuso J., Tu H., Salamov A.,
RA   Lindquist E., Shapiro H., Lucas S., Grigoriev I.V., Cande W.Z.,
RA   Fulton C., Rokhsar D.S., Dawson S.C.;
RT   "The genome of Naegleria gruberi illuminates early eukaryotic
RT   versatility.";
RL   Cell 140:631-642(2010).
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DR   EMBL; GG738878; EFC42710.1; -; Genomic_DNA.
DR   STRING; 5762.XP_002675454.1; -.
DR   EnsemblProtists; EFC42710; EFC42710; NAEGRDRAFT_80324.
DR   eggNOG; KOG3533; Eukaryota.
DR   eggNOG; ENOG410XR97; LUCA.
DR   InParanoid; D2VKL2; -.
DR   Proteomes; UP000006671; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005262; F:calcium channel activity; IEA:InterPro.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 4.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006671};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006671};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2432   2451       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2495   2518       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2553   2571       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2604   2626       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2679   2701       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      134    190       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      197    254       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      282    364       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      369    421       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED      101    131       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2827 AA;  324775 MW;  A4BB9039F62471D0 CRC64;
     MNQSAKVTKT ATAAVSTTNA ANASTTTVNL ANSSIAMTIS SSANMSGILT SKSTNDMNTS
     SGQLAVNNEE GAVSTSAATR TQYVQAPSVK TFIKSHQYHF LDLTEEQRAQ IEELERKMER
     EKQQNNIEYE RNIGKEILYG QPIQLMHLKT KKYLCVNPRE KAEKQKDCLK LTLVSEEAID
     STSHVIVLPY YKFRSEGDAV KLSDQVRFFN RKSNTFLHLG QFTYSTVLSS NNQLISTSTQ
     VSLDEDDRRE INMIPGTTFT SSFSYTNWRI RLFSPYLSIH SGNMLKAGDV IRLFHTELNS
     FLSVNSKTGR VECVGSANKT SSSTADKALL PIKSNKKSTD DDTSQSKNDK MYAFTDSLWE
     VEMVDPTRGG ALMWNKKYRF KHVSSGKYLY ASKDSHFVEE NEDIFDDFSS DSDDEFGITN
     SFFSKLSRRT TANTEDFDRS SVASASQVNI SVFNESSISL SSTTSSPGNS ATDQYWKLLK
     RKLLAAVKKE QIGVSLELAV KDGLGSDDTT FIICQHDVQS RHDNHHNTAP IPLQSYFRLK
     HAHSQTWVHG VSSDSGIGSS LMKADDTPLK GKNETTPSTP SSTTTNKPTL NLRKQALTQN
     NAANAGMIKP EKKSSRKKFR LYATNVLYEQ DVFSVYKVPQ QELEDLLLVQ SIYPLIESFM
     RRVQSRSIKR PDDFKVLLQT LLPALAQLVC FLTDSDEEDP LKREGIPFKS RQNILRERGV
     IDLVMRLIEE LVDNVPDIVS LSVFGESPAK LGDENTWTES DLASYHYLLR NLYRVIKQSV
     KLNSDNGLYM SKYITEIQQH IKMDVGASVA LIEILTNNYG LLNRMPKEQI RYFVRLLVDE
     ESGGFDENLT SPRKLMVTPR GFSSSPAKKM TPKKEESSEE TATEYLSAKN SIYLSFLSAL
     CACGNRPIKK NQSYITELLF EDEKVTNSLM FPYFVDNDPK NKLCIKVNGT EYGLLEFVSK
     AMSQALSANT ANFDGQDDFL ILLNFFQKQI ELLSLLCLGR NKEAIQYIQN KFSYELILAC
     IKEKNLPFEI RSSFCTLLLN CFLDVDPYEA NPTISFTRKW TEIEKMKKTQ DDKKIKELRT
     FLTDFYKENY QLDCGNDITS VQKNLFIYNL VFMTKKMFEL GMFDLSNIYP THRVVVELLK
     LLDCTNDKLN GKPALDAIYE ENEQTMITTR IKQEVCEIFD IIKSQQLNVR VDFFLINFKY
     SFTVSDKSED KRQDFVKNSL FKDSIFNESA SVQNLTKILI DLTKCKNASL AVKALNLLIR
     IHREKEELKD LLPRIELLVS SAVMKSYDNI LEILKDLKNF INAANSSSGT SLEQYSKSIQ
     QSFKRVEDDY EKNGSRTQRI LRNLSAHELA IETLTMSFDD NRSQQRIHKA CVRFLSDFVR
     KNAENQTILF PYLEFFMSKI GQDLGMSTLI CEVVRNNRGL CSMLEERHIR YLIDLIAEHG
     LKARYLNFLK IILMGTDGNP IKRNQTLVTQ NLLDRKKDVI VLFNDEEGIK ERDRRIKNKE
     HETQPDGILC YHIELLSLLA ECGDGRNHVA EVKLQSLLSI EDILKQLLSP NTIPELRNPL
     LRFLDEVYIN ADKVQDEKQM SSSSPIFRLL AKMARELDMF VNSGGNSNNR RSTEIILTDP
     LDARSVATPI GVGVHPRNTS SQDSNPLELA KTSFVLRLKK PLEGQGDDSL MGHDPEEKLY
     VEIKYIFQLM IPFIHHYFHL KFPPNDFTGE PQQLEVIKAV IENLFNLYQT VAEAAHKEAV
     IKCLQAMCKV SKSGNQSKSM PQEFTQEIFK FLKEASSTKA TQFKQHMQKQ QNKQLVLAQK
     KEDEDEKYMK QYKVYVSGFT TILTQESNFA NLGILLYEQY RGYLDMIVNV IRRISELAPS
     SKDGEIIGKA GSISNLALYS IEMLKQIMNT QQDESVLEKL NAEQRQRKLN KFHHDLAKAK
     IPELVLEMVC SEDHKIMKSS IELGVSMLFE GNNIVQGYIY SLFKKGSTER FFLSIRDRIR
     LSIDEIKERK AYYKRQQEKK QDFKQYRAKK LRRGDNPGTV PATPTAQSSS SNQTDDNEKE
     NEETFQEEFE EKGHIEEILR FLQLMTEGHN NDLQHYLAEQ KYNTQSFNIV EECLNFIVAL
     EKDITADNIE TAIQCFDSLT EFVQGPCLTT QQVIGMSPKF YFVCNEIMSK DYKGVFKLDK
     CLELKGAMFI CLTSLLEGSN NHKIAMIMRD SLNFPDIMEF LKKCCVISFT PTQFIDESRG
     KGLPKIDLNI GAKEEMTSRI QAEVTQDGFR DSFRDKQLTK EKQKRICEAT EQYEEIAFQI
     YFLLNTLSDG ENIFVNDSQS SSKSTFSENS NKKISHLLEV PEYSRYLVPV EKETGRMEIV
     RNNTIENVYY RIPNESSFLS EKSRKNFLTS VNSEEYTAQE KIRNFFDQTD TFYTEIVHYK
     QFESDRNQKV LSSNFIVSFL WRFLREDNWS KIKLLSFLLS LIINCFVLFG FKKMYAVTPG
     DIPLPGYSDP DDSTTGSFQY QGDWKTDWLD YVQTVLGVIQ LVTTSLLFGT YLYFFATLEV
     KKKFKLKMGE KWEDLPRDRQ FYKNYLKYLA KDFYVSFLVV YWVVSVLGLT VNPIVYAIHL
     FEVVVRFDTL YDIVLSIQTT AERFVLTSML MIVAIWFFSL MIFAFVPETF YLKSDNSDKQ
     FLCDSAADCM LNTLNYGLRT GGFFEDQFTP SWGIWTREII NMLFILVVIV VLFEVVFGII
     LESFAELREN REKTEDRLKN KCFICDIERA RFDQKANEGI TFNNHVRKEH NMWNYLFFLI
     HLNRKPKTEY TGSEQYVSNC VHEQDVSFFP ILRSITLENV EYRARLREES SNSTQQGGSQ
     KQSQSAK
//
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