ID   D2VL74_NAEGR            Unreviewed;       903 AA.
AC   D2VL74;
DT   02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT   02-MAR-2010, sequence version 1.
DT   27-MAR-2024, entry version 46.
DE   SubName: Full=Adenylate/guanylate cyclase {ECO:0000313|EMBL:EFC42494.1};
GN   ORFNames=NAEGRDRAFT_80363 {ECO:0000313|EMBL:EFC42494.1};
OS   Naegleria gruberi (Amoeba).
OC   Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC   Vahlkampfiidae; Naegleria.
OX   NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN   [1] {ECO:0000313|EMBL:EFC42494.1, ECO:0000313|Proteomes:UP000006671}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NEG-M {ECO:0000313|EMBL:EFC42494.1,
RC   ECO:0000313|Proteomes:UP000006671};
RX   PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA   Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA   Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA   Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA   Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT   "The genome of Naegleria gruberi illuminates early eukaryotic
RT   versatility.";
RL   Cell 140:631-642(2010).
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-3 family.
CC       {ECO:0000256|ARBA:ARBA00005381}.
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DR   EMBL; GG738879; EFC42494.1; -; Genomic_DNA.
DR   RefSeq; XP_002675238.1; XM_002675192.1.
DR   AlphaFoldDB; D2VL74; -.
DR   SMR; D2VL74; -.
DR   EnsemblProtists; EFC42494; EFC42494; NAEGRDRAFT_80363.
DR   GeneID; 8851987; -.
DR   VEuPathDB; AmoebaDB:NAEGRDRAFT_80363; -.
DR   eggNOG; KOG1023; Eukaryota.
DR   InParanoid; D2VL74; -.
DR   OrthoDB; 3076794at2759; -.
DR   Proteomes; UP000006671; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR013587; Nitrate/nitrite_sensing.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   PANTHER; PTHR43081:SF16; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC; 1.
DR   PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   Pfam; PF08376; NIT; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006671};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        232..256
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        544..565
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          611..733
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
FT   REGION          1..36
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..19
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   903 AA;  101514 MW;  BC6DD23B495FF7CE CRC64;
     MSDKYKQHTS SSGSSSNSSS PHEHHHRATT DELLSNSIDE TSSIQHQRLS SIMNEEQHDR
     NTIVGDSSKV SNKSEDLFLH QHHVSRPESN PPKRNQITPL NLGAMSSSAS KPSLVSVRTQ
     KTLNTNFLLK QGSTMNSLRS SKEISLLQKE KSVSSLSTYS KQAEENDMKG DYLTTLEEGT
     MDTGSRSSYE KNMMGVSSSI SSNISYSVVS KKEARKWTLS KILAKIPLSI KLLLIFIFSL
     ACMIVFEGIL INYSVLRVKE SDANTLLTIF TTGISDIIHE IQKERGSSSL YLGSKGTSFT
     TELDLQRNAT DLQLLNWNAT KKGIIDYFTY AKDETIAKQK VEPTLDMIDA SFHILSAHRY
     NISTLKFPVA KVALDFYTTI IKNMIDIVNV ATSLGRDPDF LIKSNIYSLL MVMKESLGQK
     RATVSNGLAA GAFTNDFYVS YLYLRSRFDT MFTIIDAKSR NVGSFKYFEQ LSLSVNNATV
     TNMMESYILA SPFNLTYAKT IFTAQNWFWN ITQKIDELKT IENMIRDDIL LDQNESEGLA
     IKELIGYTVG GIMGIFLSSI MSLIFSRTIQ DLLRLHNETV HKFVPKEFMS IVQKESVMDL
     THGDYFEMEL DVLFADIRGY TSICEKMTPD ETFEFLNNYL SLVGPVVREH GGYIDKYLGD
     GILALFLTPG QSVLAAMEIQ RRLLEFNKSK KYPTVRVGIG IARGKCAVGL IGEDQRVDPT
     IIGDTVNLAA RLESLTKHYR VDILVTKEVI ETSPLLPKRN QRKIGRLAVV GRQQASWVFE
     ILTRTPSTVS NNSHELKAKN KTNFEDAIEI MFGSYSHGEC VPDKLTIDGQ KHTFGVVDSM
     NMSSTMNNLK SEDVVKAIEL FGKVVSRDPT DFVANMRLEK LREMVDDVSM RSSWAFEDRL
     DTK
//