ID D2VLB5_NAEGR Unreviewed; 1577 AA.
AC D2VLB5;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=RGS-domain-containing protein {ECO:0000313|EMBL:EFC42358.1};
GN ORFNames=NAEGRDRAFT_80427 {ECO:0000313|EMBL:EFC42358.1};
OS Naegleria gruberi (Amoeba).
OC Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC Vahlkampfiidae; Naegleria.
OX NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN [1] {ECO:0000313|EMBL:EFC42358.1, ECO:0000313|Proteomes:UP000006671}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEG-M {ECO:0000313|EMBL:EFC42358.1,
RC ECO:0000313|Proteomes:UP000006671};
RX PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT "The genome of Naegleria gruberi illuminates early eukaryotic
RT versatility.";
RL Cell 140:631-642(2010).
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DR EMBL; GG738880; EFC42358.1; -; Genomic_DNA.
DR RefSeq; XP_002675102.1; XM_002675056.1.
DR EnsemblProtists; EFC42358; EFC42358; NAEGRDRAFT_80427.
DR GeneID; 8851921; -.
DR VEuPathDB; AmoebaDB:NAEGRDRAFT_80427; -.
DR InParanoid; D2VLB5; -.
DR OrthoDB; 5479532at2759; -.
DR Proteomes; UP000006671; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 3.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR PANTHER; PTHR46388; NHL REPEAT-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR46388:SF2; NHL REPEAT-CONTAINING PROTEIN 2; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF00615; RGS; 1.
DR SMART; SM00303; GPS; 1.
DR SUPFAM; SSF101898; NHL repeat; 2.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50132; RGS; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006671};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..31
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 32..1577
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5005670420"
FT TRANSMEM 1118..1137
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1149..1170
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1182..1203
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1245..1267
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1287..1308
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1347..1369
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1389..1412
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1432..1541
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
SQ SEQUENCE 1577 AA; 174627 MW; F449E6050909ED75 CRC64;
MPNPTSLISL LSVAVLLHAL LLLLLSITTT AKSNPSGSFK YSTTSTLLAG GMSLNSLNKY
GDGLDAKMAC LDTIEVVKMG SNNTIYIVDS GHDVIRRISS DGKISQFAGS YAYGYYGNGV
LATLAILANP LDIVEFGGYV YIADAGNSCV RRVNLMTNII EDFVGVCGSS GYGGDNNPME
TIQFNGVMGL AISETGRYMY ISDTSNNKVR MYDMIYRNIT TVAGDGNINT VGAAKVSLGN
PQGLVLDGYT LFVVEAIVGK LTAIDLNTRQ MQTVVYDPTL YPTKLVKFGE TLYMSSANGQ
PILAYEINTA QQAVLNNTGI NSPYAYLIDS FGNVIVSERT RFIYNRTSNA VIAGECSTKY
FVRNNEPTLA NNTNLNTVSQ FIVDKQSGEL RYAYQAAVPF IHKYTNGIST IIAGNGRTDS
FGISYVVGET LAINSPVGTS ISLFENSDNL YFANTTAVMK IDVSGVMTTI IGGYHAHNEV
QYGGLASNSS IKIGSVMMND SKIFIGSVGS IFTVDSNGIL DVFVGNDTLF GKSVNRLSVD
PIDGNIVFYD SVLCNMYKIM QNKSLITLFG KSDCITYSNE TDLTPETYSM RLNHFAFFSN
GDMAILEKSN QCIRRWYRSS NTISTIIGTP GKNEIILFQP NSLSITNDGS IIVADSTIRK
YVISGCTSGW YGKDCLTPVF DVKFYSTVTY TNTSVKVVLN YAESFKSVYQ SATYEMKCKN
QLTTYFNTPL NIQSFTNPLI ISIDKFMKKG NYSCSITATL GTESFTVDFS NTLQVMEYES
VFSESFLKTL PISDVATIAS NKDTYSKSTN VVQVLELVTN AISTLQRNAS NADETLKVTE
ALSVITSQSQ VSSTILNTIS NLAVNISKEL SQLDSNTLKT SSASYESTLS NVLMAYSNCY
SSQNFNISSE SNSIIEKTVM VATRISSQSD SIFQVVTASF IVSVARNINQ SIVSDGNTTV
VTPSELSTLK DISIGSVTYL NVEKLASLIS GSVLSNNYSY NNLIGLAGTS FVNLAKVTDL
KYISNGQVLN VSNLSNPISI KFNVDKSTIE SIQSNSTQLT ISCKYFDETE RLWKTDGCKT
LVDQSNGIID CQCNHTTTFS AFLQFTKYSS IPLTIGKIVV SSILIVLAIV AIVGLIITSR
RNPTKSRWYL PYFALVSLII ELLFSVIIPG SMLLDRSGDS SIVQSVFTMI SCTFYCLSLL
NYLMFNLRYI TFKYVYELMA ILSEKKETQT DTFLKWTKII LTNKFFSIVW NAVIALFIII
YFVIFISLMG RSAIDGDTYT KIMSSSLFAF VMTISLLVCV IYAVDIYMEL RYVQLNSKLK
ETDKKLFINP IKNYFIVNDN LSFRKEFALF FISIAFYVIS NAMGFSYLTS QTSLNARESY
LIVGYIFEVI YNLLLILSFG GLVSIISIYE YLASKKGYTS QIGNEDVEED NQIKDILIQP
ILCQVFEQFA KTEHSLENVI FWKKLYPILE EINRGNIPSM EDLEKEFTEW NENFVATNSP
MEINFSHHIK KSFNSQFELI KSGKIESDDL KETLKDMYCA LMVNLDDTFS RFFITSSYQQ
MNKLFELKEQ MGSALKQ
//
