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Database: UniProt
Entry: D2VLG5_NAEGR
LinkDB: D2VLG5_NAEGR
Original site: D2VLG5_NAEGR 
ID   D2VLG5_NAEGR            Unreviewed;      2713 AA.
AC   D2VLG5;
DT   02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT   02-MAR-2010, sequence version 1.
DT   07-NOV-2018, entry version 45.
DE   SubName: Full=Predicted protein {ECO:0000313|EMBL:EFC42308.1};
GN   ORFNames=NAEGRDRAFT_50531 {ECO:0000313|EMBL:EFC42308.1};
OS   Naegleria gruberi (Amoeba).
OC   Eukaryota; Heterolobosea; Schizopyrenida; Vahlkampfiidae; Naegleria.
OX   NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN   [1] {ECO:0000313|EMBL:EFC42308.1, ECO:0000313|Proteomes:UP000006671}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NEG-M {ECO:0000313|EMBL:EFC42308.1,
RC   ECO:0000313|Proteomes:UP000006671};
RX   PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA   Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B.,
RA   Carpenter M.L., Field M.C., Kuo A., Paredez A., Chapman J., Pham J.,
RA   Shu S., Neupane R., Cipriano M., Mancuso J., Tu H., Salamov A.,
RA   Lindquist E., Shapiro H., Lucas S., Grigoriev I.V., Cande W.Z.,
RA   Fulton C., Rokhsar D.S., Dawson S.C.;
RT   "The genome of Naegleria gruberi illuminates early eukaryotic
RT   versatility.";
RL   Cell 140:631-642(2010).
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DR   EMBL; GG738880; EFC42308.1; -; Genomic_DNA.
DR   STRING; 5762.XP_002675052.1; -.
DR   EnsemblProtists; EFC42308; EFC42308; NAEGRDRAFT_50531.
DR   eggNOG; KOG3533; Eukaryota.
DR   eggNOG; ENOG410XR97; LUCA.
DR   InParanoid; D2VLG5; -.
DR   Proteomes; UP000006671; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005262; F:calcium channel activity; IEA:InterPro.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 4.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006671};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006671};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2340   2357       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2395   2424       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2470   2489       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2509   2530       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2578   2601       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       85    138       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      250    303       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      381    444       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      492    568       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED       55     79       {ECO:0000256|SAM:Coils}.
FT   COILED     1766   1786       {ECO:0000256|SAM:Coils}.
FT   COILED     2601   2621       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2713 AA;  314346 MW;  7CFE80196B931D13 CRC64;
     MISNFQQCVF QVCYPKSYSA LKKYKQHLDE LEIKASGNSA KKSQDNSDND SKKVIHHESN
     EVAQLKERME REIQQNELEA LRNYGKPVTY GSSIQLLHVQ TQSFLTVARE SAEMQKDCLR
     LSLDDVGSKY SHFSLLPYFN YRRDGEIVKL SDKIRIWNRK SAQYVQFSYY RYSNAVESGL
     KNAQSIGSNV NEMDKSSYTQ LAKEAVKNNA NLKKFTYDNR REVNMSASSA FSHWNLRVFS
     PCKDSPTESN KFLKAGDIIR IYHKEFDGFL TVNEKTGRVK LKKSFINPLI GSSANGEASF
     SNSGLSSMKG SGMKSFSSKS SLVSGQYSSS FNLADSFSLS SKSSLSLVDS SENTLSGVIQ
     DDFDVTCHTL WQVEMLDSTK GGELRKNFVY RLRHVSTGNY LIARMATDDE EKKERDAEDA
     EISEFSHSSF YISSESSSSS IQLHNTTSPL SKTPIKTKKE NNLSLFVEPQ DNCTNPLNML
     FNLQDSMLST DHSEFFLNGQ FRLRHYLTNT WLHSVNSQKA FSKSSERASL KSHYSPVCTT
     QGMREEDVLT CVLVSRPESE DLFTVQSYIP ILKYFTQKLN DGSVNRSDIK LYIDVISSCI
     RFCTSSSEMD PLLRSGIPIK KNQKLMREKG VITIVMDILM ALISKNYVKL EELSTIQERS
     DKIDFFDVIQ YSYRFIRQVV LTNESNGLFM AQYINFIQTN IEHSISASEA LLQILSNNFS
     LLNKITEDQI DFFIKLLFTN PTSSSSLKQH TERYGGSLKK AVYLSFLTSL IICEGKTVVK
     NQKYISNLLF STFKEQMLKV FVIPRIRKSD DKVIIDVNRV EYELVNFSKS ATNIDHITYS
     KNNFELMVFF QEQIKLFAAM CTGSNEATEM TRAAIIQLFT FEIVYKCVAE SALTPALRTS
     FVHLLMHCFV DTEKNEKRTF IELTRKLESL SGKSVHEYTS RELGEVKQFL EVFFRENTSL
     DIGYEKRDVN NFILSLAQLC AGMIEFGIFN LKDFEETDLL VSLFNILRSD NDTKNGLPLR
     DEERFKQSEE NVTVTQIKIE IAKIFHMLLD LLLDKRITKF LQFFWMKYKI DDIKIVIEEE
     SDSLLGVTSN DKQQAQLLNL RKKELDRIFQ EMDTKENQVL KDIFENTTLP FKIMSEFSLK
     IINLTSYENQ ELSTICLRLL IRRYRAADEL AEALPKVELI VSREMARSYD HLRKQTADLR
     SIFGYGRSNF LGARHISEYE VKKAMKALGE VISDIKTNGK RSQRIIRNLN LFELVLSVLR
     KEWMVPTDIQ ENCLTILTEF VRGNPDNQKL LFPYIEFFMR LITENKKLSK YIVLLMCEIV
     KNNRTLCSIL EEKLIEQYFD LIAEQRSAFM LLFLRTILAT HNNTPIKRNQ SLITKYMVER
     KKDVCVLFKD EEGMRERNNR ITKEEHKTEP DGILNYHIAL LHLMATAADG KNRESELRLQ
     TLFSFEELLE QVVSPFTLAM IRNPLIKIIN EVYINVEKAT DDHQEKKTAN VHHPLMYKMF
     SKMIRELEFV EMLQTLDVNA IVGSEGATNS PSPSGTGASL SASSATKLSN ASVRPSMNLT
     NQALIRQSRA ITNRNSSIAP KMQVTEEDLE KFHVDNYYIF EVMIPVVQNY FHLHFPPPNL
     LKEQLDVAED LLLKLIDLHK FTANTDQREQ IYKCITAMWK KSMSSESQLA ITKFVTNKNT
     KAKMTRSRFE VSSTVETDEY IHKSYTKYLQ KRIINKVEEF SHFNRIGALF EKYNGFVKVL
     VRALRKINTP LLNYSPSLLE VGLLSMEILK DIVRSQNKRA KEVKQKGEND VPEIENLNYV
     ENKLPVMIIE LMTSFNPAIV RSAIDLGILI LNRGDKAIQD EFYRILTETD SSYFFESLRD
     RIRLGKTEIK ERKNYLKKKR DKDYALFKQR QRQEVAKVRA KDENDSSRPM EEEEERDLQE
     DFVEMGHIEL LFEFLRLLCE GHNVEMQTLL LNQPVNTLNV NVVTETIEYM IALEKKIDFD
     NVQIAIQGFK TLTEFIQGPA LVIQQAIGTS PRFYARLVNE IMSKTYEDGN LLKQQELGLK
     REVLLTLNAL LEGMNNSVFD FMRHSLNFDE LEHFLLFSAR FLHSLETKHE NSDAKDEYNE
     IKQRLRRDFD HHFLHEATRD KANPVIAEDY IAVYMPMIKN LLKETGNFAF FLLNIFRDGE
     RENLRNISRS AFISVEEENK LLRITNMLDN HSQLVSVFSE STASIEVLRD NKIEKIYFSK
     PTICNNLMDK ARSNYVNSLD VMAPEEKVRT LYNHTFSIFQ VEMEHYELMK KKSTIKDKLE
     DLVGIANKHT EEVTEFVPTM AQLRNKYKRK KKLSIGTSSK NRDQTASWEF IAHWWDRIRL
     LSFIFCVVLN IFVLGFLKRL YSANTVDDIP VPGDLDFDIT LASKYPTTRN LAGDIIITIL
     GAIQLITTAS LAIIYAKVFI TLEVKKRFKL KKREKWENIP RNREFYWKFI FYALQDLQMW
     FFVLYFVLSV LGLLISPIVY SIQLFEIVFR FKSLNDVLRA VISNGKKLFF AGMLLGITMF
     LFGLLFFSWF SNDFTLESNG TKTCESVLEC FVTMFDYGFR SESSWENMYP HNPTVGRAIL
     DLAFNMIVIV YLSNVVFGTI LDSFQELRAA REERKNEIRE KCFICALEKS KFDTKANEGI
     TFEKHIKEEH YLWNYVYFLI YLYEKPETEY TGVESYIFEK CEENDDVTSF FPIFRSKTIE
     ESEQTKVSLG GSD
//
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