ID D2VMD7_NAEGR Unreviewed; 793 AA.
AC D2VMD7;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN ORFNames=NAEGRDRAFT_50744 {ECO:0000313|EMBL:EFC41970.1};
OS Naegleria gruberi (Amoeba).
OC Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC Vahlkampfiidae; Naegleria.
OX NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN [1] {ECO:0000313|EMBL:EFC41970.1, ECO:0000313|Proteomes:UP000006671}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEG-M {ECO:0000313|EMBL:EFC41970.1,
RC ECO:0000313|Proteomes:UP000006671};
RX PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT "The genome of Naegleria gruberi illuminates early eukaryotic
RT versatility.";
RL Cell 140:631-642(2010).
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}.
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX5/DBP2
CC subfamily. {ECO:0000256|ARBA:ARBA00009334}.
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DR EMBL; GG738882; EFC41970.1; -; Genomic_DNA.
DR AlphaFoldDB; D2VMD7; -.
DR STRING; 5762.D2VMD7; -.
DR EnsemblProtists; EFC41970; EFC41970; NAEGRDRAFT_50744.
DR VEuPathDB; AmoebaDB:NAEGRDRAFT_50744; -.
DR eggNOG; KOG0327; Eukaryota.
DR InParanoid; D2VMD7; -.
DR OrthoDB; 5473705at2759; -.
DR Proteomes; UP000006671; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR025197; DUF4116.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR47958; ATP-DEPENDENT RNA HELICASE DBP3; 1.
DR PANTHER; PTHR47958:SF57; ATP-DEPENDENT RNA HELICASE DDX1; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF13475; DUF4116; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM00487; DEXDc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000006671}.
FT DOMAIN 429..604
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
SQ SEQUENCE 793 AA; 93430 MW; 51E1FDE8A72EE8A2 CRC64;
MLDREQLVFN VDVAFIVQSF LNDSDRRNCE QVSINFHRAC NTLERLEFRD RLQNVELNLI
REKFDKSSIA SSPKRVFSSA EEVFNEDIEM EIEAFERKHI KIPFHLKEYL RMSVHLDPYL
ILDILKEYVF MHPLTVLCPL SDWIVIREGE EYLIGEFSNS SGRESFIFTL NQKQNGKCSI
FMTITKNNNF GYDQIISYTT KKRVEIGTLK RWFNNYGFGW FVNRNIFHYS FHNSLQRNHL
DLFQISRNTT SSFNSQHIYN LIKNYKFVFP GALMEKYSID LLREGLITLK QLKENLRKDP
RIIDMAVRCN GLNLEFVGKE YHRNEEMVRK AISQNGLALK FASKSVRMNK DIVEMAYRQN
KYALKYSLLS PKEDSKTISD RFLKYFSFNQ DPNCEIETLF PNNDYLLRCI YGFGLEYFSQ
YQVDMIKRCQ REDNTAQNIL FQAPSVGKTL ASLIVALERI QKFKSILGSG IHCLILCPNR
ELVIKVARLF SSLLMWNDIN IITAHGGHIE KLYFYNYETY MPCTPMEVDF SRKTETSPNP
SILIGTPGRL ALDDLRSGMF ELNKVHTIIY EEADTLLSGE YDSLTHIMRE IEEYNPNCKL
MNIVLCQTLT ERMYFKMNTT FNQNLEYFYK EEKFAFLKPL SLLRGFIDHE IVSVEDLSDT
EVHNLKLDLL KKNGDEIPLL VAFGNRRSIE RYIDGNQSIL ISILHSDMEQ RDRELVWKEA
NELTCQVLST TDINSNAMLL TREIHTVFQF DFPSSEEIFI KRIRYALFRE NKMKVITFVN
SKKQERRILK WLR
//