ID D2VMP5_NAEGR Unreviewed; 1041 AA.
AC D2VMP5;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Predicted protein {ECO:0000313|EMBL:EFC41867.1};
GN ORFNames=NAEGRDRAFT_70212 {ECO:0000313|EMBL:EFC41867.1};
OS Naegleria gruberi (Amoeba).
OC Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC Vahlkampfiidae; Naegleria.
OX NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN [1] {ECO:0000313|EMBL:EFC41867.1, ECO:0000313|Proteomes:UP000006671}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEG-M {ECO:0000313|EMBL:EFC41867.1,
RC ECO:0000313|Proteomes:UP000006671};
RX PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT "The genome of Naegleria gruberi illuminates early eukaryotic
RT versatility.";
RL Cell 140:631-642(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; GG738883; EFC41867.1; -; Genomic_DNA.
DR RefSeq; XP_002674611.1; XM_002674565.1.
DR AlphaFoldDB; D2VMP5; -.
DR STRING; 5762.D2VMP5; -.
DR EnsemblProtists; EFC41867; EFC41867; NAEGRDRAFT_70212.
DR GeneID; 8851357; -.
DR VEuPathDB; AmoebaDB:NAEGRDRAFT_70212; -.
DR eggNOG; ENOG502QPZM; Eukaryota.
DR InParanoid; D2VMP5; -.
DR OrthoDB; 276814at2759; -.
DR Proteomes; UP000006671; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR InterPro; IPR004680; Cit_transptr-like_dom.
DR InterPro; IPR006037; RCK_C.
DR PANTHER; PTHR43652; BASIC AMINO ACID ANTIPORTER YFCC-RELATED; 1.
DR PANTHER; PTHR43652:SF2; BASIC AMINO ACID ANTIPORTER YFCC-RELATED; 1.
DR Pfam; PF03600; CitMHS; 1.
DR PROSITE; PS51202; RCK_C; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006671};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..33
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 34..1041
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003038715"
FT TRANSMEM 259..277
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 284..301
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 313..333
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 447..470
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 843..865
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 871..890
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 897..916
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 936..963
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 975..994
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1014..1036
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 720..812
FT /note="RCK C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51202"
SQ SEQUENCE 1041 AA; 118387 MW; 8F6F98FAD6C6FD31 CRC64;
MKSIGSHSFT FESSSSLLIV LILTLLINEQ LNAFQFSTQF TKNQLVWSDD RHQYVNSTQK
VGFVTLSFSS TKNTLAWEII YPKVADSQVM NSSNLNTTLT FSHFRLIHNN ILNSNTSKQL
LLPSSDFFDY RAKRNDDGLD LNYEKMFFNL NGNQVSLVSD SIEISELYKN KYYMQWFTLQ
LNITHLRMEL PYLVVLNQTF TLDYYTNQLL NQIKQSNYTY STLKLLNSSL LISDVKTSEP
ITNICSSSSP IIPFAWNSWK LWVVVAFLLL MLTLLVLTVW RPYVVILFTI VIFNLSGILT
LDQTLSGFAS SGTLVIALLF PIVKAVTQNS LVLKFSKLLF GSPIKFKNME KSKVLQHLSL
LVPTLRICLV FSLISAFVIN TPVVVLGLPI VMEWARQHKV SPSKFLMTLS FIISGSGFLT
SIGNSPNIVA NELYTSYGYR ALEFYEFVYV GGILCVVTIV YLITYGLWIV PDEIRGESKK
LKRINVNFAK KIKKLRNKTK ERMEEFIAVV RMNQLSSQKH HTKPYMLFMN MLGRNEEKIL
KVLELDNIEI VEVIRKCEKK VEETKTQKKM ESIQNTSPAN AETISIEIDM AKIETDTSEE
TIRIKPVPKD LVIEKDDILM FKGNPKSILK LQSMVFEIEE YKEVSLKPYE YRLSTINPSI
QEFTQMRGSQ LSLISQDSNE NSTISSGGGS DQNDIITKLY SNLKRNHPKK NESSKAETSK
ETVVEETSQL EYFEVVIGNS NPCVGETYQI FELRYQVTVL AIRNMFYEEK ESETAENDLR
TFQVNTGDTI LVIGKPRFYT NHHNSTREFY MISRFSEVSP TDNQFIQRPF QFRIPFTKKV
FRLWWWENWI FLFFAAMIGC AIYGYPMVQC SLVTFCVIIL FGLISPTDAL ESVDWGLVIL
VGSSIGIGTA ITQSGIGQGI TQVLKMANVP IILLPAFITF ITLIIAHIIT GSAVVAICIP
IAVSIAQSYG LNARCFVMCV IYASQSVFAF PLGFSGNMLV MGVGNYKFLD FFKVGLPLTI
IYWILISVLV PVVWGLTLPN F
//
