ID D2VMX3_NAEGR Unreviewed; 623 AA.
AC D2VMX3;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Predicted protein {ECO:0000313|EMBL:EFC41898.1};
GN ORFNames=NAEGRDRAFT_50875 {ECO:0000313|EMBL:EFC41898.1};
OS Naegleria gruberi (Amoeba).
OC Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC Vahlkampfiidae; Naegleria.
OX NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN [1] {ECO:0000313|EMBL:EFC41898.1, ECO:0000313|Proteomes:UP000006671}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEG-M {ECO:0000313|EMBL:EFC41898.1,
RC ECO:0000313|Proteomes:UP000006671};
RX PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT "The genome of Naegleria gruberi illuminates early eukaryotic
RT versatility.";
RL Cell 140:631-642(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the LIMR family.
CC {ECO:0000256|ARBA:ARBA00010487}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GG738883; EFC41898.1; -; Genomic_DNA.
DR RefSeq; XP_002674642.1; XM_002674596.1.
DR AlphaFoldDB; D2VMX3; -.
DR EnsemblProtists; EFC41898; EFC41898; NAEGRDRAFT_50875.
DR GeneID; 8851499; -.
DR VEuPathDB; AmoebaDB:NAEGRDRAFT_50875; -.
DR eggNOG; KOG2296; Eukaryota.
DR InParanoid; D2VMX3; -.
DR OMA; KYTSYVM; -.
DR OrthoDB; 1068841at2759; -.
DR Proteomes; UP000006671; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR006876; LMBR1-like_membr_prot.
DR PANTHER; PTHR21355:SF0; G-PROTEIN COUPLED RECEPTOR-ASSOCIATED PROTEIN LMBRD2; 1.
DR PANTHER; PTHR21355; UNCHARACTERIZED; 1.
DR Pfam; PF04791; LMBR1; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006671};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..45
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 52..75
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 102..124
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 300..318
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 350..372
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 392..411
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 438..460
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 563..604
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 567..595
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 623 AA; 71975 MW; 61D00445F17CBAD7 CRC64;
MKPDPALVTM WRVIYWTLQV LSWILLPIFQ SYLYTGEFLA IFRWLRAILD NLITYSIMLL
VGGLGLGGFC IYIAISNAND PANAQIISLD LIAGLGLSLS NIYGLVLLVG FIGYGIIAVP
RYLWETSNDE RQLQLYEFTT PTIVEELEEL ENELLDYLGV CKILERKVDS THKQFKNVER
IMMTVEEVIR DHPQLNKAIR RSTSRDVDDG LLPKNIEDLS RSDCVKIHRL LQKAIREFSS
KQYQWKHLQK KAFILQDVIH SKENSSDMKV ASPFRSPRPK VVQTIIEKPE WIYVKYLRSL
LLKLLALAFV PFGLIIMWCE FTPLFKNIYA TKRLSLSILE LIIMSMRDRF AIQIVALLIL
GLILVTLLFA MYRVRILYLF QMVPHHTDSY TLFYTALLLC RAIPTMCFNF LQMVGVDPDD
GVAYFAIYGA LRVDGLRIFG LLGGFIVDYF PLLIIVVAFI TMFKLIERCG TLCNIQRFSY
TGSNMSDETI LEGREILHRA RAKKLRQLQN VSAEKISSSF DKLEENDLRS AVNISLDENE
DFETRIEIDD NIKLVEVNED NYDYDDFSEP QETKSSHKSR LDRVYEKHGR ERPNPNDYSK
NTSFTDTIKN KLKSAKKNFD SVL
//
