ID D2VPG5_NAEGR Unreviewed; 1444 AA.
AC D2VPG5;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Predicted protein {ECO:0000313|EMBL:EFC41354.1};
GN ORFNames=NAEGRDRAFT_58846 {ECO:0000313|EMBL:EFC41354.1};
OS Naegleria gruberi (Amoeba).
OC Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC Vahlkampfiidae; Naegleria.
OX NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN [1] {ECO:0000313|EMBL:EFC41354.1, ECO:0000313|Proteomes:UP000006671}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEG-M {ECO:0000313|EMBL:EFC41354.1,
RC ECO:0000313|Proteomes:UP000006671};
RX PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT "The genome of Naegleria gruberi illuminates early eukaryotic
RT versatility.";
RL Cell 140:631-642(2010).
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DR EMBL; GG738886; EFC41354.1; -; Genomic_DNA.
DR RefSeq; XP_002674098.1; XM_002674052.1.
DR STRING; 5762.D2VPG5; -.
DR EnsemblProtists; EFC41354; EFC41354; NAEGRDRAFT_58846.
DR GeneID; 8850719; -.
DR VEuPathDB; AmoebaDB:NAEGRDRAFT_58846; -.
DR eggNOG; KOG0618; Eukaryota.
DR InParanoid; D2VPG5; -.
DR OMA; EWDERIK; -.
DR OrthoDB; 5476564at2759; -.
DR Proteomes; UP000006671; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR CDD; cd19978; PBP1_ABC_ligand_binding-like; 1.
DR Gene3D; 3.40.50.2300; -; 6.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR028081; Leu-bd.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR47235; BLR6548 PROTEIN; 1.
DR PANTHER; PTHR47235:SF1; BLR6548 PROTEIN; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF13458; Peripla_BP_6; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 3.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006671};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1191..1215
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1233..1371
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
SQ SEQUENCE 1444 AA; 160512 MW; 27FD013CCE2E72F6 CRC64;
MTGVQAAFKE INENSGGVWG GKKLRLITLD DGYEPARTVN NTIQLINNNT IFGLIGYMGT
GTSQAAFPYL TESKLPFIGA FTGGLFLRTP FVSNIVNIRA SYQDETVAMV EYLVTVKMVR
RIAIFYQNDA FGMSGVDGSS LALTALGMSL VSRGSYERNT IVVAKAVSDI VAGNPQAIIC
MSTYKPTLEF INTVKNRTDF DPNIVFMTGS FIGSNILPYR DSVVITQVLP PPTNTKYPIV
LAYQRAMKAS NPNFVPSYVE LEGYIAGKMA ANILTQRVSG DLTRSNFLQL VYSTSTYIID
NQVIGPYKQC SSSRSLHYFF DDPQNQDAFL YPVLQPRTRL IPRKIESTFV APCSCNQGLR
SIWKTSQNAD SSFSEISDPM VWDTTSTTNY TCFYDPTKTL PPIVFGHISS GDKYDEDFLV
GVLLAFNEKN NQKGIRGSVL RILTKTPSNS SASALIDTVN LLKNDFNVLG ILGGFLPSSS
YAQFVDQFKT QLPNTLFLSP STSYDSPTLR SVFSPNIIHI GLSIREKLAT FFDFEMNANG
HSRFSVVYGK STEGAADCKE FKNQLSQFGL TVESEYEHSS SVTDYKLVTQ ALVSNDGNPQ
SVVVLLPENI SSFSYLSTVI KGIVNIGKRD DLSIFFLYFK YTSWVADVFN LMASLNTKNN
VYLIQRYPHV VDTQLPLVAA YNNLFSKYYS SSVSTTGSLE GFLAASFLIE VLENISPSAD
INGPSTIFTI YQTQQFLKYS IPFGNFISNS CNLGMRTTYL YKLDGSTFTN VKIQSFDKTK
CGLSEDIFSS ESSIEKQLLF GRLLPVEDAS LPYDDFSVGL NALFTSYNTK GTLDTATLHL
KTLYYSSREE MTKKAEELIL KYKIFGFLGS RLVYDVTELK AIMENYKIPI IGPLSSQLAL
REPYSRFVVN LRPSIVEESV VLTRYLTSVI TSRKPTVLIL SGSSYYWQQN SNNVVSFYSK
SIEGVSISST SISSVSSTSG RAVEGSKPDL VLLLASPTEV SQFLTNYPTF SSLIGIPSEI
SSISSFKTLL NDIPSSVIIS PQFLERYDKA SSTNFMARDF LIDMAKYSTS SNTSTLMYEA
YAVGYMTTTV LKFMSQANMD YSREKFVSTF FERSVFELGN NEFGPYGDEC SIQSTFVVKG
SCESVSVCNC SQGVRALQIN SLTSSSDSIL YEMNFKTCGL QAIEPLLSDG AIAGVAVGGT
LAFLGTLFVI LVLIFCARNR SSVKNAPKSG NITCAFTDVQ SSTKLWQNNE KAMRNALEIH
DKIMRKNLEL FRGYEVKTNG DSFFVAFKDP FDAVLWSLTV QLDLLNANWP SELYHEYDCR
QEWDERIKKP YWSGLRVRIG LHYGKGDCKW DKTMKRFDYF GTVVNKSARI EALAHGGQVL
ISEELLEVTK DLFQDVKKIA SCDEFPAYQT TTKEEKKLAV DDKTSTTASL KHQNSLSSVL
VDYV
//
