ID D2VT07_NAEGR Unreviewed; 733 AA.
AC D2VT07;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Sodium:neurotransmitter symporter-like protein {ECO:0000313|EMBL:EFC39999.1};
GN ORFNames=NAEGRDRAFT_81122 {ECO:0000313|EMBL:EFC39999.1};
OS Naegleria gruberi (Amoeba).
OC Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC Vahlkampfiidae; Naegleria.
OX NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN [1] {ECO:0000313|EMBL:EFC39999.1, ECO:0000313|Proteomes:UP000006671}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEG-M {ECO:0000313|EMBL:EFC39999.1,
RC ECO:0000313|Proteomes:UP000006671};
RX PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT "The genome of Naegleria gruberi illuminates early eukaryotic
RT versatility.";
RL Cell 140:631-642(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; GG738895; EFC39999.1; -; Genomic_DNA.
DR RefSeq; XP_002672743.1; XM_002672697.1.
DR AlphaFoldDB; D2VT07; -.
DR STRING; 5762.D2VT07; -.
DR EnsemblProtists; EFC39999; EFC39999; NAEGRDRAFT_81122.
DR GeneID; 8850984; -.
DR VEuPathDB; AmoebaDB:NAEGRDRAFT_81122; -.
DR eggNOG; KOG3660; Eukaryota.
DR InParanoid; D2VT07; -.
DR OrthoDB; 3084493at2759; -.
DR Proteomes; UP000006671; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd11554; SLC6sbd_u2; 1.
DR InterPro; IPR000175; Na/ntran_symport.
DR InterPro; IPR037272; SNS_sf.
DR NCBIfam; NF037979; Na_transp; 1.
DR PANTHER; PTHR11616:SF279; SODIUM-DEPENDENT SEROTONIN TRANSPORTER; 1.
DR PANTHER; PTHR11616; SODIUM/CHLORIDE DEPENDENT TRANSPORTER; 1.
DR Pfam; PF00209; SNF; 2.
DR PRINTS; PR00176; NANEUSMPORT.
DR SUPFAM; SSF161070; SNF-like; 1.
DR PROSITE; PS50267; NA_NEUROTRAN_SYMP_3; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006671};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 136..155
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 167..189
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 210..239
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 273..292
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 304..324
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 347..372
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 384..407
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 444..464
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 480..500
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 621..639
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 659..681
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 72..130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 704..733
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 75..93
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 114..130
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 704..719
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 733 AA; 82747 MW; 1C58FDD285346067 CRC64;
MSSDHQQTRH RVGQHVDDGD DDELMSTDNG LSNNHQHHHH LQEGDHHNII IKHNHHEHGS
DDDLELKNQQ RNRSEEDLGL NYSQSMNTFD ENSNMINDEE ESNEQDSSEK RKESSTIPTT
PAPTNNHQRQ QWGSRLSFIL ATIGAAIGFG SFVRFPYLAY KQGGGAFLIP YTVCLIVLGI
PLLILELSMG QLLRKSSIKA LGLLNNRMRG LGVAAVLFGG FGICTYYSVL ISWIFVYFYH
MFAWELPWKG KTEEYFYDVI LRRSSGDTVV SELNIAITVS LFLVWVSVYC GVWKGTSSTG
IITYITVPLP ILLLLILLIT SFFLEGSWTG MYYFIKPDFT KILNVEIWLT AAGQVFFSLS
LASGTMIALS SYNDPKQNIV KDAWIIGLST YIFSIFAGFC MFAILGYMAH SKGVEIDHIV
QGGLALAFVV IPEAITLMPA SHVFCILFLV AMYTLAIDSC FGMIEGVNAV IHDAFPNLKL
HWISLVTCFL GFIFGIPYCL DNGYYLMDIV DHYLSDFCLV LSAIGQCIVV GYLISDESVI
ARVRKQWREY SSSSYANVEE GNATPIDSSE QPATRPTPQW KLRVKKYLSL TDTILFHSID
EFRLRIKKVC NFGPHKEWSI FIKYIGPIIL LILLIIQLVK EITSPYSTKG SDSKEFDWLS
LTIGLCIIFG YLGTFTIFAI FPRLATQKSE DPGNSWRAVL DKYEKEDSEK EEESKTNNLE
EELQNVVPST PQE
//
