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Database: UniProt
Entry: D2VTL3_NAEGR
LinkDB: D2VTL3_NAEGR
Original site: D2VTL3_NAEGR 
ID   D2VTL3_NAEGR            Unreviewed;      2753 AA.
AC   D2VTL3;
DT   02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT   02-MAR-2010, sequence version 1.
DT   07-NOV-2018, entry version 37.
DE   SubName: Full=Predicted protein {ECO:0000313|EMBL:EFC39952.1};
GN   ORFNames=NAEGRDRAFT_52142 {ECO:0000313|EMBL:EFC39952.1};
OS   Naegleria gruberi (Amoeba).
OC   Eukaryota; Heterolobosea; Schizopyrenida; Vahlkampfiidae; Naegleria.
OX   NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN   [1] {ECO:0000313|EMBL:EFC39952.1, ECO:0000313|Proteomes:UP000006671}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NEG-M {ECO:0000313|EMBL:EFC39952.1,
RC   ECO:0000313|Proteomes:UP000006671};
RX   PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA   Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B.,
RA   Carpenter M.L., Field M.C., Kuo A., Paredez A., Chapman J., Pham J.,
RA   Shu S., Neupane R., Cipriano M., Mancuso J., Tu H., Salamov A.,
RA   Lindquist E., Shapiro H., Lucas S., Grigoriev I.V., Cande W.Z.,
RA   Fulton C., Rokhsar D.S., Dawson S.C.;
RT   "The genome of Naegleria gruberi illuminates early eukaryotic
RT   versatility.";
RL   Cell 140:631-642(2010).
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DR   EMBL; GG738896; EFC39952.1; -; Genomic_DNA.
DR   STRING; 5762.XP_002672696.1; -.
DR   EnsemblProtists; EFC39952; EFC39952; NAEGRDRAFT_52142.
DR   eggNOG; KOG3533; Eukaryota.
DR   eggNOG; ENOG410XR97; LUCA.
DR   InParanoid; D2VTL3; -.
DR   Proteomes; UP000006671; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005262; F:calcium channel activity; IEA:InterPro.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 4.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006671};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006671};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2379   2402       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2439   2466       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2503   2526       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2552   2573       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2626   2645       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      253    306       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      411    482       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      487    576       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      603    654       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED      223    250       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2753 AA;  319519 MW;  1D66D9F91190A851 CRC64;
     MTLSNNHNNS NSSEPSSQHL FDYALLFHQQ QEQLIVSVSA TSAVKNNGAT SNHHHEQHSE
     YSSSSSSSAQ QQQGFDHHLY DEDEDVMSDV KEDEQQLWMN NMMMKKKGDY LRIGEEISFY
     TDLSSKSTGN SMIGFLSVDG INLTCSENVK GNKPQARCGL VESVISEKDS SFFTPNFSNC
     VFKICHPKSY SALKKFKTFK EEQELKEANK KTKDNKNNVM PSTASFSTEY QQLEQRAERE
     LEQNRMESQR NLSKPVVYGQ TVQLYHVQTQ CYLTVARESA EMQKDCMRLA LDKEGSTYSY
     FQIMPYSSFQ KDGDQVKLTD QIRLYNKKSN QFIHLSYYRY TTGEDNDGTY QRVNENSSYT
     ELAQQAVKLS RNRGKYSYDS RREVNMANST AFTRWRMKLY QKYTPQNDET NRKLKAGSTI
     MRIYHKELEG YIGVNEKTDR IKFFKKSSNL QINDSEDTSL AGMESKSSDY VSPQTLWQLE
     FLDSSCSGTV KWTSKFRLRH LASGKYMVIR PIKGITIEAD DAIEERYERE NTPTSGDNLS
     QLGVNAPRKS SIVATPRGNR SGSVTQNDSL WTLHVENFDD LITQPIPTSV FHFTDSTGGQ
     KKGEKVQTTD YFRLRHEATN SWVHISRPLA DSTYQRVTSS LKMFEQDVFN FSAVSHEDLN
     DALTVAGYMP IIRYFKSKLD DSLIDKSDIK LYIGALANCI RFCTISEETD PLTRGGIPVK
     LRQNIIRDMG VIGLVMENIT LLLKKYLSIE DLSLIYEKPE KALYFDVVQY SFRLIRQFVL
     SNESNGLYMA QYINFIQTLI EHSIAASEAL LEILSNNYPL LNKITESQID FFVKLLFENT
     SKIGMRQSSK SLKKAVYLSF LTSLIICEGK TVVKNQVYIG NLLFSKYKDQ LRRVFIIPKL
     NNEDKVVVEV NHDEIDLISF SQSATDDTYN GYTRPNYEQL IFFQEEIRLF AALCTGRNEE
     IEDARRSVVS LFTYEVVHKC VSDKNLTPAV RTSFVKLLIQ TFIDTEKREK KPLIDYTRKT
     STLNQRSKED GNSKDLAEIK DFLGKFLREN VSLDVSLEKK DHNNFTLYVV IMCKRMLEFG
     VLTLIDFEEG DLLNSLFDML RGDNDKKDGR ILSEEERHKN VEENLTLMKI KIEIASIFHM
     ILDIILDKRV TKFLQFFWKK YREEEIETVL REQEVIPMDN RALQQKRLAE IDSNEYAVIK
     DILEKDVIFN KMDRFDVKIL SLTKYENKEL ATTCLDLLIR KYRSAQELCE VLPKIELIVS
     REMAKSYDLL LSQVVELRSV FGYGQSNYFG TRRLTEQEEK KVLKALNEIL SDIKKNGQRS
     QRIVRNLFIY DIILTFLKKD YIVSKEIEEI GIDILIAFVR GNQDNQKIMF KQLEFFIHTI
     GENRSLDKKI VILLCEMVRD NRGLCSTIEE KLIEHYIDQI AEQPCSFMLL FLHVILGTNN
     GNPIKRNQSL ITKYLLERKK DIMILFKDEE GLRERNQRII KGEHKTEPDG ILNYHIALLY
     LLASLADGKN RESELKLQTL YSYEELLEQV ICCTLPVLRN PLVKVIDEIY LNVEKASDDS
     TESESKMVNV HHPMLFKLFS KMVTELEVLE MTYSNESDGN DLILSTQKGE RQSIMHAHTR
     TPTTPSKTLS NTSLFATPTK NRGLSTTASK RSSKTYSVAL PKVVGPSEED QETYQVDNTY
     LFDIMIPCVR DYFHLHFPPP NLTKEQLDIA EDLLIKLIEL HKHTPNPENR DKVLKCIQAM
     LKRSMSSTSQ KAISNFISNK ATKAKVHRSR IQTSTSTEKD ELIHNTYKKY LKDRIISKIN
     RNFSNFSELA AIFIKYDGFI KTLVNVLRDL NSSGLLLQNM KVGLFGMDIL KSIVERQNQQ
     TEESTLKLDL VEKKIPEVVI EFLNSNHHQI AKSALELGIL ILNDGDLDVQ NHIYSLLTDQ
     DSTEFFMSLR DRIRLSKIEI KQMKNHLKKK RDKELALANQ KKSTTNLNAD HDNEEDEVGV
     EFVEKGFIFN TMEFLRLLCE GHNTKNQALL KHQPRNIFSF DLITEIIEYL IALEKKLDAD
     NVQVAIQGFK TLTEFVQGPA VFNQNLIGTS NKIYPRLINE IMSKTYDDSK LLKEQELDLK
     KEITLFLISL LEGRNTVTLE FMKNSLNLDD FEQKLLYILR LFETLSGNNH DDCDDLERLK
     KRMRKDFGFH VLYQSEKSSK KPIRVDDYME DNLEKIRLQY DDLGTHIFFL LSMIRDSETE
     FRKGTQALEE ESRVANFFQT NSKELSYFKQ RTGSIEVLRN NVLEKIYFPK PTICNNIIDK
     ARSNYANSLH VMTPQEKVRK LYNDTFSTFY VEMCHYENMK KTFTIPNLNK KEEEEPEEEM
     ENLLPSMSLV ATTSNLLAKR KKKKKQEVKT ASWEYIANWW DYLRLSSFFL SVIINIIVLG
     TFKRIYATTE YSQIPLPGSD FDVYALTKTT APRNLASDII LIIVGVTQLI FLVILFVIYV
     SLFLTLEVKK RFKLKKNETW DSIPRDFDFM TKCFLYTIQD SQIWYFIIYI VVSVIGLLIT
     PIIYSIQLFE MVYIFKSLTD VLKSVTSNVK RLFFTGMLLC IALFFFGTLY FTFFSSDFKI
     SKTGDKTCED MLACYVTMLD YGFRGESFWE DIYDPNVSVQ RAILDLSFLV IVIVLLVNVV
     FGVILDSFEV LRNEREDRKK DIRDKCFICG LERTKFDTRA NEGITFEKHV KEEHYLWNYV
     YFLIYLYQKS VTEFTGTEQY IYDRCEDNDD VTSFFPIFRS LSLEQSEQSS KVE
//
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