ID D2VUD6_NAEGR Unreviewed; 2320 AA.
AC D2VUD6;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Dedicator of cytokinesis 4 {ECO:0000313|EMBL:EFC39674.1};
GN ORFNames=NAEGRDRAFT_81257 {ECO:0000313|EMBL:EFC39674.1};
OS Naegleria gruberi (Amoeba).
OC Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC Vahlkampfiidae; Naegleria.
OX NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN [1] {ECO:0000313|EMBL:EFC39674.1, ECO:0000313|Proteomes:UP000006671}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEG-M {ECO:0000313|EMBL:EFC39674.1,
RC ECO:0000313|Proteomes:UP000006671};
RX PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT "The genome of Naegleria gruberi illuminates early eukaryotic
RT versatility.";
RL Cell 140:631-642(2010).
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00984}.
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DR EMBL; GG738898; EFC39674.1; -; Genomic_DNA.
DR RefSeq; XP_002672418.1; XM_002672372.1.
DR STRING; 5762.D2VUD6; -.
DR EnsemblProtists; EFC39674; EFC39674; NAEGRDRAFT_81257.
DR GeneID; 8858503; -.
DR VEuPathDB; AmoebaDB:NAEGRDRAFT_81257; -.
DR eggNOG; KOG1998; Eukaryota.
DR InParanoid; D2VUD6; -.
DR OrthoDB; 8258at2759; -.
DR Proteomes; UP000006671; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd11684; DHR2_DOCK; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR PANTHER; PTHR45653; DEDICATOR OF CYTOKINESIS; 1.
DR PANTHER; PTHR45653:SF10; MYOBLAST CITY, ISOFORM B; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR PROSITE; PS51651; DOCKER; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000006671}.
FT DOMAIN 1889..2319
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 91..145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 181..211
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 299..333
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 407..429
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 449..487
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1523..1543
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 91..123
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 187..203
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 299..329
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 407..424
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 449..472
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2320 AA; 264430 MW; 7F3E506EF563935F CRC64;
MPPALSTISS FGEIFGGGSL GFFNNNTPKQ LWPQYEHTFG IVIQPFEPPA QYADYCIKLS
LGDLVLIKGE NEGWYKGERF PSMLNLAHPS LKSKSPSGAS SRRNNNNNGL LGSSSLSDSD
PQIILPPPTS PNTLNMMPTS PTGGLQPTNY LSAAIVAAAS STNDNGVGNW TQQHNSMIIT
ASDDKEISKS SSSKRRKNDS NGGDQQQDKL NMTSKGFFPA THVIRFDGSP NNPFSLNYQL
STGIENNPNR QSLVLNQEIT LAYIQQQLQA MGSSLNKIHK LLILKSQAQE LQILLSSNMN
SNNGSPNNPF LSNENNSSGG STPAGTVNSG NGGGIVVPPI TVSSSSNSSL QDEMNNNSII
SNSILQETGL TSPRLYGTTQ PQSLPSNNLF LSNSAFSISD SNLHMNGTGH VSPTFTSPAN
QHQQHRAKSF RRGLMNSFSA TKQKLENYIS KDKSYESPTP SEKSERKPLT PTVDKRQSII
NDSSKNKRAS LNLSGMNLSN VFSASASREE FSNQRTSSLA DNIFSSGGND NDKLLSPKGS
NHDRKRSQSI ASNAAFAIAP KNANIIISNA LIALGNVFPE QIYAQSNYLG ASVEILQNMS
QHYQREIVPF LEDNWFSPFL AVPFCKSMIE TVYEWNLSHF ESLVTQEDNR DRFMRVFEIE
ARMINYLIDY YSYQRREDSE NYKSRMKEIL KSQVSLREEG ASLFSEDVVI KKNGEKLSPL
NTPLFDLYKM YWETIDKEES NLALSILKTK RRSYSRIPEG NSQLAIEIGG CSYYLKVEWR
FSLFDISTKS FLSEDLVIFT SSMHHSRVSV TGPEEVLKIA TNATLRQRQN LYALFKDVSR
AFIEREQMLI LVRAFRVERV KLDTPVNGKT FLDCRIPMAV GVSPKLTKSV VSELAGGVTL
KHEVTFFNFK SNDNLDSFLD QVMNDDQNLE REDIMGIDVS LSMVTGDYHK AYKQYPQLSQ
LPLVPMTRFS SSIISDDIRN DIYINVKNVL NKNVKTLFVE AKMYIKGKDG MTIQCDINRK
QRVYRSAIVR MKNPSWSEIL LVNVNSHQLQ SAIIVFEFYV VNTKKNAYEI SPDFFAYFHV
DDGTRTLTLG NETQIDPLPC YDFTKGFTNI HEFDQNEPIK QKCQKNAKLC LAVNVVSTSI
AINPNLRDFL KWDIMDETNI QSIINNIDFK TVDTTICFRE IMTSFLGIAN KYGKPKTSDS
FEFKESQLLQ KVFEKICILL AQFVDSPETS ISIIEDFKKS LQYSLSHRFI LFYLNKHFDL
IKLDDMTVGT KEKLIRAIKS LNYLLKIAES SLTNFKRKYP QFAEEELRFF QNELSLINVK
LNQLIQKPET ETITIFKSVK NALFDTMTPD FFTTVRDLFN EHRLGRIIEK FSSAIPAEES
YRKLHFFDNI ISSEPFQKGT LSKTLYPIVL EALEGYSECF LEPKSISIMN KIIHLFKTRM
SHDGKSFKST FGLGDLNIST TSEHQTERMT VVSEEETDTA LLSKEHREKM KECATSLIDF
FGLLSMLKEA FDVSLERTEE LEAEYSRERT EQETATQTLD STTRDARTNN SLIAKKFEPE
INQAKRISCD IILTIVNFLD LLTFKGVLDT IFANLNENSQ LAELDTKDLL LDLISIVLSK
KNPLPKNWTQ LNIYQYGTIA NIILMIFLKL KKYITTMEGC SITTIHNLSQ ERSVSTNSPP
AEFNVYRIVK LSQLLVRHLF DAIFSFEPEK MPSYDRKLFL SQNDTRHGIL QVFYDCIWSF
SPLQLQESLL PDLIEKTIKL FKIHVSEIAS VAKNLFFDLL KLEHISRNSL SLCEAATERF
FSEVSGLEGV RRTFISCVES KLKSYKELMV ELLGPEAEDE FANKMDVLME SLHHLLKQIR
DIEAASTNDP NTMNFQNQEK SFKNALKSFK KNSNVQLYFK YLHLLASMQK SRKRYIEAGL
AIFQHAQMLN FNSNIELPLF SDNYPEEPEC TRKIKLYKEV IDLFEKGKDW ERAISLNEEL
RVIYKNKMNY AELSVVHSEE SKLYKKIVTS IREYNKYYFV GFYGKSMSNT NFIFNAHHQK
LADFVNFIKL KFKGATIKRE IPSSFDETKF RTSEQQVIFL APVEPSSQQE INSFMDETTG
EDSFKLLDPT ISPKIQQYHK SHNIKVFKRV KVKREQTEEK SASAGNMDEP KQSMDDQDGS
IFFFAIKKPF PNMYTIQEVR EKKLFKLNSL EVAIYYLELR IHAVQELVVS HKLNESNLLT
ASLDSELTGL IDPRIHGGIY KDVERYLSPE ALENLTEENQ LLIEKYKTRL SQLAYQLKEG
LTQRRKHVSK QNLQMSVYLE KKFKNDLIPL LEKHSINCNI
//
