ID   D2VV18_NAEGR            Unreviewed;       347 AA.
AC   D2VV18;
DT   02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT   02-MAR-2010, sequence version 1.
DT   27-MAR-2024, entry version 47.
DE   SubName: Full=Predicted protein {ECO:0000313|EMBL:EFC39363.1};
GN   ORFNames=NAEGRDRAFT_52487 {ECO:0000313|EMBL:EFC39363.1};
OS   Naegleria gruberi (Amoeba).
OC   Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC   Vahlkampfiidae; Naegleria.
OX   NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN   [1] {ECO:0000313|EMBL:EFC39363.1, ECO:0000313|Proteomes:UP000006671}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NEG-M {ECO:0000313|EMBL:EFC39363.1,
RC   ECO:0000313|Proteomes:UP000006671};
RX   PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA   Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA   Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA   Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA   Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT   "The genome of Naegleria gruberi illuminates early eukaryotic
RT   versatility.";
RL   Cell 140:631-642(2010).
CC   -!- SIMILARITY: Belongs to the serpin family.
CC       {ECO:0000256|RuleBase:RU000411}.
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DR   EMBL; GG738900; EFC39363.1; -; Genomic_DNA.
DR   RefSeq; XP_002672107.1; XM_002672061.1.
DR   AlphaFoldDB; D2VV18; -.
DR   STRING; 5762.D2VV18; -.
DR   EnsemblProtists; EFC39363; EFC39363; NAEGRDRAFT_52487.
DR   GeneID; 8854068; -.
DR   VEuPathDB; AmoebaDB:NAEGRDRAFT_52487; -.
DR   eggNOG; KOG2392; Eukaryota.
DR   InParanoid; D2VV18; -.
DR   OrthoDB; 3218836at2759; -.
DR   Proteomes; UP000006671; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR   CDD; cd00172; serpin; 1.
DR   Gene3D; 2.30.39.10; Alpha-1-antitrypsin, domain 1; 1.
DR   Gene3D; 3.30.497.10; Antithrombin, subunit I, domain 2; 1.
DR   Gene3D; 2.10.310.10; Serpins superfamily; 1.
DR   InterPro; IPR023795; Serpin_CS.
DR   InterPro; IPR023796; Serpin_dom.
DR   InterPro; IPR000215; Serpin_fam.
DR   InterPro; IPR036186; Serpin_sf.
DR   InterPro; IPR042178; Serpin_sf_1.
DR   InterPro; IPR042185; Serpin_sf_2.
DR   PANTHER; PTHR11461:SF211; ACCESSORY GLAND PROTEIN ACP76A-RELATED; 1.
DR   PANTHER; PTHR11461; SERINE PROTEASE INHIBITOR, SERPIN; 1.
DR   Pfam; PF00079; Serpin; 1.
DR   SMART; SM00093; SERPIN; 1.
DR   SUPFAM; SSF56574; Serpins; 1.
DR   PROSITE; PS00284; SERPIN; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000006671}.
FT   DOMAIN          15..343
FT                   /note="Serpin"
FT                   /evidence="ECO:0000259|SMART:SM00093"
SQ   SEQUENCE   347 AA;  40313 MW;  CE657ABCFF13F1A6 CRC64;
     MVRGMFGSEL EEQGLDYFGI IEKDVKPMME QMMKSFNIEN DDDCGTTLSM VNSIFLSDQF
     TLLESYHSLV NQTFNAKVDS CDFVNNQEGE IAKINKFVSD FTKGMIQNIV DCNFIQKTTR
     IVSLNGIYFA AQWKDQFDPS ETKKKPFFTC DGSDSVSIEM MIKKDTRVLY GNDDPDEDEN
     PQYHWIKLPY RSEHSMIIIM PMDKTEENDV FDKWIVEKLE RMYYFSTESI TMDRLSLPKM
     KIKEKVNLND VFKSEPFNMK SMFSENANFE RMIQNDHLPI TDIFHECVIE INEEGTKASA
     ITIKGRGKSA KSKFYFDVNR PFVMLITENC TQQVLFISKI NNLSSSE
//