ID D2VW18_NAEGR Unreviewed; 371 AA.
AC D2VW18;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Predicted protein {ECO:0000313|EMBL:EFC38936.1};
GN ORFNames=NAEGRDRAFT_52704 {ECO:0000313|EMBL:EFC38936.1};
OS Naegleria gruberi (Amoeba).
OC Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC Vahlkampfiidae; Naegleria.
OX NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN [1] {ECO:0000313|EMBL:EFC38936.1, ECO:0000313|Proteomes:UP000006671}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEG-M {ECO:0000313|EMBL:EFC38936.1,
RC ECO:0000313|Proteomes:UP000006671};
RX PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT "The genome of Naegleria gruberi illuminates early eukaryotic
RT versatility.";
RL Cell 140:631-642(2010).
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DR EMBL; GG738903; EFC38936.1; -; Genomic_DNA.
DR RefSeq; XP_002671680.1; XM_002671634.1.
DR AlphaFoldDB; D2VW18; -.
DR STRING; 5762.D2VW18; -.
DR EnsemblProtists; EFC38936; EFC38936; NAEGRDRAFT_52704.
DR GeneID; 8853964; -.
DR VEuPathDB; AmoebaDB:NAEGRDRAFT_52704; -.
DR eggNOG; ENOG502SGQR; Eukaryota.
DR InParanoid; D2VW18; -.
DR OMA; NIHARSQ; -.
DR OrthoDB; 5479060at2759; -.
DR Proteomes; UP000006671; Unassembled WGS sequence.
DR CDD; cd05124; AFK; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR015275; Actin-fragmin_kin_cat_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR037469; Put_AFK.
DR PANTHER; PTHR38737; ACTIN-FRAGMIN KINASE DDB_G0279609-RELATED; 1.
DR PANTHER; PTHR38737:SF1; ACTIN-FRAGMIN KINASE DDB_G0279609-RELATED; 1.
DR Pfam; PF09192; Act-Frag_cataly; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000006671}.
FT DOMAIN 62..317
FT /note="Actin-fragmin kinase catalytic"
FT /evidence="ECO:0000259|Pfam:PF09192"
FT REGION 23..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..49
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 371 AA; 42425 MW; 758B77FA8954182D CRC64;
MRSFEWGISK FYKKMSVPPP PGGIPSMPLV KPVEKTTSQP KSSLQKSSLS LSEAKTHPLD
IPIDWSNIQN VFLSSNQTSG ILFVETQEKD HVVVVKATST IAQEIYGGKI AEFLGLKTPQ
VKLMEYRADF KNPIKKYWAD CKKYLKEFTV KYGMSVEQRK IEKELFRAFF LLMEFIEGAT
SLDDIMSDES IGKSLLENEQ VCEDFGGMIV LDIILNNCDR LPLDLIWNHE GNSSNILFSP
KLQRLVLIDQ AFMAIINEGQ KQTYFKKIES FSKCCSEETL SNNPYLDQVV DYIYNCTGYK
MSDQAKENIH KGILKSIEKL KSINKETLQG FKTEVEMMKT GSDWESTYFN SVLTIDIDFL
YEAIQKMTNI Q
//
