ID   D2VW78_NAEGR            Unreviewed;       933 AA.
AC   D2VW78;
DT   02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT   02-MAR-2010, sequence version 1.
DT   27-MAR-2024, entry version 55.
DE   SubName: Full=TPR domain-containing protein {ECO:0000313|EMBL:EFC38965.1};
GN   ORFNames=NAEGRDRAFT_59390 {ECO:0000313|EMBL:EFC38965.1};
OS   Naegleria gruberi (Amoeba).
OC   Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC   Vahlkampfiidae; Naegleria.
OX   NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN   [1] {ECO:0000313|EMBL:EFC38965.1, ECO:0000313|Proteomes:UP000006671}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NEG-M {ECO:0000313|EMBL:EFC38965.1,
RC   ECO:0000313|Proteomes:UP000006671};
RX   PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA   Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA   Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA   Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA   Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT   "The genome of Naegleria gruberi illuminates early eukaryotic
RT   versatility.";
RL   Cell 140:631-642(2010).
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DR   EMBL; GG738903; EFC38965.1; -; Genomic_DNA.
DR   RefSeq; XP_002671709.1; XM_002671663.1.
DR   AlphaFoldDB; D2VW78; -.
DR   STRING; 5762.D2VW78; -.
DR   EnsemblProtists; EFC38965; EFC38965; NAEGRDRAFT_59390.
DR   GeneID; 8850819; -.
DR   VEuPathDB; AmoebaDB:NAEGRDRAFT_59390; -.
DR   InParanoid; D2VW78; -.
DR   OrthoDB; 34780at2759; -.
DR   Proteomes; UP000006671; Unassembled WGS sequence.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR001440; TPR_1.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR44858; TETRATRICOPEPTIDE REPEAT PROTEIN 6; 1.
DR   PANTHER; PTHR44858:SF1; UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE SPINDLY-RELATED; 1.
DR   Pfam; PF00515; TPR_1; 1.
DR   Pfam; PF13174; TPR_6; 1.
DR   SMART; SM00028; TPR; 6.
DR   SUPFAM; SSF48452; TPR-like; 2.
DR   PROSITE; PS50005; TPR; 3.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000006671};
KW   TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW   ProRule:PRU00339}.
FT   REPEAT          708..741
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          810..843
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          845..878
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          88..140
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          157..215
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        97..114
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        115..135
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        166..190
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   933 AA;  109118 MW;  9A29BE36935A40BC CRC64;
     MFRLVNEETN NESSAETPTT PIVPIVRDGL EVDQILQLPD DDENSSLDLK LFCKLFALDY
     GQQNLLEHAE SNEKQIRKIE EFIFEFTRVE SEEDGSSSSS SSEEEEDEDS DNERNDDDRD
     HSEERRDHSD DEDVITEEQI SNVMQEIKND IKKEQDNRTL NHHHHHQASA SSSQEPSSSN
     STNSNEVNIQ MIDREDSEKD HNDDDDDDND ECSIYKTEPT STKLNILTLS SLNYSPYEHP
     DRFEVRNIMY FSNVTKCKLF KEKQFIGISE IIDTFYKQKK VQLPNFIIFQ ILFAIVEKLY
     EMNEAGLLKR IPNIEQDEHL FYLNRNRHVE KYHVIERLFL DNVEISPKFK TVFHFQDQVG
     YSQFVDVNIN DNFEKTIKNL DMYESDIIFC LGIFILEIMF STTSAHRMIF KILSQPYNEP
     LVCEMMLQEN RNNWCMIRII LSMLRINEPY RLVPKPFYEN PTIEDVNFVP RITLENLIGI
     ELPHVCTILA EDRKIFEYFL APVLSKLTIP YPSHMLNNPL HPSSYKYIAT LENGNVIDLY
     FSFLAGIVLY GSKSMQAADM YLRQSVLHPP VEHDKYVRMI TDLYDMLDNK ENAGKLISEI
     ENICEMNLKS MHADITARFA KAKTSIPFFS FVSYSFLGKA LAEMKKYPLS LYYTEYSMVC
     SKLQQSASLP LFNSSAIFTK AYIVHKYDVF DVSNKLYEQV ISNFKGHSMA HNNRGICLKR
     LKMNEEAIKA YEMSLRIDPS NHLAYNNRAM YFYSDEEHEN SMLYYKMAIR LKPTYQLPIT
     NLGLTLTQLT KYADAIELLT IVLEWSPANV NALITRGFCY MRRTDFEEAL ADYNKLVNEL
     ESEERSTLFN MALCYYHTSR LREAIYYASK IISKNPNDDR ARYYRALFYE KYEKFEESFE
     DVNIFLQLSP ANTAGTILRD RLLVIIKKIT RVC
//