ID D2VWJ2_NAEGR Unreviewed; 2866 AA.
AC D2VWJ2;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=RasGTPase-activating protein {ECO:0000313|EMBL:EFC38849.1};
GN ORFNames=NAEGRDRAFT_73399 {ECO:0000313|EMBL:EFC38849.1};
OS Naegleria gruberi (Amoeba).
OC Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC Vahlkampfiidae; Naegleria.
OX NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN [1] {ECO:0000313|EMBL:EFC38849.1, ECO:0000313|Proteomes:UP000006671}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEG-M {ECO:0000313|EMBL:EFC38849.1,
RC ECO:0000313|Proteomes:UP000006671};
RX PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT "The genome of Naegleria gruberi illuminates early eukaryotic
RT versatility.";
RL Cell 140:631-642(2010).
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DR EMBL; GG738904; EFC38849.1; -; Genomic_DNA.
DR RefSeq; XP_002671593.1; XM_002671547.1.
DR STRING; 5762.D2VWJ2; -.
DR EnsemblProtists; EFC38849; EFC38849; NAEGRDRAFT_73399.
DR GeneID; 8853756; -.
DR VEuPathDB; AmoebaDB:NAEGRDRAFT_73399; -.
DR eggNOG; KOG1826; Eukaryota.
DR InParanoid; D2VWJ2; -.
DR OrthoDB; 1356198at2759; -.
DR Proteomes; UP000006671; Unassembled WGS sequence.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF60; GTPASE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00616; RasGAP; 2.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000006671}.
FT DOMAIN 1321..1529
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 151..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2399..2445
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 152..184
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2409..2426
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2866 AA; 327810 MW; E564927D526DC3EA CRC64;
MEHLLVLTTV ERIGDSLPST PSSQRRKGFN LKGYIKTLNE LIVLPNIDLH KVVQPLVDLY
DNVSKTTINA TLKPSEKRTK LELINKSKLI ILNLLSDYIN FAIENKELVL PNHHLNNLFC
QFDNDDLLLE ERRQEQDEEE DEDLVALVKE QSKNAHQPSQ SASTITESTN EGNESPSIKN
GSLNQISDFE YGHERGRSPS GLGASLDYLN AYKQRKQKKS SSKSQRNFNV KRSAATFTQP
KELDEATALN IIQLVSTRLL LQHDMFYDAT QEEIQKTAVN NYLEQQISYR CMEILFKISV
CKPDTVFKTI VGDSLPTSLN NNCMDISFNT DLQSDKLPFS SSLSHFKLIE YVNWTVGNLE
KLLKAVNENM KGFTKYLEVL TPPLRLAIWN FITNYNNEFV DIIKNPNASI VNTARETFDN
IYKQTGKKQK NKTWPALATL CVLTADDLLK CVKAGNGKKF GGSENMTTFI HKDLLKAMED
KDKSLILPPL IDIYRAVSYA PSDVETAFAV LSLLVEEKFL SIFVPEPTTG KVSKCYSPEE
LNELEMWTFY VTTLYRRSPE KCKKQLMIPI MADGTLEQKQ TVAKVLLFLL TDRSSQFTYN
RKLEVDFKVL ASSLREFFIS TTDQFKGKAR ETGDDNTPTL APSASFRTPK KGFAALLREK
VGGKDSSNSP TGLGSFAGQP NFKMFDTVNT ILHVFCADPR FFLTKSNESD QNINNFAYLA
DFFVLNSDPI VQDQITRLFQ KLFLEQYIKN WGDDLFVGFS TISTRVLSRL SPALFLLNEL
EQLQATKTLL FLLRNITYCA KKFYIANRDT YLLLEHIRTN PDRINTLEVL CSNLLVCLCS
TDKEIWQSTT RCLRDVCDQI EILNNHNIKK LNYNFYRQLA SIDLNGKFYN ERKSQIQLFK
RVETQTPSIL KAFGEVYNRW KELLDQLKSE DSASNITLRD LFPNYTSLLC ALGGVCIQDT
KDEDSSFVLD FLKPEATSAN NVDSYMDDLM KQVISDDVNV RQMVTISVST DLSPSLFTKL
FTAMKASVQE QFGQTFVISQ KNNLLVDQYL HILKTIVENP DTNTDLSLAQ EIDSITDLFA
NYCTHSEFDN KDVLELKKKL CQFLEVLMSK VEYLTFKNIE EQKLRRTIIG HVMEWTTDSV
FKEKTSTGAS VSTPRVASEA PLLENNSQVS TEVKKLYTDL DLLCMKACTS LINGMVIAND
EKGREEYSKY FAFLLRFLEK AKDSTFTATI YKAFSRLLQT NVSFGLEYYM SKVYDNNNTI
RSTFLGLLSE LIKKGLLVEE EEKNKQDRVS ISEYQEIINK LVFTNRKRAL FALFDKCKNP
EKDDLCEAVI RVYQSKGEID KNLLDLFRQS VTREVATTPK SQPETLFRAN STSTKLLKKY
CLRVSNPYLT TVIGGFIDTM CTKPTKFEID PLKAQQRGES VEENVENILE VLQEFIDCLC
DSVQQTPYTF RMYCRYLYEE VGKKFTKPDD DNDEQFDFKY IAVGGFLILR LICPAITSPH
LYGLSGSDIP ADSRRYAIIL TKLVQNLANG IVDSKKEEFM KNFVDIIRLN LNKIQTYFEK
IAAPIVENEE VLRIEETVTE DELKEAYEVL YRFFYNYADT LREELSSLYD DIEDEEKEVL
EEVDINEKPS SKQNGKSLND LLEKAIEQFG KPAEEEKTGR RLSVKLSKDD EFSNPLLKEL
LRKNEKKDTS KIAEMKFFSI SEHKNAKNQR IVYFIPYNLD LTRFSLDLYL YYVLKSMETI
WKEPYIIVVD STFLTKKFDI RLSVFIQLSK HIPQGAKKNL QEIYLVNPNT FFNKTTKKLV
SMLSHNRWKV ITTSSLPAVT DQKSKTPTSK DPLELVKPEH SMLPSLTQQL YEKSEIIYNT
EVVLASHTTD CEIRLFDQYM FIVIKGEKFI NNKVPADCLE HVNVTKIANI AVKKSLFGKS
SKATKDFVVK YIDDEDAEAA YNFRAQTIEE RDQIMQGIRN YVERKSRGTK TGKSLEREFK
RLKLQDVPGQ LLAISFFNLD SKHTPIRASA YSLLASIFEQ VKISSHGLIL ESDAAYVPRN
TENTVLRISE YVARNKPELT LEFICEALNA FKTIQGNKSK LKFASFILPW LDNLSRFEIS
TSVDEVDEKT ETIKNWFENF TKLCIANEEI YPKLQNVWKH VCKLSLPLIR IAIESVIKQG
TTSEMLMNGE QSIIGDILGT ILLHSPLQWN VAQFIINKIV EPLMTEELNI DLLNKATVKE
LVKSKDILGK IPVYMSYLLM LSFNSQINLL ENLPYVLFII SLFLGVGSDT YLRSIVYGIC
CNCVHSLVLE LPACEQFEHV RAKLQKLHLR VLEKDIKSSF MGGEHEPQPF ASYSDFVNKV
SQGKVTFDET TMYKYEDIMR YFKEIIECFD FSYDSLIQAR GKTLKSQFGS TIITSSKATH
SVIEESSENS KDMDEDGTEN DMTEGEVDDE HNGSNPSTST SDIVKSGSDT IKSVWLKIFT
NLCKDTMKTA NLLLFPKSLI SFSIISTSEQ SYDMIPFVLN FIGKRGVETL SENELMLSVL
LSINQFCINM VVEKDRIETL RKIIIFGFFL LTIANTKIYS AVTKLLSTVF AILFEARDIH
DGFLSIGDYF NQVFRSDYSK YLSITKEFEE TVGLSFGQHF SFTVSLLLMK GLAIDDSTIR
KATISLLKQI LSISYKLKFE PQNQLGFIAA LIPFDKQYNS VLYSEQLYSE SMFTKETVFL
FQKYLFSITA SNIDLDSCAS VYRSLARGFE AIPDTFADVF QDHHSMSQVI KVYTSSQDDT
IIEHSLNLFK IMSNNAKSKK LQVKEPFADY GFKGFRDQTT FQTTKDDLKK KCQKTLITFL
TENFNEQEYP SMDSVIISKT GMKKSFLKAA SSSPVVRQAS GTNFKK
//
