ID D2VXK6_NAEGR Unreviewed; 389 AA.
AC D2VXK6;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Predicted protein {ECO:0000313|EMBL:EFC38456.1};
GN ORFNames=NAEGRDRAFT_73782 {ECO:0000313|EMBL:EFC38456.1};
OS Naegleria gruberi (Amoeba).
OC Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC Vahlkampfiidae; Naegleria.
OX NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN [1] {ECO:0000313|EMBL:EFC38456.1, ECO:0000313|Proteomes:UP000006671}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEG-M {ECO:0000313|EMBL:EFC38456.1,
RC ECO:0000313|Proteomes:UP000006671};
RX PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT "The genome of Naegleria gruberi illuminates early eukaryotic
RT versatility.";
RL Cell 140:631-642(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the FNT transporter (TC 2.A.44) family.
CC {ECO:0000256|ARBA:ARBA00006470}.
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DR EMBL; GG738907; EFC38456.1; -; Genomic_DNA.
DR RefSeq; XP_002671200.1; XM_002671154.1.
DR AlphaFoldDB; D2VXK6; -.
DR STRING; 5762.D2VXK6; -.
DR EnsemblProtists; EFC38456; EFC38456; NAEGRDRAFT_73782.
DR GeneID; 8858300; -.
DR VEuPathDB; AmoebaDB:NAEGRDRAFT_73782; -.
DR eggNOG; ENOG502S3A5; Eukaryota.
DR InParanoid; D2VXK6; -.
DR OMA; WFVNARQ; -.
DR OrthoDB; 22085at2759; -.
DR Proteomes; UP000006671; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1080.10; Glycerol uptake facilitator protein; 1.
DR InterPro; IPR023271; Aquaporin-like.
DR InterPro; IPR000292; For/NO2_transpt.
DR InterPro; IPR024002; For/NO2_transpt_CS.
DR PANTHER; PTHR30520; FORMATE TRANSPORTER-RELATED; 1.
DR PANTHER; PTHR30520:SF6; FORMATE_NITRATE FAMILY TRANSPORTER (EUROFUNG); 1.
DR Pfam; PF01226; Form_Nir_trans; 1.
DR PROSITE; PS01005; FORMATE_NITRITE_TP_1; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006671};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 107..129
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 149..178
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 199..219
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 244..264
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 276..300
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 320..342
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..45
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..67
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 389 AA; 43437 MW; 92BA4A7A1D66E9B1 CRC64;
MTSTICEEET NQTNVEQQLS TSSSINNTPL SDTVETNQGA NIGETKKMGE TNHANKRKSQ
NQHKREETPI IYKVKTPEII LFNSPKMVLE RMKVDGIRKS KLTVDQIIIL SLFAGLFIGL
ACAMAILIGG NVPDLEEKNP GLQKLLSGAV FPIGLILIAM TGSELFTGNV LVLLVALFSR
KWRAKKFLLQ YTQFSKNLFV SYLFNCLGAF LFAYFFVYLP QPCCSAYWIK YIQNMSVAKT
TKTFGNLVLL AIICNMLVTV SVFCCNAATT LGGKFLGIWF PLMTFVCLGF EHSIANAFYI
PLGMLYGANV TGYDFLIGNL LPVTIGNIIG GAIINGCLLY YVHDFRVRHH RAIFNFAEKI
WEKIKKRKEN TESNTSSSIE LSESKENMV
//
