ID D2VYI3_NAEGR Unreviewed; 1405 AA.
AC D2VYI3;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Predicted protein {ECO:0000313|EMBL:EFC38115.1};
GN ORFNames=NAEGRDRAFT_74131 {ECO:0000313|EMBL:EFC38115.1};
OS Naegleria gruberi (Amoeba).
OC Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC Vahlkampfiidae; Naegleria.
OX NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN [1] {ECO:0000313|EMBL:EFC38115.1, ECO:0000313|Proteomes:UP000006671}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEG-M {ECO:0000313|EMBL:EFC38115.1,
RC ECO:0000313|Proteomes:UP000006671};
RX PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT "The genome of Naegleria gruberi illuminates early eukaryotic
RT versatility.";
RL Cell 140:631-642(2010).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; GG738911; EFC38115.1; -; Genomic_DNA.
DR RefSeq; XP_002670859.1; XM_002670813.1.
DR STRING; 5762.D2VYI3; -.
DR EnsemblProtists; EFC38115; EFC38115; NAEGRDRAFT_74131.
DR GeneID; 8858010; -.
DR VEuPathDB; AmoebaDB:NAEGRDRAFT_74131; -.
DR eggNOG; KOG1225; Eukaryota.
DR InParanoid; D2VYI3; -.
DR OrthoDB; 5475408at2759; -.
DR Proteomes; UP000006671; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR013111; EGF_extracell.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR PANTHER; PTHR24033; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24033:SF151; PROTEIN EYES SHUT; 1.
DR Pfam; PF07974; EGF_2; 2.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF00615; RGS; 1.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR PROSITE; PS00022; EGF_1; 3.
DR PROSITE; PS01186; EGF_2; 3.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50132; RGS; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006671};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 886..909
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 921..940
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 966..987
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1026..1049
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1061..1089
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1153..1175
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1195..1220
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..28
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 106..145
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1243..1386
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
FT DISULFID 18..27
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 135..144
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1405 AA; 155964 MW; C59F48CAACE9ACDA CRC64;
MNVCSGHGSC PVPNNCTCQP GYYGYQCEAH QCYGTLFNNS NVCSTHGQCL SPNNCFCEAG
YYGPECSEHD CFGVHKNSSN VCFKHGTCLS PNNCSCQEGY FSFDCSNHNC FGILFNDTNV
CSSHGSCFVP DNCTCQPGYY GQTCELHNCF GTLFNESSVC SGKGQCVSPN YCSCVEGFTN
KDCSVNISPF QINITKYEEV VYLEFDNKTV SVEIQLIDQV LSQSPNISYT WSCVECDGQN
VVFYVESNRL LINSTLTDVT QAGNYTFIAN ASIANIQPFQ SRKSNLQQFK LVVKYELNEP
TLGSFGLPSV LVSGTQDQTI STVINSITLN TTTIRYFLGC GKNCSTLVSY EWKVSAGVFS
YKRSGSVLAK YDNTNLLSFS PSVPIQASIP SNYLNETVLF TFTVINSKQQ NISSSVQIQI
ISSASPPTRV SNLVSVSPIS GISMNDKFTI QVSEWVATSP ELLPLKYAFG YYDKSKAESV
RLTEYSLNTT FSSYLPYIRS ESSSTKSRSI LETTETISLV VFVKDALGNV ETEASANVTV
SPFNGTQEQY IEVVKSLSGE SLLGASVDQT FTTSSASSSL VSALISNVVI DPKNPSSSLS
SLETLTSNNE TLTADTVSLV INKVDSFVSN LTDIYLSELA LYGYVKSSLS SADISKTIQV
ISNCFSTSYD SEKTKSTASL VTVLIYYGTI PTVVSSTSTD LPTSSYKSSL INITVSSFNV
PTPTSNLQSV SDTESKVSMN LTSVMSKYGT YSMTCGATMI VYSKNTNYDA SVSNMTLSSS
VTDFKFMKKT DVLVLDNLDS PLILSFNAAT IPSSIISNST VTNSTYHCKY WDEKLKMWSS
YGCSLHRVSS NSIECACSHT TMFTTFLESK TTTFTVQLKD QVSSLYYAQI SFGIIYLIAA
SAILIGLIVL RKSQPVSSRL LTPYVGLIAL IVECTLIYIV QRSVLVDQLN SANSQMWESG
DAAANIIANI VMIIVNTLNL TAIFCYVMQV FRFQFMKLLY KKLSDNRTQA QSTTILKALK
YATSQVLFYS LIGIFAAVNV VYWVIWVILR RTGVLDSLQY TYIVSVSYTV CILTFGVIIT
AVAILDMILS SKKEVDQKKN RRRAVNFSQP TSTFSLDNAE NINEKKKLNK NILLTAFHWF
TSMDGPLYFR MEMFIYIISF ILLILNQVIG LSSLSYRFES LAMFKLALTF DSISFIFEVL
YVISYILVFG GYALIVALVY KFRQRRTKKE EQKKQNDEIM NQELYNTLES EEGYELFANF
CEKEFSSENL FLFSDIKAST DVVSGENLGG LVFFADRIYQ KYIKTGAEME VNIPSKSRTA
FIQLYEKCKK LDESNCELLD LNSLSKLGIE NSMVKDCFEL MMRQVVMNLG DTFSRFVFTP
DYVNFKAVRD VQMQIIEKAN VVYGI
//
