UniProt: D2VYJ0

Database: UniProt
Entry: D2VYJ0_NAEGR

LinkDB:  D2VYJ0_NAEGR 
Original site:  D2VYJ0_NAEGR

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Ontology (4)   
   GO (4)   
Gene (2)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (12)   
   InterPro (5)   
   Pfam (2)   
   PROSITE (3)   
   SMART (2)   
Literature (1)   
   PubMed (1)   
All databases (21)   

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ID   D2VYJ0_NAEGR            Unreviewed;      1710 AA.
AC   D2VYJ0;
DT   02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT   02-MAR-2010, sequence version 1.
DT   27-MAR-2024, entry version 62.
DE   SubName: Full=Predicted protein {ECO:0000313|EMBL:EFC38121.1};
GN   ORFNames=NAEGRDRAFT_74138 {ECO:0000313|EMBL:EFC38121.1};
OS   Naegleria gruberi (Amoeba).
OC   Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC   Vahlkampfiidae; Naegleria.
OX   NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN   [1] {ECO:0000313|EMBL:EFC38121.1, ECO:0000313|Proteomes:UP000006671}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NEG-M {ECO:0000313|EMBL:EFC38121.1,
RC   ECO:0000313|Proteomes:UP000006671};
RX   PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA   Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA   Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA   Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA   Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT   "The genome of Naegleria gruberi illuminates early eukaryotic
RT   versatility.";
RL   Cell 140:631-642(2010).
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC       family. {ECO:0000256|RuleBase:RU000405}.
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DR   EMBL; GG738911; EFC38121.1; -; Genomic_DNA.
DR   RefSeq; XP_002670865.1; XM_002670819.1.
DR   EnsemblProtists; EFC38121; EFC38121; NAEGRDRAFT_74138.
DR   GeneID; 8858016; -.
DR   VEuPathDB; AmoebaDB:NAEGRDRAFT_74138; -.
DR   eggNOG; KOG1023; Eukaryota.
DR   InParanoid; D2VYJ0; -.
DR   OMA; ETITYAY; -.
DR   OrthoDB; 5478931at2759; -.
DR   Proteomes; UP000006671; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016849; F:phosphorus-oxygen lyase activity; IEA:InterPro.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   CDD; cd00130; PAS; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR018297; A/G_cyclase_CS.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   NCBIfam; TIGR00229; sensory_box; 1.
DR   PANTHER; PTHR11920:SF335; GUANYLATE CYCLASE 32E; 1.
DR   PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   Pfam; PF13426; PAS_9; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SMART; SM00091; PAS; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR   PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR   PROSITE; PS50112; PAS; 1.
PE   3: Inferred from homology;
KW   Lyase {ECO:0000256|RuleBase:RU000405};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006671};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        56..76
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        111..136
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        148..168
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        223..247
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        259..283
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        289..307
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        319..341
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        353..375
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        732..754
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        945..966
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1020..1040
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1255..1275
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1330..1403
FT                   /note="PAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50112"
FT   DOMAIN          1494..1628
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
SQ   SEQUENCE   1710 AA;  192819 MW;  88436FC5862E49FA CRC64;
     MRSSIAGASF IGSDSSQNSE SIVSESASSL QVKVRTEFLS FVFTAQNTSR RHGTRTFVMT
     LTLYILLFWS FIWMPLLSPH HFNFGVWGSW IFTVLNYTTS LSLDLIPYDG AIALASISMF
     FVLFALGAFA LTIRAVRSTS KFIPYVKYVF HISLFALLIL SAPMTYIFTS FVDCDYGYNT
     NNLVQQQGST SVAVGSLLSN STTTTTSYLN RFDSVTCFET RNIVMMALSL IFIVLLQVEA
     LLTVIMLPNS HPLSTTPMIG DSAILPLLGV ICNILGMLVH FLIPANYAFI RSIVHLVCSF
     ILLVLLFKIF PMMRRFENSI VAGVISARIG ASIGGLVTSL ANPTNDNVMG VGLSMMTLAL
     VVLLGILGGV IAEIYSRIIV KKLRKKFITA IQDKNIEREA LNIYQQLEDD GNLSKMDMYM
     RFTMGVEVML KDEEENADLM FIISFIRAIS SQKGFSDQNI LNSSACIAAY FMGEELNAST
     FALALLKKAI KQRPNLYMRF LLGQRLKEVE TSTTEGIRGQ KNAIDLKATF SKIEKSMLEI
     TSLHRHFWKE QMQEIVNYEK IESIASRNAV LIEECDNMFN SLLSLYYNDK TVLRMYANYL
     ENIKFNKDLA SEYFNEAMTL EEDEGNFQKR GAAFKAKLAR KNRVHPDSNS VGTAETVDNS
     RKLIQASVNA INFTVENPQS FSQMNYETMS SIEDSFDNFN GIENTVSGEQ KREMVFRNAL
     SVPAPRNIQM TIFFLFAGLG FAFLIAGIVI ALNFSDVVTL NVINVIDACS PIAALSNMLV
     TVRAYQSTVN LMNSTSSSIP KTMTSEMFLS PKLLKQNIVK LRQILVNLQQ KAYDAKFNPS
     VYSHYHEFYY PFYVPKMQSD ATMETKFYNE TMAENVTITD ITNVLVKLSD QMVNSGDDQL
     MNSLNSYGFM LMYRNQETIT YAYQKFCRVF TDSAKEDALR INDTFTIFTS VVLAFYVVYA
     TIYLLYSRFE LSTMKQQIKL IHTHVSKNEV GKLFHDLGKK VGDEVSIHIP KTSILKPKNI
     FIIIGIFVMI AVSVSLGIFL KETLGNSKYS FESYITMEDG FDAMAFLQRL SFNVAEQFYH
     SSTNMLNNYG LDEIPILAES DIKVLRTNFD YVVFKLRYFW NLCMYGSAVK AYETLVVGMF
     PETDHMIRGD LNCTIESVSS IYNAMVIPKG YKPDNYTQCD FGIDYMVQDT ILKSSRIIED
     LVATTKTSNY QDLLVILQEF YAVAFLANTA SFKLIDFSLI FAVKSSTPMV TQITALAIVG
     FTVNLIGCVI MYYFLRIHWK NVFSLRSLFN YLSIETFENN EQLRNYALYH SLSDGALSRL
     FVKKRNVGGE DAKVRNILNA AVDGVILCSH RGDIEIFNPA AQRMFGNQQE DVIGKLLFTL
     LCPQHHDEIR KAVDSMKQTV TEFDPKGESF DVECIRKNQT TFPAKMNIFV TLFEKKPIIT
     CFIKDITSEK KHNALLAEEK KNSETLLLNI LPGAVAAKLK NGTSLIAEKF ADITCFFSDM
     VGFTSLSSKL APNELVQMLN QIVMGFDDLT DRYHLEKIKT IGDAYFAAGG LHDLNAQSDH
     PERVLKFAID TFGVIRSFNS NFRKGRFEEQ VNIRIGINTG PVVAGVIGRK KFAYDLWGDS
     INTASRMESN SKPGRIQVSR STYERVYDLG FSFEERMIEV KGKGMTQTYL LSAKHHESAV
     LTSEELNANA DNFIGEDVSS EIQPEDETLH
//

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