ID D2VYJ0_NAEGR Unreviewed; 1710 AA.
AC D2VYJ0;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Predicted protein {ECO:0000313|EMBL:EFC38121.1};
GN ORFNames=NAEGRDRAFT_74138 {ECO:0000313|EMBL:EFC38121.1};
OS Naegleria gruberi (Amoeba).
OC Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC Vahlkampfiidae; Naegleria.
OX NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN [1] {ECO:0000313|EMBL:EFC38121.1, ECO:0000313|Proteomes:UP000006671}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEG-M {ECO:0000313|EMBL:EFC38121.1,
RC ECO:0000313|Proteomes:UP000006671};
RX PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT "The genome of Naegleria gruberi illuminates early eukaryotic
RT versatility.";
RL Cell 140:631-642(2010).
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
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DR EMBL; GG738911; EFC38121.1; -; Genomic_DNA.
DR RefSeq; XP_002670865.1; XM_002670819.1.
DR EnsemblProtists; EFC38121; EFC38121; NAEGRDRAFT_74138.
DR GeneID; 8858016; -.
DR VEuPathDB; AmoebaDB:NAEGRDRAFT_74138; -.
DR eggNOG; KOG1023; Eukaryota.
DR InParanoid; D2VYJ0; -.
DR OMA; ETITYAY; -.
DR OrthoDB; 5478931at2759; -.
DR Proteomes; UP000006671; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016849; F:phosphorus-oxygen lyase activity; IEA:InterPro.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR11920:SF335; GUANYLATE CYCLASE 32E; 1.
DR PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF13426; PAS_9; 1.
DR SMART; SM00044; CYCc; 1.
DR SMART; SM00091; PAS; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS50112; PAS; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|RuleBase:RU000405};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006671};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 56..76
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 111..136
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 148..168
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 223..247
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 259..283
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 289..307
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 319..341
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 353..375
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 732..754
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 945..966
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1020..1040
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1255..1275
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1330..1403
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 1494..1628
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
SQ SEQUENCE 1710 AA; 192819 MW; 88436FC5862E49FA CRC64;
MRSSIAGASF IGSDSSQNSE SIVSESASSL QVKVRTEFLS FVFTAQNTSR RHGTRTFVMT
LTLYILLFWS FIWMPLLSPH HFNFGVWGSW IFTVLNYTTS LSLDLIPYDG AIALASISMF
FVLFALGAFA LTIRAVRSTS KFIPYVKYVF HISLFALLIL SAPMTYIFTS FVDCDYGYNT
NNLVQQQGST SVAVGSLLSN STTTTTSYLN RFDSVTCFET RNIVMMALSL IFIVLLQVEA
LLTVIMLPNS HPLSTTPMIG DSAILPLLGV ICNILGMLVH FLIPANYAFI RSIVHLVCSF
ILLVLLFKIF PMMRRFENSI VAGVISARIG ASIGGLVTSL ANPTNDNVMG VGLSMMTLAL
VVLLGILGGV IAEIYSRIIV KKLRKKFITA IQDKNIEREA LNIYQQLEDD GNLSKMDMYM
RFTMGVEVML KDEEENADLM FIISFIRAIS SQKGFSDQNI LNSSACIAAY FMGEELNAST
FALALLKKAI KQRPNLYMRF LLGQRLKEVE TSTTEGIRGQ KNAIDLKATF SKIEKSMLEI
TSLHRHFWKE QMQEIVNYEK IESIASRNAV LIEECDNMFN SLLSLYYNDK TVLRMYANYL
ENIKFNKDLA SEYFNEAMTL EEDEGNFQKR GAAFKAKLAR KNRVHPDSNS VGTAETVDNS
RKLIQASVNA INFTVENPQS FSQMNYETMS SIEDSFDNFN GIENTVSGEQ KREMVFRNAL
SVPAPRNIQM TIFFLFAGLG FAFLIAGIVI ALNFSDVVTL NVINVIDACS PIAALSNMLV
TVRAYQSTVN LMNSTSSSIP KTMTSEMFLS PKLLKQNIVK LRQILVNLQQ KAYDAKFNPS
VYSHYHEFYY PFYVPKMQSD ATMETKFYNE TMAENVTITD ITNVLVKLSD QMVNSGDDQL
MNSLNSYGFM LMYRNQETIT YAYQKFCRVF TDSAKEDALR INDTFTIFTS VVLAFYVVYA
TIYLLYSRFE LSTMKQQIKL IHTHVSKNEV GKLFHDLGKK VGDEVSIHIP KTSILKPKNI
FIIIGIFVMI AVSVSLGIFL KETLGNSKYS FESYITMEDG FDAMAFLQRL SFNVAEQFYH
SSTNMLNNYG LDEIPILAES DIKVLRTNFD YVVFKLRYFW NLCMYGSAVK AYETLVVGMF
PETDHMIRGD LNCTIESVSS IYNAMVIPKG YKPDNYTQCD FGIDYMVQDT ILKSSRIIED
LVATTKTSNY QDLLVILQEF YAVAFLANTA SFKLIDFSLI FAVKSSTPMV TQITALAIVG
FTVNLIGCVI MYYFLRIHWK NVFSLRSLFN YLSIETFENN EQLRNYALYH SLSDGALSRL
FVKKRNVGGE DAKVRNILNA AVDGVILCSH RGDIEIFNPA AQRMFGNQQE DVIGKLLFTL
LCPQHHDEIR KAVDSMKQTV TEFDPKGESF DVECIRKNQT TFPAKMNIFV TLFEKKPIIT
CFIKDITSEK KHNALLAEEK KNSETLLLNI LPGAVAAKLK NGTSLIAEKF ADITCFFSDM
VGFTSLSSKL APNELVQMLN QIVMGFDDLT DRYHLEKIKT IGDAYFAAGG LHDLNAQSDH
PERVLKFAID TFGVIRSFNS NFRKGRFEEQ VNIRIGINTG PVVAGVIGRK KFAYDLWGDS
INTASRMESN SKPGRIQVSR STYERVYDLG FSFEERMIEV KGKGMTQTYL LSAKHHESAV
LTSEELNANA DNFIGEDVSS EIQPEDETLH
//