ID D2VYZ6_NAEGR Unreviewed; 605 AA.
AC D2VYZ6;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Predicted protein {ECO:0000313|EMBL:EFC37994.1};
GN ORFNames=NAEGRDRAFT_59633 {ECO:0000313|EMBL:EFC37994.1};
OS Naegleria gruberi (Amoeba).
OC Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC Vahlkampfiidae; Naegleria.
OX NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN [1] {ECO:0000313|EMBL:EFC37994.1, ECO:0000313|Proteomes:UP000006671}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEG-M {ECO:0000313|EMBL:EFC37994.1,
RC ECO:0000313|Proteomes:UP000006671};
RX PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT "The genome of Naegleria gruberi illuminates early eukaryotic
RT versatility.";
RL Cell 140:631-642(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; GG738912; EFC37994.1; -; Genomic_DNA.
DR RefSeq; XP_002670738.1; XM_002670692.1.
DR AlphaFoldDB; D2VYZ6; -.
DR STRING; 5762.D2VYZ6; -.
DR EnsemblProtists; EFC37994; EFC37994; NAEGRDRAFT_59633.
DR GeneID; 8857938; -.
DR VEuPathDB; AmoebaDB:NAEGRDRAFT_59633; -.
DR eggNOG; ENOG502QRGH; Eukaryota.
DR InParanoid; D2VYZ6; -.
DR OMA; PPVTHDM; -.
DR OrthoDB; 1561at2759; -.
DR UniPathway; UPA00753; -.
DR Proteomes; UP000006671; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006656; P:phosphatidylcholine biosynthetic process; IEA:UniProtKB-UniPathway.
DR InterPro; IPR007318; Phopholipid_MeTrfase.
DR PANTHER; PTHR32138; PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE; 1.
DR PANTHER; PTHR32138:SF0; PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE; 1.
DR Pfam; PF04191; PEMT; 2.
PE 4: Predicted;
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phospholipid biosynthesis {ECO:0000256|ARBA:ARBA00023209};
KW Phospholipid metabolism {ECO:0000256|ARBA:ARBA00023264};
KW Reference proteome {ECO:0000313|Proteomes:UP000006671};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 66..85
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 91..110
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 168..189
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 195..216
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 274..293
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 332..359
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 409..431
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 451..469
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 605 AA; 69169 MW; 0C6792DD8B7D35BF CRC64;
MSTGSPSSPS SPQKSSPSND GDKKSVNKEE EAIGICTTTK ERFNVPLTYD CTDVFVTPQK
WTEWPVIIEL LLIFFYSATY LLGILPKWFF LVNYIFWRLA YNCGLGYILS TQSNGKHFTK
LVQNLIKTHK PMLESNLSLR GKNGVVKHEK YRIDDYPLDF TAWMVYRAVV DVILSSDLAG
YIVFCVAYFE LPTTFGLYEF ISYGIGISLC LFNLWAKSDA HRVLGDYAWY WGDFFFLLDK
NLVFDGIFQM FPHPMYSVGY SFYYGVSIMS RSHTVLVVSF CAHMLQLIFL VFVENPHIEK
IYGGMSSETN QTSEREPIFF KNLEPFKNPD DLFLVVIICY AMFTSLTASF TTAVGHAVLW
RLIHHVGMGY ILYGQAKNQA FTKRFTKLGG TSQQAFTFFK KLYNFSLTIN HVIMVTLTAK
IFITTFIWSG FVAADGASDY HFEGFSQLLS WQYATQLVAG IILILLNIYQ STSTHEVLGD
HGWFYGDFFY TETNQNKQPS YTGIYRYLNN PEIVLGYCAY FGLALISKSY AVLGLAILSQ
FATYLFVKFV EKPHMDKIYG AKNLREKGGI EMELSRVTSH PKIAALNERL DENISKVKKL
LLKQD
//
