ID   D2VZ52_NAEGR            Unreviewed;       887 AA.
AC   D2VZ52;
DT   02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT   02-MAR-2010, sequence version 1.
DT   27-MAR-2024, entry version 46.
DE   SubName: Full=Silent information regulator family protein {ECO:0000313|EMBL:EFC37931.1};
GN   ORFNames=NAEGRDRAFT_59649 {ECO:0000313|EMBL:EFC37931.1};
OS   Naegleria gruberi (Amoeba).
OC   Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC   Vahlkampfiidae; Naegleria.
OX   NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN   [1] {ECO:0000313|EMBL:EFC37931.1, ECO:0000313|Proteomes:UP000006671}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NEG-M {ECO:0000313|EMBL:EFC37931.1,
RC   ECO:0000313|Proteomes:UP000006671};
RX   PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA   Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA   Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA   Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA   Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT   "The genome of Naegleria gruberi illuminates early eukaryotic
RT   versatility.";
RL   Cell 140:631-642(2010).
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DR   EMBL; GG738913; EFC37931.1; -; Genomic_DNA.
DR   RefSeq; XP_002670675.1; XM_002670629.1.
DR   AlphaFoldDB; D2VZ52; -.
DR   STRING; 5762.D2VZ52; -.
DR   EnsemblProtists; EFC37931; EFC37931; NAEGRDRAFT_59649.
DR   GeneID; 8863404; -.
DR   VEuPathDB; AmoebaDB:NAEGRDRAFT_59649; -.
DR   eggNOG; KOG2684; Eukaryota.
DR   InParanoid; D2VZ52; -.
DR   OrthoDB; 5484826at2759; -.
DR   Proteomes; UP000006671; Unassembled WGS sequence.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   Gene3D; 3.30.1600.10; SIR2/SIRT2 'Small Domain; 1.
DR   Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR   InterPro; IPR003000; Sirtuin.
DR   InterPro; IPR026591; Sirtuin_cat_small_dom_sf.
DR   PANTHER; PTHR11085:SF12; NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR11085; NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED; 1.
DR   Pfam; PF02146; SIR2; 1.
DR   SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR   SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000006671}.
FT   REGION          176..195
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   887 AA;  101957 MW;  0B3B78B0B838A30D CRC64;
     MAQDECCVVF DLIDTPEANS TLQNYLKGKF KEPTMVEFSG RFAIERVIDL GCCSFSFVIV
     REYNLLLVVV VNGVKFLDLD SYNVVYSLLF GNELDFVNLE RTPSELNIIL VGSEKMLYKY
     DLKKILDEKL TNESLYTALI WEQQTTCSLL VGFDSMDNQL FVVDYNDTIQ IFDSKSGKRV
     SSSGGESSQK KIKKNADQKV NEDCVKVNLW NFNEREELLN SMVKLKRHWE KRKLSTFKYQ
     FNCVDSIDGS IEVEGIIGDC LFTNPYDVKI SHTHQAIIVL DNILERLLIF DVNSLEFCSC
     VETEREGDSL ALELEYCDSR TDALYIAYGS YGKLIKYDLE KLCAPDANIR ECQVWVQDNF
     DSPYSTAVSY GSKSFNEKYH FSENTLYVCD RESDCIAILE ASTGEPLTMI EFSFNGILQS
     VDFLNDRHLV VSLFDKILIL EKDRRRDWRC IKSFDNTECL YLTCDRDSNK ILCSTALGLL
     IIDVERSVKE IKVLGMKAFS STRTRTTFKE ELEATTTIEE ENNEEGYYTT TSQKRIQKQS
     LTDQLKRKIQ EEKSSSSTLL EKARNLLKEK EKIIVVTGPT ITTQAVLPKD VFEKATIKYY
     QQTNAVHSSH VFGDLHILYN IEHKAEKVVE GIEYASVEEI QNFQLEQIKT RKQDMKQDLE
     VNEGSTDDLF NFDRFVENPR PLLNYLEKLT YGWSRIYKKP SKVLKFLMSL DEQEKIQRIY
     SESIEKLPFE DEKVINCLGT LDSFTCSTCE KTFDFKTGAA MFPNKDVPTN KKGKCEQMAK
     KDCSLKPNIL MLGESYPSSI SDNKRSDFEN CDLVVVLGVP LSRFPMNKLL NDIKKNTPIL
     FIIPDIFLQL YNDSNLPPVL KDWIQNKSSN TIVLPLSETM DSFIESL
//