ID D2VZN3_NAEGR Unreviewed; 4270 AA.
AC D2VZN3;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=Dynein heavy chain {ECO:0008006|Google:ProtNLM};
GN ORFNames=NAEGRDRAFT_81845 {ECO:0000313|EMBL:EFC37691.1};
OS Naegleria gruberi (Amoeba).
OC Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC Vahlkampfiidae; Naegleria.
OX NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN [1] {ECO:0000313|EMBL:EFC37691.1, ECO:0000313|Proteomes:UP000006671}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEG-M {ECO:0000313|EMBL:EFC37691.1,
RC ECO:0000313|Proteomes:UP000006671};
RX PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT "The genome of Naegleria gruberi illuminates early eukaryotic
RT versatility.";
RL Cell 140:631-642(2010).
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DR EMBL; GG738915; EFC37691.1; -; Genomic_DNA.
DR RefSeq; XP_002670435.1; XM_002670389.1.
DR STRING; 5762.D2VZN3; -.
DR EnsemblProtists; EFC37691; EFC37691; NAEGRDRAFT_81845.
DR GeneID; 8857644; -.
DR VEuPathDB; AmoebaDB:NAEGRDRAFT_81845; -.
DR eggNOG; KOG3595; Eukaryota.
DR InParanoid; D2VZN3; -.
DR OrthoDB; 166463at2759; -.
DR Proteomes; UP000006671; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF1; DYNEIN HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000006671}.
FT DOMAIN 950..1365
FT /note="Dynein heavy chain linker"
FT /evidence="ECO:0000259|Pfam:PF08393"
FT DOMAIN 1510..1836
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 2004..2137
FT /note="Dynein heavy chain AAA 5 extension"
FT /evidence="ECO:0000259|Pfam:PF17852"
FT DOMAIN 2378..2456
FT /note="Dynein heavy chain 3 AAA+ lid"
FT /evidence="ECO:0000259|Pfam:PF17857"
FT DOMAIN 2531..2807
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 2822..3161
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 3190..3395
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 3646..3759
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 3794..3934
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
FT DOMAIN 3941..4267
FT /note="Dynein heavy chain C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18199"
FT REGION 67..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 876..936
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2850..2895
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3046..3108
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3355..3400
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 80..112
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4270 AA; 493451 MW; 3CA2EF3CD3F84B9B CRC64;
MRETKRSPSA ASALDESATV QGLSRFKHFH SASAPESLGV DKLEYKPKNT YNVRPKTTIQ
PQKLKIPKEL QQFNHLDPSR NTSTKKRETS TTTTKRASAQ EKSRKTLEER PPKQAKYTTS
VSRLSELNSL NVSARIGALK QMDVEEGTID VASYPRLLII NKEFSEEEKD IIMSGQEIES
KSKFLPLELF DDEEIFEKFT IEDLLSNSYI VQSKFYTGAK SAYEKSYKWA RCRVLEYNPD
ERSFLIEWLD SPNTTGYEIT TTDENNDSPT TTNGRKQKWV KRLNLLVHGD ETFELRIRFA
QMRRKKFEEK MFYYLQIDKT ITDDLIDITP FEKQIYEKIL KLVANESQFL SRHVPVIEKY
VDEAKEHYKI SMKEAIFLYY LNSREEYEKY EKYLWCKEEL RKNNMTAPCS GVIEVPAYNY
QAIHDIIEQN IFYTHLDLIT AMHNIHSQLF ILLKSLKEDG KSMDLITTQK CDTPCELGSF
LELQRDTLQL SMKRIKEDWC QKVISIVQND LDRFFNFFED DIERFESSRM KKFLRLTNFV
LSAQLRDYVF DELHKLRDFI IPYRYRGSDH FDANEVSGFE PLFIIKIVEK IENGESKIAF
DPPLESVLDG LRQIFYGVLE ETNFIPGIGE TLFPLLTLKP EQYCINNLEL RLEKDTKGLW
KDIQEVITSN FREPEMLLSL YKGYEHCLKL DPVAFATEFY NEHVGKTEMS KLLSIFREEL
ARLKSDSEEV YNISTDNVNF NLLRVDCSGI KNSLYLRTDG TAKELMKLIS KWSTEESSKI
TQSFRDVYSK VQIIPQTAEE LDSLKKYLTD CTKEIERLQS QFATVKSSVH LLSDFSFNLD
MDDFTVFVDT HSWPKKVYGL LEDSTIRLEE DKRKFMDELQ RDINNLLSNL DLYEKIIERF
AVFDDLEKTD QYYEKVKDME SKLEEAKKNS ELYNNRERMF NMNTTEFSKL KDLEKNFKPY
FDLWRIAYEK AQNFPKWNEG TFMNLDAKFI DESLSMWQST LKNLEKNLQP KDETARIITR
QVKKEVVAFL LHMPLINALR KDGLRQRHWQ KIAKLPLEFG KSTAQLDIES INIMNLGDFT
KIGFEEKPIL EKIIDISTLA EKEAEISKNL EKMYSAWKNV NFHLEKYGIT YKLVELDELQ
VLLDEQIVLT QGMRASPYVK ELETEVIAWE NKLLERQDIM TEWIKCQVAY LYLEPIFSSQ
DISAQLPDEA TKFGMVDKMW KNVMEVTNKV KVVAQVVSDE NMRDNFETAN KRLEQIHFGL
KQYLETKRRA FPRFYFLSDD ELLEILSETK DPLRVQPHLK KCFEGIERLE FDKEGKIVAM
LSKQGERIPF QKHVIPAEKN GRVELWLLEI ENEMKGSLRH SIEQSINAYA AIAGNIDKRG
QWILAWPGQV VLTVSQLFWT REVEESIKAQ GVKGVQRYYS KMTKQQKSLI ELVRGENLTA
LQSITLGAMV VIDVHARDVV AGLVKEAVGD ISDFEWQSQL RYYWEDVKDI KDGKNQNQIV
VRQVTAEINY GYEYLGNQER LVITPLTDRC YRTLTGALQL FKGGAPEGPA GTGKTETTKD
LAKAIAKHCV VYNCSDDLTY ESMAQFFRGL ASSGAWSCFD EFNRIELDVL SVVAQQIQTI
QLAVASRATR FFFENMEINM NPTCAIFITM NPGYAGRSEL PDNLKALFRP VAMMVPDYAL
IAEISLFSYG FLEGRKLARK IVSTYRLCSE QLSSQDHYDY GMRAVKAVLV RAGSLKRQFP
DLNEEQLMLR ALNDVNLPKF VSADIPLFNG IIKDLFPTTE HQKVDYSALE NALIQTCAEM
NLQPVPYFIQ KIIQLYEMII VRHGLMLVGF PMSGKTASYI VLKSALEKLG EKINLRVLSP
KAVYGGNLYG YRDTKTKDWK DGVLALHFQK LSTLAEKERK WLMCDGPVDA IWIESMNTVL
DDNKKLCLTS GQIIKMGENM NMMFEVQDLA AASPATVSRC GMVYLEAEKL GSWEPYLASW
LSSKEFPQAL RESKDFEEVT ELFKTLFSTF IPPAIKIFKS HFMAKAYVRV KSDAMLVNSL
INILQSLMDE FADPKVIQNY IKDKSIILEC LFQFALIWSV GIVSVDRVKF DQLYRNMLEE
RARNKVYKFQ IPMPEKPNTL VFDFVFDKKS RKWVEWTASE YAPKFAVSPT EEFRNIIVPT
MDTIRFQFIL KTLLDHGKQP LFVGPTGTGK SEYVKQFLLK LGAGSSEEKE QNNEPKSNFL
PAFINFSATT TPSLIQDILE SKLTRRKQGY IGPPIGKKTI IFVDDLNLPT LDDYGAQPTI
ELLREWQDRG GWHEKFSKQA AFTHVVDVLF VCAMGPPGGG RNEVTPRFIR HFNVIGLTSF
DNQTLTTIFS DIMDWFLSSN SINTISKILA RQIVVGSINL FNNVIEQFRP TPEKSHYTFN
LRDLSKIFQG VCSVGPRLDG SELEKVSLVK IWAHEATRVF HDRLINEQDR ESFYQLLDKE
LQIGEIKYII EETPFDYRNT LFTSLTHDSC ERFKEVVLNK TSNNPKVADI SKLHNILSSK
LEIYNDSHSK MDLVLFNFAI EHIVRIVRII TQPGGNALLI GVGGSGRQSL TKLAAFAAEY
KLFGIQLTRS FTVSEWKDKM KELLISVGGA KKTQTVFLFN DNQIKYQEFL EDISSILNTG
EIPNLFDRDE YKDICESLRA HARNENKGQT PEELYNFFVD RCKECLHIVL CMSPVGENLR
NYLRMFPSLV NCCNIDWFSS WPDQALHAVA QKFIKSINEV TDEELDNNVE IPKDDAFEKD
FDKYVDICAY FHNSSTELSK QFLFKMKRHN YVTPTTYLGL LKNFSSLVKE KRTELQTLRG
KFELGLQRIA ETDKDVNEMQ KELEILQPNL IELSKQNEEL SKKIEIESQN ANEKAKKIEI
EQEEINAQVA KNEQDKVYCM EELAQAEPIW IEAQQKVKDI STAQIAEVRG MQAPPEGVKM
VLKAICIMKG EKVKTIDDGL GNKSKDWWGA SKEMMSRKDF LKYIKNFDMG ALNQEIVGTL
TPILAEMDVE KIKRSSAAAF ALNEWLNALV KYFRVNSVVE PKRLALQEAE QKCAEAARYL
AEKKRELAEI QGMIALKETE RKECEAKKNQ LEHEYQLVSV KLERATKLIG LLEGEKLRWQ
ETLAKIMEQQ TCINGDVILA SGIISYLGAF TSEYRRKILK KWSNKLTQHG IKFSENFTLS
TTLAESMEVR NWIIKEGLPS DDFSVENATI VKRTTNIWPL FIDPQGQAMA WIKEKEKQQK
KDADSLLIIQ MSNPSLIKSL EKAITQGTTT IVEGVGEELD PALEPLLTQR TYYIGGVKYI
NLSDTPTIYN DNFKLYLVTS LSNPHYLPEV STKVQIINFM ITPNGLEEQL LAIVVKIEEK
KLESEKNNLA VQNAKYQEQL KHYQDKILQL LQTSRKIEQK QIETKKTEKD IDTKRNLYRP
VAENASTLFF AICELPNVDP MYQYSLNWYQ DLFTQCVVEL PHEENRSTIQ KIEQLRDFFT
HQMYTRVCRS LFQKDKLLFS LLLCIQLMRK KSLIDHEELK FLLTGTSSVV NSDETTRKLP
EWITQNMYNE LCQIDGMSSV FKNFKQEFFN HLEAWKKVYD SSKPNEEPYP DKWNNLSILQ
KMMVLRIIRP DKLLPAVETF VEKNMDKRFI EPSQFNLKVS YMESTPVKPL IFILSPGVDP
MENLRKFADQ EGVALKSLSL GQGQEEFAIE MINQGSFQGN WVVLQNCHVL LSFLPKLEKI
IDDFARNENK LAANYRLWLT SMPSEKFPVS VLQRGVKITN EPPKGLRANL LQSWNSDPIN
DAKYFTGCKK SREFKKLLFG LTFFHSLVQE RRTFGPLGWN IRYEFNDSDL NISLKQLQMF
LNGKDSNVPF KALTYLTGEC NYGGRVTDDH DRRTLMAILS DFYNEEIIED GYQLSPSGIY
TVPNGDKKHS EYIQTIEKFP SSETPEVFGL HENATISKDQ TESKLMFDAL LTTQQNSAPE
TNDEDDINEN SHETEVLYEL AADILTKLPD NFIIEGDGGA EAKFKVDYHE SMNTVFVQEL
IRFNKLLNAI RNSLQQLQLA LKGLTVMSSD LEQLSKSLSN GKVPLVWSKA SYPSRKPLRT
YIQDLIKRIE FFNNWFIHGK PSVYWLSGFY FTQSFLTGVK QNFARKNKIA IDQIDFEFEI
LDKYYEENIS LPEPECGCYV YGLFLEGAAW DRKKKCLTDP RPKQLFDEMP IIWFKPVDRS
VEQTEPTSSE VKTKSNTYVS PLYRTSERRG TLTTTGHSTN FVMSIKLPMA SDNNEKYWIK
RGCALLCQLD
//
