ID   D2W0L6_NAEGR            Unreviewed;      1124 AA.
AC   D2W0L6;
DT   02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT   02-MAR-2010, sequence version 1.
DT   27-MAR-2024, entry version 46.
DE   SubName: Full=Predicted protein {ECO:0000313|EMBL:EFC37359.1};
GN   ORFNames=NAEGRDRAFT_74902 {ECO:0000313|EMBL:EFC37359.1};
OS   Naegleria gruberi (Amoeba).
OC   Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC   Vahlkampfiidae; Naegleria.
OX   NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN   [1] {ECO:0000313|EMBL:EFC37359.1, ECO:0000313|Proteomes:UP000006671}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NEG-M {ECO:0000313|EMBL:EFC37359.1,
RC   ECO:0000313|Proteomes:UP000006671};
RX   PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA   Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA   Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA   Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA   Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT   "The genome of Naegleria gruberi illuminates early eukaryotic
RT   versatility.";
RL   Cell 140:631-642(2010).
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DR   EMBL; GG738919; EFC37359.1; -; Genomic_DNA.
DR   RefSeq; XP_002670103.1; XM_002670057.1.
DR   AlphaFoldDB; D2W0L6; -.
DR   STRING; 5762.D2W0L6; -.
DR   EnsemblProtists; EFC37359; EFC37359; NAEGRDRAFT_74902.
DR   GeneID; 8853702; -.
DR   VEuPathDB; AmoebaDB:NAEGRDRAFT_74902; -.
DR   eggNOG; KOG4350; Eukaryota.
DR   InParanoid; D2W0L6; -.
DR   OrthoDB; 5472491at2759; -.
DR   Proteomes; UP000006671; Unassembled WGS sequence.
DR   CDD; cd18186; BTB_POZ_ZBTB_KLHL-like; 1.
DR   Gene3D; 1.25.40.420; -; 1.
DR   InterPro; IPR011705; BACK.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   PANTHER; PTHR45774:SF3; BTB (POZ) DOMAIN-CONTAINING PROTEIN 2-LIKE PROTEIN-RELATED; 1.
DR   PANTHER; PTHR45774; BTB/POZ DOMAIN-CONTAINING; 1.
DR   Pfam; PF07707; BACK; 1.
DR   Pfam; PF00651; BTB; 1.
DR   SMART; SM00875; BACK; 1.
DR   SMART; SM00225; BTB; 1.
DR   SUPFAM; SSF54695; POZ domain; 1.
DR   PROSITE; PS50097; BTB; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000006671}.
FT   DOMAIN          580..637
FT                   /note="BTB"
FT                   /evidence="ECO:0000259|PROSITE:PS50097"
FT   REGION          139..173
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          415..442
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          473..509
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          798..862
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        139..172
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        799..813
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        814..837
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1124 AA;  127052 MW;  292140082EF44A72 CRC64;
     MLQLDEEEET TQQLEGILMQ STIPLKSFRG KNIKDYELAL DWCRKFDERE SAVDYLEDLN
     RVKLLKNLLN IKSNLVGLTE LFLTSCFRHV GNSMFSGKQE DYALYTRIIQ DWMNLQLTML
     QQSKETTGVT EKTAFDYLME DDEQEEDEDT TATDDDFNTE GAEEETEINF DEEKSDEPPI
     VNILNMITDM FEKECQFSQL FSNAVSHVDN FPLLEVNTNY YTSSLEYCVK CRHVSFVQVK
     LITSQLEILS EMYSSGISKF FKRLCKIVAS NSRGLETLIL SITDLSSQHL DTFSNLLLEE
     LPNILSNWKQ QSKYVSRIFD TGEISLLDCN LSHYLILLLA ELSNSWTNFV MIQITKKLLS
     SDHDTLHSLI SYLFKHGSKT LLQFLSHWQT LLPNNKLQLF KREQLSMTLP SASTTAVTSS
     SSSSTPSTVT TPSSTLTPTT TSASSTLAST AASASGATSI VVTATTSVTT PTTAVPKLGV
     TGLTTGTSSA SSARSRTISI GKPNSSTTQK DPSFDLLLLQ QYRQDIMKLF ESEIMSDLTI
     VVGPSKLIGS MEEDKPYKTT NSSDKFKNKY YPSDDCSVVE FKVHRAILCA RCEYFSKLFH
     SQMKDCMQGY LKFPDKRPDD FKCLLDFFYS AVININHFNA FGVLKLSDEL GVQIVKEKCI
     EYVKDCVSAD NVFDVLEESS FHNFDELRKY CKEYLEENAN QMFFSESFLN ITKETLIDLL
     KSDKIHLGEL DIFIAVVIWG KHQLIHRMGV QIVSPKSGAN QITVQTHVAS GHQNSVGSTS
     TPTKTVISYG MDGSSKVLSK ENLPDHLKKS GLTESLTERN LSISEQKAPQ PSPELSISEL
     NPKHDDDDET DKDVVDEDDE YEEEVDTLAY STLNPEIMLT NPSASRKQDA DELKQKKERI
     LKIVNYTHDK SFCQQLAKLL YDILHNVRFP TLDPIELYEF VEISKVVPSE LLLEAYRAHS
     LQNRVDLFNS ARLKVREGSL FYVSGVCTDV PISKLKGWCL YYHKPYHHPT SEADIQAIKG
     TRILIGARHK NSSALALCAM GMKQKVLRET FENETTKENG CFFYHWKNHS FGFSGSSLVQ
     LGTADLSEGK DKISWHLTGR GGYRCGSLTS LNESKEWEKM LFYA
//