ID D2W0P3_NAEGR Unreviewed; 821 AA.
AC D2W0P3;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Predicted protein {ECO:0000313|EMBL:EFC37325.1};
GN ORFNames=NAEGRDRAFT_74931 {ECO:0000313|EMBL:EFC37325.1};
OS Naegleria gruberi (Amoeba).
OC Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC Vahlkampfiidae; Naegleria.
OX NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN [1] {ECO:0000313|EMBL:EFC37325.1, ECO:0000313|Proteomes:UP000006671}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEG-M {ECO:0000313|EMBL:EFC37325.1,
RC ECO:0000313|Proteomes:UP000006671};
RX PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT "The genome of Naegleria gruberi illuminates early eukaryotic
RT versatility.";
RL Cell 140:631-642(2010).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; GG738919; EFC37325.1; -; Genomic_DNA.
DR RefSeq; XP_002670069.1; XM_002670023.1.
DR AlphaFoldDB; D2W0P3; -.
DR EnsemblProtists; EFC37325; EFC37325; NAEGRDRAFT_74931.
DR GeneID; 8857269; -.
DR VEuPathDB; AmoebaDB:NAEGRDRAFT_74931; -.
DR eggNOG; KOG4659; Eukaryota.
DR InParanoid; D2W0P3; -.
DR OrthoDB; 5490732at2759; -.
DR Proteomes; UP000006671; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd05819; NHL; 1.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 4.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR013111; EGF_extracell.
DR InterPro; IPR001258; NHL_repeat.
DR PANTHER; PTHR46388; NHL REPEAT-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR46388:SF2; NHL REPEAT-CONTAINING PROTEIN 2; 1.
DR Pfam; PF07974; EGF_2; 1.
DR Pfam; PF01436; NHL; 2.
DR SUPFAM; SSF63829; Calcium-dependent phosphotriesterase; 1.
DR SUPFAM; SSF101898; NHL repeat; 1.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS51125; NHL; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006671};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..821
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003038097"
FT TRANSMEM 802..820
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 161..192
FT /note="NHL"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
FT DOMAIN 725..757
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 747..756
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 821 AA; 86311 MW; 4CF75F3A2C3A2242 CRC64;
MNKSCVTVVL FYCICLLGFL LHVKAEQYET SENPNFSIRY NLTLVTGNGD KRGTGVPYSI
VMTRPVGLAY SQKRNTIYLS EGNLMRKLDL TTGMTYIFAN VENPGLLAFS PNETTLYVCF
PLSNKVQRMD FLPNGTEIFS DFAGNGNSGN TGEGGLAINA QLNQPSGVAV DSNGDVYISD
SGNGLIRKVS ISSGIITKFA GTSQGFAGDG GLAKNAKLSN PRGLNFGPNG DLYIADSDNN
VVRRINSSGI ITTIAGDTTS GYSGDGGDAK LAKMKNPINV IVSKTNEIFI SDADNNVIRK
VSNGNISTIA GNELVGSGFS GDGGDSKNAL ISMVQGFVWI NDELVFGDLV NSIRKISKSG
IISSLTQKLP FTGDGVNVDL SFILYPKGIC VNENTGDIIF SEAYGDTIRK IAKNRIITKI
AGIGSANNSA GVENGQALSV SLHMPSLIQC QPNGDVYVAD YFSNLIRLVS TNGSITNVAG
TGVGGYSGDG GNAKLAKLNA PNSVKVSSSD EIVIADTSNN VIRKVFKNGT IITIAGTIGS
QGYSGDNGLA ISSVLSSPSD VAIAPNGEVF IADWGNHVIR KIDTKGIITT IVGNGTEGNG
GEGFNRPLTA QLKFPKSISL SKDGELFISD YNGIKKLTVK GTIAHIAGVG DDRYVPLTQN
YLSDATTASV FTDQIHIMSN GDLIIGIGNG YDNGKIYKLS KLTCTQPNYS PDSTNTFCLP
SCFGLIADSN NICSGNGSCI STNTCQCKPG YTGAQCQSRI EPTISKQPAY PLTSSSSILP
QKSKGVIGGN SNPRGVASSV CVGMKISGIL LILWVVLMFC F
//
