ID D2W189_NAEGR Unreviewed; 342 AA.
AC D2W189;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=RNA ligase {ECO:0000313|EMBL:EFC37142.1};
GN ORFNames=NAEGRDRAFT_82006 {ECO:0000313|EMBL:EFC37142.1};
OS Naegleria gruberi (Amoeba).
OC Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC Vahlkampfiidae; Naegleria.
OX NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN [1] {ECO:0000313|EMBL:EFC37142.1, ECO:0000313|Proteomes:UP000006671}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEG-M {ECO:0000313|EMBL:EFC37142.1,
RC ECO:0000313|Proteomes:UP000006671};
RX PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT "The genome of Naegleria gruberi illuminates early eukaryotic
RT versatility.";
RL Cell 140:631-642(2010).
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DR EMBL; GG738921; EFC37142.1; -; Genomic_DNA.
DR RefSeq; XP_002669886.1; XM_002669840.1.
DR AlphaFoldDB; D2W189; -.
DR EnsemblProtists; EFC37142; EFC37142; NAEGRDRAFT_82006.
DR GeneID; 8856699; -.
DR VEuPathDB; AmoebaDB:NAEGRDRAFT_82006; -.
DR eggNOG; ENOG502S5WF; Eukaryota.
DR InParanoid; D2W189; -.
DR OrthoDB; 166878at2759; -.
DR Proteomes; UP000006671; Unassembled WGS sequence.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.1490.70; -; 1.
DR Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1.
DR Gene3D; 1.10.10.1810; RNA ligase; 1.
DR InterPro; IPR021122; RNA_ligase_dom_REL/Rnl2.
DR InterPro; IPR041948; Rnl1/2_C_sf.
DR InterPro; IPR040609; Rnl2_C.
DR Pfam; PF09414; RNA_ligase; 1.
DR Pfam; PF18043; T4_Rnl2_C; 1.
DR SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
PE 4: Predicted;
KW Ligase {ECO:0000313|EMBL:EFC37142.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006671}.
FT DOMAIN 42..220
FT /note="RNA ligase"
FT /evidence="ECO:0000259|Pfam:PF09414"
FT DOMAIN 243..329
FT /note="RNA ligase 2 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18043"
SQ SEQUENCE 342 AA; 39530 MW; BA651F2000113BC4 CRC64;
MSAQSISFSK YTKFDNHYRK QYVESIKTQN EEMSKKLNHP MEWYCSEKVH GCNLSFIVDR
VRQSDWRKSL SGELNEQLKL KSVQIYGELF GGLFPNKKPS DAKAIQSGIH YCPHHDFYAF
DVLLGFENGK QSWAVFNNVD PLLDECGFKV RAQPLFKGTL DECLEFDVKF NTKLPETFYP
EIVKERNASW KDLDNICEGV VIKPTKYNIF VETERAVIKK KNEKFLETEA SDKPQQPVKK
EKGDSEELVQ VWNELSRYIT SNRLDNVLSK IGNLTKSNMF PVMKEFSNDA LEEFKLDLER
GALENCKPVS SLSSEDQKKL TKKINDACMV LIKEQLNKPS SE
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