ID D2W1A6_NAEGR Unreviewed; 1060 AA.
AC D2W1A6;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 24-JAN-2024, entry version 46.
DE RecName: Full=adenylate cyclase {ECO:0000256|ARBA:ARBA00012201};
DE EC=4.6.1.1 {ECO:0000256|ARBA:ARBA00012201};
GN ORFNames=NAEGRDRAFT_82012 {ECO:0000313|EMBL:EFC37151.1};
OS Naegleria gruberi (Amoeba).
OC Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC Vahlkampfiidae; Naegleria.
OX NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN [1] {ECO:0000313|EMBL:EFC37151.1, ECO:0000313|Proteomes:UP000006671}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEG-M {ECO:0000313|EMBL:EFC37151.1,
RC ECO:0000313|Proteomes:UP000006671};
RX PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT "The genome of Naegleria gruberi illuminates early eukaryotic
RT versatility.";
RL Cell 140:631-642(2010).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
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DR EMBL; GG738921; EFC37151.1; -; Genomic_DNA.
DR AlphaFoldDB; D2W1A6; -.
DR STRING; 5762.D2W1A6; -.
DR EnsemblProtists; EFC37151; EFC37151; NAEGRDRAFT_82012.
DR VEuPathDB; AmoebaDB:NAEGRDRAFT_82012; -.
DR eggNOG; KOG0618; Eukaryota.
DR InParanoid; D2W1A6; -.
DR OrthoDB; 5483094at2759; -.
DR Proteomes; UP000006671; Unassembled WGS sequence.
DR GO; GO:0043190; C:ATP-binding cassette (ABC) transporter complex; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0006950; P:response to stress; IEA:UniProt.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR007210; ABC_Gly_betaine_transp_sub-bd.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR43081:SF1; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC; 1.
DR PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF04069; OpuAC; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006671};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 681..710
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 729..866
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 103..128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 894..915
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..43
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1060 AA; 121137 MW; C4D2832DE477A291 CRC64;
MESYCSLDED KMMMYSKKPD NSNDNDNSTG TQTSSNCGCI ENNNNDEEVE QQHADQQQQQ
QKIDNDELLM EMILNNILPI NDSSDDSITA ISSSSAKLLS NNYYNTESNN NLSTEEEPSS
STMEEEQATL LADEESANYN IISDSCSTTS SNNSNNTTCS TSTNYNHHKQ QHDDKDDNMQ
CKYNERQRRA LALLMAIRDK YEKNLEKSSK ITTTSGGSLY SSKRMSSTRI TTNTSTTAAC
SSFKTMLKLA LVLIVGVWCV LSFMSDVIIL DDYAASGFHH RYEYLEDDFY EFNHNNIMFV
MAEPPGISPQ ALKEILSRES EIMRQEPIYN DFSFSSLFSM NGLHSLASKA TDFLQRGGFE
SSADVATQCL INSPRKCDNS RKLQLIQFNW LGPTVNANVA KIVLEEMLGI CAEIVTMNVT
HALEEMAEYG TRRSYAMLEF WSESRKFQYD KYVVNDKTIM DVGELGINAK LGWYILGFMK
DEYDLIDEYR EYRTEKAAHY LATNDTYPLG RFIGGAKSWI TFDQQIITNL KLNLQIQYTQ
EENAEDFLIS KIQEANDRKE PVLFYLWYPH QIFKKLSIKN VYLPPSSESC WTSYNQENQL
IDCDYPTELL RKLVSPKLTE DMVLNSFFSK FAYESTDQID ILADIVFQEM SVVDASCKWL
RNNTKRVAYW VSDHNDTSSS VIGIVIASLF VISLFFCTIF ITGLVLYFMY RKNLRKRSLK
YAPRTTPFTL VFTDIQNSTL LWATASETMK SVLSIHNIIM RSNIQKYKGY EAKTAGDSFT
VAFVDPLCAL AFCISVQKDL LLANWPSDSL LLPDMKEVRW NESLIYRGPR IRMGIHAGSD
CNIQIDKKTQ RMEYVGNMVH IANKIEASSV GGRIYVSGAF VQAIKSRLML FDSASNSSNP
KTSKEDVTTS ANTQYYDDSS DKGISKYVQE LNNNLIEFED LGPKQEIEIG GTKIPLFMVK
DFSFARTSWI QQFERVLEES PVEEQKVIGQ KLDLIEEVEK FITDPGSFPA ERKSKLIYDF
INHTSDAELN LPSWNSKYFI DLFDNVFRYI TTQHVNIKEE
//