ID D2W2Q1_NAEGR Unreviewed; 325 AA.
AC D2W2Q1;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Predicted protein {ECO:0000313|EMBL:EFC36684.1};
GN ORFNames=NAEGRDRAFT_75669 {ECO:0000313|EMBL:EFC36684.1};
OS Naegleria gruberi (Amoeba).
OC Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC Vahlkampfiidae; Naegleria.
OX NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN [1] {ECO:0000313|EMBL:EFC36684.1, ECO:0000313|Proteomes:UP000006671}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEG-M {ECO:0000313|EMBL:EFC36684.1,
RC ECO:0000313|Proteomes:UP000006671};
RX PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT "The genome of Naegleria gruberi illuminates early eukaryotic
RT versatility.";
RL Cell 140:631-642(2010).
CC -!- SIMILARITY: Belongs to the G-alpha family.
CC {ECO:0000256|ARBA:ARBA00005804}.
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DR EMBL; GG738927; EFC36684.1; -; Genomic_DNA.
DR RefSeq; XP_002669428.1; XM_002669382.1.
DR AlphaFoldDB; D2W2Q1; -.
DR STRING; 5762.D2W2Q1; -.
DR EnsemblProtists; EFC36684; EFC36684; NAEGRDRAFT_75669.
DR GeneID; 8860745; -.
DR VEuPathDB; AmoebaDB:NAEGRDRAFT_75669; -.
DR eggNOG; KOG0082; Eukaryota.
DR InParanoid; D2W2Q1; -.
DR OrthoDB; 5508353at2759; -.
DR Proteomes; UP000006671; Unassembled WGS sequence.
DR GO; GO:0031683; F:G-protein beta/gamma-subunit complex binding; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR Gene3D; 1.10.400.10; GI Alpha 1, domain 2-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR001019; Gprotein_alpha_su.
DR InterPro; IPR011025; GproteinA_insert.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10218; GTP-BINDING PROTEIN ALPHA SUBUNIT; 1.
DR PANTHER; PTHR10218:SF302; GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-8 SUBUNIT-RELATED; 1.
DR Pfam; PF00503; G-alpha; 1.
DR PRINTS; PR00318; GPROTEINA.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51882; G_ALPHA; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000006671};
KW Transducer {ECO:0000256|ARBA:ARBA00023224}.
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 325 AA; 38433 MW; 9E0E2B8B58AA2D99 CRC64;
MGAQQSHPIP NNHHHQQQQL PSDATNQQQP IRRKIGEGCS LFGTANSGKS TLYYLAKHIL
RKEWFYSSKI EFEHDLQYAC CSMMGKLWSI LEESERKQMK GLILERFEST LDKIEEIIRI
KDWDLFDSFP QVSNFDFCEL LIHVWKIPNM RELYEIRWNE ISLNISQYCN EHKNSINLHS
RLNLQMLENL PEFLENIENP NESFLPLTWC YECTNSSKQF EFRYGYFRDV GGARTERRTW
MQSLASMPET IFLVISLSEI DQYLAEDDSQ TLRIQDTKRM FKFMNSIPEL MDTRKIVLFT
KPDILIKKLQ KGVTVNLGNS FQNET
//
