UniProt: D2W2W7

Database: UniProt
Entry: D2W2W7_NAEGR

LinkDB:  D2W2W7_NAEGR 
Original site:  D2W2W7_NAEGR

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Ontology (1)   
   GO (1)   
Gene (2)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (18)   
   InterPro (7)   
   Pfam (3)   
   PROSITE (5)   
   SMART (3)   
Literature (1)   
   PubMed (1)   
All databases (24)   

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ID   D2W2W7_NAEGR            Unreviewed;      1588 AA.
AC   D2W2W7;
DT   02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT   02-MAR-2010, sequence version 1.
DT   27-MAR-2024, entry version 56.
DE   SubName: Full=Predicted protein {ECO:0000313|EMBL:EFC36621.1};
GN   ORFNames=NAEGRDRAFT_75738 {ECO:0000313|EMBL:EFC36621.1};
OS   Naegleria gruberi (Amoeba).
OC   Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC   Vahlkampfiidae; Naegleria.
OX   NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN   [1] {ECO:0000313|EMBL:EFC36621.1, ECO:0000313|Proteomes:UP000006671}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NEG-M {ECO:0000313|EMBL:EFC36621.1,
RC   ECO:0000313|Proteomes:UP000006671};
RX   PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA   Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA   Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA   Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA   Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT   "The genome of Naegleria gruberi illuminates early eukaryotic
RT   versatility.";
RL   Cell 140:631-642(2010).
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR   EMBL; GG738928; EFC36621.1; -; Genomic_DNA.
DR   RefSeq; XP_002669365.1; XM_002669319.1.
DR   EnsemblProtists; EFC36621; EFC36621; NAEGRDRAFT_75738.
DR   GeneID; 8859949; -.
DR   VEuPathDB; AmoebaDB:NAEGRDRAFT_75738; -.
DR   eggNOG; KOG1225; Eukaryota.
DR   InParanoid; D2W2W7; -.
DR   OrthoDB; 101939at2759; -.
DR   Proteomes; UP000006671; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   CDD; cd00054; EGF_CA; 2.
DR   CDD; cd07440; RGS; 1.
DR   Gene3D; 2.10.25.10; Laminin; 2.
DR   Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR   Gene3D; 2.120.10.30; TolB, C-terminal domain; 2.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR013111; EGF_extracell.
DR   InterPro; IPR000203; GPS.
DR   InterPro; IPR016137; RGS.
DR   InterPro; IPR036305; RGS_sf.
DR   InterPro; IPR044926; RGS_subdomain_2.
DR   PANTHER; PTHR10845; REGULATOR OF G PROTEIN SIGNALING; 1.
DR   PANTHER; PTHR10845:SF192; RGS DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR   Pfam; PF07974; EGF_2; 2.
DR   Pfam; PF01825; GPS; 1.
DR   Pfam; PF00615; RGS; 1.
DR   SMART; SM00181; EGF; 3.
DR   SMART; SM00303; GPS; 1.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF63829; Calcium-dependent phosphotriesterase; 1.
DR   SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR   PROSITE; PS00022; EGF_1; 3.
DR   PROSITE; PS01186; EGF_2; 3.
DR   PROSITE; PS50026; EGF_3; 2.
DR   PROSITE; PS50221; GPS; 1.
DR   PROSITE; PS50132; RGS; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076};
KW   EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006671};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           24..1588
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003038835"
FT   TRANSMEM        1046..1069
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1081..1101
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1140..1162
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1211..1232
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1244..1269
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1344..1366
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1386..1406
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          361..395
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          400..434
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          1425..1550
FT                   /note="RGS"
FT                   /evidence="ECO:0000259|PROSITE:PS50132"
FT   DISULFID        385..394
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   DISULFID        424..433
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ   SEQUENCE   1588 AA;  176270 MW;  1734E0E261FE8D85 CRC64;
     MKVNCHTWLL LSIVLLLFVA VDGQEQKQAS VKYIIKTIGP ISTPDIGMYG ISLYNNELIV
     SDGLNRTIRI FSLESESFSP NKIGNNTSIY TPDGNQNTIC MSTVADSSIF NDTLFYVDRI
     HRIVRKLSLR DWPNSFVSTV AGNYSDFSLS SFTENGSAFS ALKGPNSIFA ISENEFYLID
     KSRVRLVKNG IISLIAGSDL DSSYSGEGVL ATSAILQSPF DIFVRNGKIF LSDTKGVRVI
     NETGYISTLA FTGSPIGGGA LFVTKDETVF VTETYKGRIF RIDKNGTLTM IAGNSTTSYE
     NTDALDSSVS DARGLVFNET SGVIYISEFL KKRIRSLTPS CESGYYLNEF KTMCVTNWCF
     GIESTNSSSV CSGRGECIEM NKCQCQPGFY GNNCGSIGCF GIAANDNRVC SGNGICASSN
     NCTCSPGYTG PNCFIPICFG VSANSPNVCS GNGNCLQPDF CTCTGGYLGI DCSLLVERSL
     NAIGIPQVLV NGVKNNVDFN IVSVELRTSS DLKLTRDECA TANCTISLKY SFMFGSEVIS
     ADENVIGILT KPKNNANLFT LTFNPIISIK IQPTIQSSGN LTFTLLIKPI KDQIIAISQQ
     VILVAPPIRN PMAIVNIQPL SGVALKTSFI IEEVVGAWNF TDSNASRLFL SPLKFAFGFK
     FKNSMIRISE FLTSGRDSVY LPYLNETSLA TSQSLELFVI CLDALGTEYS QSISSVSISA
     NLDDSSEVLK ARMGSIATVF PYDTSLKLRK EVTSSVLVES VNKMTIDISN PSTALENLKQ
     ITLSASSNEV ATAINDKLGN YLNQVNEIYK KEKETLGYVT KQRISDSDLQ TTLTSASNLL
     SFGFSNVSNT CTQLTSVLLL QQSVKLLSES IISTVYSSDL INVTVSTFIK NSNSTKLEKF
     SDISLDSDYI LTKYDGYNKE VGLSLITYTN PLFTSNQTQL TNSKDFTLYL GGKTLPLSEL
     TQPISINFTI LNQTINSLNS SQITCKFWNE TTLQWDSSGC SLSTLQSNGD LICKCTHTTL
     FAAFIENSLN NTATDSLRAA EQLSELYIAQ ISFGVLFFIL SSSILVALIV MRKSQPLASR
     FVTPFIGMFA LVVESGLFLI VQRSILLDTT RNGLILSLKS EGLTESTVIQ LENGNLASNI
     VSNVITIIVN TLTLTAMFSY LYQTSRFHIL KYFYHRLSIK FSLNQNDRTS QLYQKGDKIL
     RVIRIFLSTR AMISIMGIFM TVNLMYWTLW VILVRTSVIT GIEYSYIVSI SFTIMILSLG
     FLICALILLD VIMSLLNSRN ESEMLVDSNE KSTSNLSNSS LSFNKEALQK FDKETAKKMA
     KVPIKRAYDW FIQLDTPLYF RVEMILFIVC FTFLVISQII GLSGLSYKRG DVNSRVNDSI
     SLLFEILYLF SYLLVFGGFA LIVRLVHFIK QKNFRNQSSN EEKDELEQLL SNREGLKLFE
     SFCKKEYSLE NLHLYLELKQ LQELIKANDR IDSVNSLIEE LFTNYIESGS IKEVNIPSET
     RNEFKQMRKS LSELVNSAKN NQEMKSKNEK EIPEAFHEKL QQSISSLQDQ IIINLNDTFS
     RFTTTDEFVF YENSGKTREN LLNDSKLI
//

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