ID D2W386_NAEGR Unreviewed; 452 AA.
AC D2W386;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Predicted protein {ECO:0000313|EMBL:EFC36447.1};
GN ORFNames=NAEGRDRAFT_54368 {ECO:0000313|EMBL:EFC36447.1};
OS Naegleria gruberi (Amoeba).
OC Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC Vahlkampfiidae; Naegleria.
OX NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN [1] {ECO:0000313|EMBL:EFC36447.1, ECO:0000313|Proteomes:UP000006671}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEG-M {ECO:0000313|EMBL:EFC36447.1,
RC ECO:0000313|Proteomes:UP000006671};
RX PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT "The genome of Naegleria gruberi illuminates early eukaryotic
RT versatility.";
RL Cell 140:631-642(2010).
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DR EMBL; GG738930; EFC36447.1; -; Genomic_DNA.
DR RefSeq; XP_002669191.1; XM_002669145.1.
DR AlphaFoldDB; D2W386; -.
DR EnsemblProtists; EFC36447; EFC36447; NAEGRDRAFT_54368.
DR GeneID; 8862688; -.
DR VEuPathDB; AmoebaDB:NAEGRDRAFT_54368; -.
DR InParanoid; D2W386; -.
DR OrthoDB; 1614410at2759; -.
DR Proteomes; UP000006671; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProt.
DR Gene3D; 1.10.287.4070; -; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR002687; Nop_dom.
DR InterPro; IPR036070; Nop_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR PANTHER; PTHR47989; OS01G0750732 PROTEIN; 1.
DR PANTHER; PTHR47989:SF62; OS05G0423500 PROTEIN; 1.
DR Pfam; PF01798; Nop; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR SUPFAM; SSF89124; Nop domain; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000006671};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 88..118
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 191..452
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
SQ SEQUENCE 452 AA; 51136 MW; 6E9CC07814D3F780 CRC64;
MYDIDQDIVL SLNFSTDSTI QITPYPVQKE IGALERSLTL YSEDSQYFFN VSFTFVKCPQ
MFTMDDVVIS GQPAVECIPE QVVLSRDFVI LVAVPTSIAV LILGISIGLF SLYVLNFISV
RMWRLKKKEK AELELEMRII DKKVIFQNSV VSSQSTLSET AKSKQSNNSD LSVPLIEKNE
KPSFIIPIEN IEIVRKLAEG GLGIVYLGKL VGKIDVAIKL LKSTDQGDEF EQEASLLSSL
RHDNILTLFG ICVTSENKYM VTEFAEMGSL DKSLYRARIG EITLPLKNKL SILIATAKGI
EYLHNLTPTV VHRDLHYFLT QLKKMQDSDE TFIIRNIQQY EEVDMPLSAL LLQIVQSYGF
QLKDHSQFDD LERKIRESAI STSGSELSDK ELQEISKLAQ QAEPLLTEKS KIRGALRERM
ILVAPRVYEK LGEVVGARMI QKFGLENMIN QE
//
