ID   D2W3Q8_NAEGR            Unreviewed;       813 AA.
AC   D2W3Q8;
DT   02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT   02-MAR-2010, sequence version 1.
DT   27-MAR-2024, entry version 36.
DE   SubName: Full=Predicted protein {ECO:0000313|EMBL:EFC36306.1};
GN   ORFNames=NAEGRDRAFT_54470 {ECO:0000313|EMBL:EFC36306.1};
OS   Naegleria gruberi (Amoeba).
OC   Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC   Vahlkampfiidae; Naegleria.
OX   NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN   [1] {ECO:0000313|EMBL:EFC36306.1, ECO:0000313|Proteomes:UP000006671}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NEG-M {ECO:0000313|EMBL:EFC36306.1,
RC   ECO:0000313|Proteomes:UP000006671};
RX   PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA   Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA   Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA   Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA   Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT   "The genome of Naegleria gruberi illuminates early eukaryotic
RT   versatility.";
RL   Cell 140:631-642(2010).
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DR   EMBL; GG738933; EFC36306.1; -; Genomic_DNA.
DR   RefSeq; XP_002669050.1; XM_002669004.1.
DR   AlphaFoldDB; D2W3Q8; -.
DR   EnsemblProtists; EFC36306; EFC36306; NAEGRDRAFT_54470.
DR   GeneID; 8862074; -.
DR   VEuPathDB; AmoebaDB:NAEGRDRAFT_54470; -.
DR   InParanoid; D2W3Q8; -.
DR   OrthoDB; 5503585at2759; -.
DR   Proteomes; UP000006671; Unassembled WGS sequence.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:InterPro.
DR   Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR002156; RNaseH_domain.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF00075; RNase_H; 1.
DR   SUPFAM; SSF56219; DNase I-like; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS50879; RNASE_H_1; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000006671}.
FT   DOMAIN          472..603
FT                   /note="RNase H type-1"
FT                   /evidence="ECO:0000259|PROSITE:PS50879"
SQ   SEQUENCE   813 AA;  94439 MW;  7B3E8BE9A79E2502 CRC64;
     MHFLNNPHKR NITNINLIPG VLQWTRFESK GIPINIFTPY LSGRVDDKEN DVEAMNSITN
     AVLTCRDEHV IINGDLNINT INPSNGRDKE WCWLFNLLQL TEYKTNNKTY IRRQQNRITT
     SRLDHIFVSK DIKVIKEELL PPLTSNDHIP FYIDIEFKSH LNWRSYIGKK KREEMIKEIN
     TSNANTFQEL NAEIQNNIAK YGTKVDRLGG SIISSIFKGK IRKLENKIMG KLEDPNVGLD
     EISELQTILK ETHIQSCKEI KEQLTDKYNN SHASHMYQFD RKLHSKEIIW KELPFGEQEI
     LDYFSKKFTT SNQTPTFMPS PSTITSGPRD IGRISYRDVK ETIKRMKSNT PGQDEISLDI
     IKGLKLEKLA LIVEEFNKCL TQGDIPQEWK HEEGGLGVPS IEEFTDRLNL RTLSLIANSN
     NKLVQKAFKF GISHTNDNSN NIFIQWMSIL QKYNLDFKKN HTKFRLKKVN ETNRCFIIHT
     DGSKLAGKTG MGINIYESGG RLSPCKSLSL RINNEYSNNV AEIGAIITAM KLLPNGTTAR
     IHTDSKVAID VLSRKYKGNF LPFKTEFFNI QKEKNISVYI IKVKGHEDKE NIIVDRLAKD
     GTERDKIFDI KSLLTNQYLL MKNDIVIFDC KRMTVNRQLK EMHEAIDSNP NFIPNQSWSS
     INVAYLKSRL SPKTKYQIWR NASNSHIKYT QKKDELNPTC SDCNCPSNLE HYIHECPRLD
     NQRRYCQNRL TEILDRPECS LSPIQEIPFQ YSYVLYFHHS GITFFENEYI DKIPNHNVLK
     KWPEIQAAIS KFIGRAFLIY QIDSKPIYKR SEK
//