ID D2W3R3_NAEGR Unreviewed; 361 AA.
AC D2W3R3;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Predicted protein {ECO:0000313|EMBL:EFC36309.1};
GN ORFNames=NAEGRDRAFT_82262 {ECO:0000313|EMBL:EFC36309.1};
OS Naegleria gruberi (Amoeba).
OC Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC Vahlkampfiidae; Naegleria.
OX NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN [1] {ECO:0000313|EMBL:EFC36309.1, ECO:0000313|Proteomes:UP000006671}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEG-M {ECO:0000313|EMBL:EFC36309.1,
RC ECO:0000313|Proteomes:UP000006671};
RX PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT "The genome of Naegleria gruberi illuminates early eukaryotic
RT versatility.";
RL Cell 140:631-642(2010).
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}.
CC -!- SIMILARITY: Belongs to the FRG1 family.
CC {ECO:0000256|ARBA:ARBA00010878}.
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DR EMBL; GG738933; EFC36309.1; -; Genomic_DNA.
DR RefSeq; XP_002669053.1; XM_002669007.1.
DR AlphaFoldDB; D2W3R3; -.
DR EnsemblProtists; EFC36309; EFC36309; NAEGRDRAFT_82262.
DR GeneID; 8862077; -.
DR VEuPathDB; AmoebaDB:NAEGRDRAFT_82262; -.
DR InParanoid; D2W3R3; -.
DR OrthoDB; 588417at2759; -.
DR Proteomes; UP000006671; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:InterPro.
DR CDD; cd00257; Fascin; 1.
DR Gene3D; 2.80.10.50; -; 3.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR008999; Actin-crosslinking.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR022768; Fascin-domain.
DR InterPro; IPR010414; FRG1.
DR PANTHER; PTHR12928; FRG1 PROTEIN; 1.
DR PANTHER; PTHR12928:SF0; FSHD REGION GENE 1; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR Pfam; PF06268; Fascin; 1.
DR Pfam; PF06229; FRG1; 1.
DR SUPFAM; SSF50405; Actin-crosslinking proteins; 2.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000006671}.
FT DOMAIN 25..60
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 361 AA; 39744 MW; DE64E1EA533099AD CRC64;
MWYQGQQPSW APSGFQIPQH GQDQQLISQA QSTFQQYDKD HSNSMNKKEW KKAAQDIGLA
KEEIKFLFKL VDHAKSKSIS LSDFINVYLF VTGGGMSYPG TNYSGPHGSY TIHSAKHRSL
LANLRSCHSK YFCIEPSGQV VANRDASGAW EAMTLIHISG NDYAFKSAHG KFMCAEPSGE
IIANRDALGP WETFSLVQSG NQVAFKSAHG KFLCAEPSGL VIANRDALGP WEQFQFSLAP
NQSISLRHHH GKLLCAESNH SMVANRDAVG PWEQFTVEHH GAGKNAFRSA HGKLMCAEPS
GLLVANRDAV GPWEQFSVEL HGNGAIALKS EHNTYVCVEP SGDIVVNRSA VGEWERLSFN
L
//
