ID   D2W505_NAEGR            Unreviewed;       278 AA.
AC   D2W505;
DT   02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT   02-MAR-2010, sequence version 1.
DT   27-MAR-2024, entry version 51.
DE   RecName: Full=GPN-loop GTPase 3 {ECO:0000256|ARBA:ARBA00014587, ECO:0000256|RuleBase:RU365059};
GN   ORFNames=NAEGRDRAFT_44893 {ECO:0000313|EMBL:EFC35847.1};
OS   Naegleria gruberi (Amoeba).
OC   Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC   Vahlkampfiidae; Naegleria.
OX   NCBI_TaxID=5762 {ECO:0000313|Proteomes:UP000006671};
RN   [1] {ECO:0000313|EMBL:EFC35847.1, ECO:0000313|Proteomes:UP000006671}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NEG-M {ECO:0000313|EMBL:EFC35847.1,
RC   ECO:0000313|Proteomes:UP000006671};
RX   PubMed=20211133; DOI=10.1016/j.cell.2010.01.032;
RA   Fritz-Laylin L.K., Prochnik S.E., Ginger M.L., Dacks J.B., Carpenter M.L.,
RA   Field M.C., Kuo A., Paredez A., Chapman J., Pham J., Shu S., Neupane R.,
RA   Cipriano M., Mancuso J., Tu H., Salamov A., Lindquist E., Shapiro H.,
RA   Lucas S., Grigoriev I.V., Cande W.Z., Fulton C., Rokhsar D.S., Dawson S.C.;
RT   "The genome of Naegleria gruberi illuminates early eukaryotic
RT   versatility.";
RL   Cell 140:631-642(2010).
CC   -!- FUNCTION: Small GTPase required for proper nuclear import of RNA
CC       polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly
CC       step prior to nuclear import. {ECO:0000256|RuleBase:RU365059}.
CC   -!- SUBUNIT: Binds to RNA polymerase II (RNAPII).
CC       {ECO:0000256|RuleBase:RU365059}.
CC   -!- SIMILARITY: Belongs to the GPN-loop GTPase family.
CC       {ECO:0000256|ARBA:ARBA00005290, ECO:0000256|RuleBase:RU365059}.
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DR   EMBL; GG739004; EFC35847.1; -; Genomic_DNA.
DR   RefSeq; XP_002668591.1; XM_002668545.1.
DR   AlphaFoldDB; D2W505; -.
DR   STRING; 5762.D2W505; -.
DR   EnsemblProtists; EFC35847; EFC35847; NAEGRDRAFT_44893.
DR   GeneID; 8860634; -.
DR   VEuPathDB; AmoebaDB:NAEGRDRAFT_44893; -.
DR   eggNOG; KOG1534; Eukaryota.
DR   InParanoid; D2W505; -.
DR   OMA; HTEDDYI; -.
DR   OrthoDB; 168004at2759; -.
DR   Proteomes; UP000006671; Unassembled WGS sequence.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   CDD; cd17872; GPN3; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR004130; Gpn.
DR   InterPro; IPR030228; Gpn3.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR21231:SF7; GPN-LOOP GTPASE 3; 1.
DR   PANTHER; PTHR21231; XPA-BINDING PROTEIN 1-RELATED; 1.
DR   Pfam; PF03029; ATP_bind_1; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   GTP-binding {ECO:0000256|RuleBase:RU365059};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU365059};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU365059};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006671}.
SQ   SEQUENCE   278 AA;  32100 MW;  231FA69E34C6539E CRC64;
     MGKHAQLVIG PAGSGKSTYC QIQEHGNNTK RIIHVVNLDP AAEEFKYQCA FDIRDLVTLE
     DVMEEFQLGP NGGLVYCMEY LMQNLEDWFS EELSDYENDY LIFDCPGQIE LYSHVPIMQL
     FVKELERRGY RVCCVYCMDV QFIEDVTKYI SGITQALSAM IQFETPHVNI FTKCDTLKGN
     KERSNILEKL KVPDKTELLY ALEKETNPHK RNSSFSKLNH AIVSLIDNFN MVGFLELDIT
     DEESIEYILS YVDMTIQYGE DEEAKEPKEE TEESTQDE
//