ID D2X2J3_GASAC Unreviewed; 833 AA.
AC D2X2J3;
DT 02-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 02-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE SubName: Full=Neuroligin 3a {ECO:0000313|EMBL:ADB12651.1};
GN Name=nlgn3a {ECO:0000313|EMBL:ADB12651.1,
GN ECO:0000313|Ensembl:ENSGACP00000024181.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|EMBL:ADB12651.1};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000024181.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ADB12651.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20034102; DOI=10.1002/dvdy.22196;
RA Rissone A., Sangiorgio L., Monopoli M., Beltrame M., Zucchi I.,
RA Bussolino F., Arese M., Cotelli F.;
RT "Characterization of the neuroligin gene family expression and evolution in
RT zebrafish.";
RL Dev. Dyn. 239:688-702(2010).
RN [3] {ECO:0000313|Ensembl:ENSGACP00000024181.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC -!- SIMILARITY: Belongs to the type-B carboxylesterase/lipase family.
CC {ECO:0000256|ARBA:ARBA00005964}.
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DR EMBL; GQ489224; ADB12651.1; -; mRNA.
DR RefSeq; NP_001254597.1; NM_001267668.1.
DR STRING; 69293.ENSGACP00000024181; -.
DR ESTHER; gasac-d2x2j3; Neuroligin.
DR MEROPS; S09.987; -.
DR Ensembl; ENSGACT00000024229.1; ENSGACP00000024181.1; ENSGACG00000018296.1.
DR GeneID; 100462709; -.
DR KEGG; gat:100462709; -.
DR CTD; 562702; -.
DR eggNOG; KOG1516; Eukaryota.
DR GeneTree; ENSGT00940000159580; -.
DR OMA; QCGHEGA; -.
DR TreeFam; TF326187; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000018296; Expressed in telencephalon and 2 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042043; F:neurexin family protein binding; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007416; P:synapse assembly; IEA:UniProt.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR002018; CarbesteraseB.
DR InterPro; IPR019819; Carboxylesterase_B_CS.
DR InterPro; IPR000460; Nlgn.
DR PANTHER; PTHR43903; NEUROLIGIN; 1.
DR PANTHER; PTHR43903:SF4; NEUROLIGIN-3; 1.
DR Pfam; PF00135; COesterase; 1.
DR PRINTS; PR01090; NEUROLIGIN.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR PROSITE; PS00941; CARBOXYLESTERASE_B_2; 1.
PE 2: Evidence at transcript level;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..42
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 43..833
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015088467"
FT TRANSMEM 690..713
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 47..609
FT /note="Carboxylesterase type B"
FT /evidence="ECO:0000259|Pfam:PF00135"
FT REGION 160..180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 630..676
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 718..738
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 630..651
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 833 AA; 93276 MW; 87A8355CA386B3E7 CRC64;
MWFSLGRGRV PSQNWLGSRG RPGFGVSLWV LSFCWCFPAV GGQNYHPTVN TQYGKLRGVR
VPLPSEILGP VDQYLGVPYA ASPVGEKRFM PPEPPSSWSG IKNATHFAPV CPQNIHNAVP
EIMMPIWFTF NLDIVTTYIQ DQHEDCLYLN IYVPTEDGAH AKKQSEDLSD NDGDEDEDIR
DTGAKPVMVY IHGGSYMEGT GNMIDGSVLA SYGNVIVITL NYRVGVLGFL STGDQAAKGN
YGLLDQIQAL RWISENIGFF GGDSNRITVF GSGIGASCVS LLTLSHHSEG LFHRAIIQSG
SALSSWAVNY QPVKYTRLLA EKVGCNVLDT LDMVDCLRKK SSRELVEQDI QPARYHVAFG
PVIDGDVIPD DPEILMEQGE FLNYDIMLGV NQGEGLRFVE NVVDSEDGVS GNDFDFSVSD
FVDSLYGYPE GKDTLRETIK FMYTDWADRD NPETRRKTLV ALFTDHQWVE PSVVTADLHA
RYGSPTYFYA FYHHCQSLMK PAWSDAAHGD EVPYVFGIPM IGPTDLFPCN FSKNDVMLSA
VVMTYWTNFA KTGDPNKPVP QDTKFIHTKA NRFEEVAWSK YNPQDQLYLH IGLKPRVRDH
YRATKVAFWK HLVPHLYNLH DMFHYTSTTT KVPPPETTQN TLSTKKTWPF NTKRPPMSPA
YNSEDKDSWG DDEETGPLLV ENQRDYSTEL SVTIAVGASL LFLNVLAFAA LYYRKDKRRQ
DSGHGQPSPQ RQTTSNDIGH HAPEEEIMSL QMNQTHHECE AGNSNEGALR LASLPDYTLT
LRRSPDDIPL MTPNTITMIP NSLVGMPNLH PYNTFTTGFN STGLPHSHST TRV
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