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Database: UniProt
Entry: D2ZX21_NEIMU
LinkDB: D2ZX21_NEIMU
Original site: D2ZX21_NEIMU 
ID   D2ZX21_NEIMU            Unreviewed;       933 AA.
AC   D2ZX21;
DT   23-MAR-2010, integrated into UniProtKB/TrEMBL.
DT   23-MAR-2010, sequence version 1.
DT   24-JAN-2024, entry version 76.
DE   RecName: Full=DNA polymerase I {ECO:0000256|ARBA:ARBA00020311, ECO:0000256|RuleBase:RU004460};
DE            EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417, ECO:0000256|RuleBase:RU004460};
GN   Name=polA {ECO:0000256|RuleBase:RU004460,
GN   ECO:0000313|EMBL:EFC88497.1};
GN   ORFNames=NEIMUCOT_05169 {ECO:0000313|EMBL:EFC88497.1};
OS   Neisseria mucosa ATCC 25996.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=546266 {ECO:0000313|EMBL:EFC88497.1, ECO:0000313|Proteomes:UP000003344};
RN   [1] {ECO:0000313|EMBL:EFC88497.1, ECO:0000313|Proteomes:UP000003344}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25996 {ECO:0000313|EMBL:EFC88497.1,
RC   ECO:0000313|Proteomes:UP000003344};
RA   Weinstock G., Sodergren E., Clifton S., Fulton L., Fulton B., Courtney L.,
RA   Fronick C., Harrison M., Strong C., Farmer C., Delahaunty K., Markovic C.,
RA   Hall O., Minx P., Tomlinson C., Mitreva M., Nelson J., Hou S., Wollam A.,
RA   Pepin K.H., Johnson M., Bhonagiri V., Nash W.E., Warren W., Chinwalla A.,
RA   Mardis E.R., Wilson R.K.;
RL   Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: In addition to polymerase activity, this DNA polymerase
CC       exhibits 5'-3' exonuclease activity. {ECO:0000256|RuleBase:RU004460}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC         Evidence={ECO:0000256|ARBA:ARBA00024632,
CC         ECO:0000256|RuleBase:RU004460};
CC   -!- SUBUNIT: Single-chain monomer with multiple functions.
CC       {ECO:0000256|ARBA:ARBA00011541}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-A family.
CC       {ECO:0000256|ARBA:ARBA00007705, ECO:0000256|RuleBase:RU004460}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EFC88497.1}.
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DR   EMBL; ACDX02000008; EFC88497.1; -; Genomic_DNA.
DR   RefSeq; WP_003742916.1; NZ_ACDX02000008.1.
DR   AlphaFoldDB; D2ZX21; -.
DR   STRING; 546266.NEIMUCOT_05169; -.
DR   GeneID; 61323159; -.
DR   eggNOG; COG0258; Bacteria.
DR   eggNOG; COG0749; Bacteria.
DR   Proteomes; UP000003344; Unassembled WGS sequence.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0006261; P:DNA-templated DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd08637; DNA_pol_A_pol_I_C; 1.
DR   CDD; cd06139; DNA_polA_I_Ecoli_like_exo; 1.
DR   CDD; cd09898; H3TH_53EXO; 1.
DR   CDD; cd09859; PIN_53EXO; 1.
DR   Gene3D; 3.30.70.370; -; 1.
DR   Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 2.
DR   Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR   InterPro; IPR020046; 5-3_exonucl_a-hlix_arch_N.
DR   InterPro; IPR002421; 5-3_exonuclease.
DR   InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR   InterPro; IPR019760; DNA-dir_DNA_pol_A_CS.
DR   InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR020045; DNA_polI_H3TH.
DR   InterPro; IPR018320; DNA_polymerase_1.
DR   InterPro; IPR002298; DNA_polymerase_A.
DR   InterPro; IPR008918; HhH2.
DR   InterPro; IPR029060; PIN-like_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   NCBIfam; TIGR00593; pola; 1.
DR   PANTHER; PTHR10133; DNA POLYMERASE I; 1.
DR   PANTHER; PTHR10133:SF27; DNA POLYMERASE NU; 1.
DR   Pfam; PF01367; 5_3_exonuc; 1.
DR   Pfam; PF02739; 5_3_exonuc_N; 1.
DR   Pfam; PF00476; DNA_pol_A; 1.
DR   Pfam; PF01612; DNA_pol_A_exo1; 1.
DR   PRINTS; PR00868; DNAPOLI.
DR   SMART; SM00474; 35EXOc; 1.
DR   SMART; SM00475; 53EXOc; 1.
DR   SMART; SM00279; HhH2; 1.
DR   SMART; SM00482; POLAc; 1.
DR   SUPFAM; SSF47807; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF88723; PIN domain-like; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS00447; DNA_POLYMERASE_A; 1.
PE   3: Inferred from homology;
KW   DNA damage {ECO:0000256|RuleBase:RU004460};
KW   DNA repair {ECO:0000256|RuleBase:RU004460};
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW   ECO:0000256|RuleBase:RU004460};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004460};
KW   DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932,
KW   ECO:0000256|RuleBase:RU004460}; Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW   ECO:0000256|RuleBase:RU004460};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU004460}.
FT   DOMAIN          2..262
FT                   /note="5'-3' exonuclease"
FT                   /evidence="ECO:0000259|SMART:SM00475"
FT   DOMAIN          334..520
FT                   /note="3'-5' exonuclease"
FT                   /evidence="ECO:0000259|SMART:SM00474"
FT   DOMAIN          689..895
FT                   /note="DNA-directed DNA polymerase family A palm"
FT                   /evidence="ECO:0000259|SMART:SM00482"
SQ   SEQUENCE   933 AA;  102201 MW;  7F9C4E530DDFB8D1 CRC64;
     MSKPTLLLVD GSSYLYRAYH AMAQLSAPDG APTGALYGVL NMLRRLRADY VHDYCAVVFD
     AKGKNFRHEM FPDYKATRPP MPDDLRPQAE ALPDLVRLMG WPVLVIPQVE ADDVIGTLAA
     MAGEAGWNVV VSTGDKDMAQ LVNERVTLVN TMSGETLDIE GVKAKFGVRP DQIRDYLALM
     GDKVDNVPGV EKCGPKTAVK WLEAYGSLAG VMEHAAEIKG KVGENLQAAL PQLPLSYDLV
     TIKTDVDLHA ELSDGLESLR RTSPKWSQLA VDFKRWGFRT WLKEAESRMH EAAEGDLFGS
     DTIGEQAALG LPENGGTSSE KIIEHAPAPE KLDYQAVTTE AQFAALLDRL SQADTIGIDT
     ETTSLDAMNA SLVGISIAFQ AGEAVYIPVG HSLTAAPEQL DLQDVLGRLK PHLENPVLKK
     IGQNLKYDQH VFANYGIALN GIAGDAMLAS YIIESHLGHG LDELSERWLG LETITYESLC
     GKGAKQIGFA DVAIEQATEY AAQDADFALR LEAHLRAQMD AKQLEMYEKM ELPVAQVLFE
     MERNGVQIDR AELARQSAEL GAELMKLEQE AYAAAGQLFN LNSPKQLQEI LFDKMGIPTK
     GLKKTAKGGI STNEAVLEQL APDYPLPKII LQNRSLAKLK STYTDKLPEM ISPKDGRVHT
     TYAQAVAITG RLASNNPNLQ NIPIRTAEGR RVRRAFTAPQ GSVIVSADYS QIELRIMAHL
     SGDKTLIAAF QNGEDVHCRT AAEVFGIAPE NVSSEQRRYA KTINFGLIYG MGQYGLAKSL
     GIDNLSAKTF IDRYFARYPG VAEYMQRTKE QAAAQGFVET LFGRRLYLPD IRNKNANARA
     GAERAAINAP MQGTASDLIK RAMIDVSRWL SDDLLQSKLI MQVHDELVLE VPESELDLVK
     TNLPELMADV GKGLLNVPLV AEVGVGENWE EAH
//
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