ID D3E2D3_METRM Unreviewed; 2065 AA.
AC D3E2D3;
DT 23-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 23-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Adhesin-like protein with cysteine protease domain {ECO:0000313|EMBL:ADC46694.1};
GN OrderedLocusNames=mru_0843 {ECO:0000313|EMBL:ADC46694.1};
OS Methanobrevibacter ruminantium (strain ATCC 35063 / DSM 1093 / JCM 13430 /
OS OCM 146 / M1) (Methanobacterium ruminantium).
OC Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC Methanobacteriales; Methanobacteriaceae; Methanobrevibacter.
OX NCBI_TaxID=634498 {ECO:0000313|EMBL:ADC46694.1, ECO:0000313|Proteomes:UP000008680};
RN [1] {ECO:0000313|EMBL:ADC46694.1, ECO:0000313|Proteomes:UP000008680}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35063 / DSM 1093 / JCM 13430 / OCM 146 / M1
RC {ECO:0000313|Proteomes:UP000008680};
RX PubMed=20126622; DOI=10.1371/journal.pone.0008926;
RA Leahy S.C., Kelly W.J., Altermann E., Ronimus R.S., Yeoman C.J.,
RA Pacheco D.M., Li D., Kong Z., McTavish S., Sang C., Lambie S.C.,
RA Janssen P.H., Dey D., Attwood G.T.;
RT "The genome sequence of the rumen methanogen Methanobrevibacter ruminantium
RT reveals new possibilities for controlling ruminant methane emissions.";
RL PLoS ONE 5:E8926-E8926(2010).
CC -!- SIMILARITY: Belongs to the intimin/invasin family.
CC {ECO:0000256|ARBA:ARBA00010116}.
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
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DR EMBL; CP001719; ADC46694.1; -; Genomic_DNA.
DR RefSeq; WP_012955645.1; NC_013790.1.
DR STRING; 634498.mru_0843; -.
DR GeneID; 8770494; -.
DR KEGG; mru:mru_0843; -.
DR PATRIC; fig|634498.28.peg.844; -.
DR eggNOG; arCOG02486; Archaea.
DR eggNOG; arCOG02488; Archaea.
DR eggNOG; arCOG02555; Archaea.
DR eggNOG; arCOG03607; Archaea.
DR HOGENOM; CLU_231200_0_0_2; -.
DR OrthoDB; 78423at2157; -.
DR Proteomes; UP000008680; Chromosome.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd02619; Peptidase_C1; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR003344; Big_1_dom.
DR InterPro; IPR032109; Big_3_5.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR008964; Invasin/intimin_cell_adhesion.
DR InterPro; IPR040528; Lectin-like.
DR InterPro; IPR001434; OmcB-like_DUF11.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR011050; Pectin_lyase_fold/virulence.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR025660; Pept_his_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR PANTHER; PTHR12411:SF741; CATHEPSIN K; 1.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR Pfam; PF16640; Big_3_5; 1.
DR Pfam; PF01345; DUF11; 1.
DR Pfam; PF18560; Lectin_like; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR SMART; SM00634; BID_1; 2.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF49373; Invasin/intimin cell-adhesion fragments; 2.
DR SUPFAM; SSF51126; Pectin lyase-like; 1.
DR PROSITE; PS51127; BIG1; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
DR PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:ADC46694.1};
KW Protease {ECO:0000313|EMBL:ADC46694.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008680}.
FT DOMAIN 1974..2065
FT /note="Big-1"
FT /evidence="ECO:0000259|PROSITE:PS51127"
FT REGION 78..117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1572..1627
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1829..1869
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1833..1869
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2065 AA; 225158 MW; ECCECF3771AC16C8 CRC64;
MKLKYLMFIG LLLIGLLIIP ISFAGDADSY SAYSGDSISL EDDNSYLESN TVLKDSKNSL
QSIDDDCLIG NRTLDDTSYS DSTNSEDLTN PDSTNPDSTN SEDLTNLESS ANTDSSSEIK
TITKSLNDQN TNIKSLNYDE YADYINLNNQ LINYDFAISD SNTIFVNASY TGSTENGSQA
SPYKSIYSAY NYAFGLSSDT RTNVYIAKGV YTVTRRMTIN KNLNLIGEDS LNTIIDCNGN
GAFFISPRRS YTTVYSPLLN IFNLTFTNGR YSSGGAIYIN ESTVNFVNVI FKNNRAEASY
YGSVEGGALY NNKGFVRIYN CLFENNTAND TSDACGGAIY NDMGEMTIMG SQFINNTAKG
ENAAGGAIYD FSGILVIFNS TISKSSLLSN YSMGGGLASW SSHNIFIINS TFDSNEGHGK
YVFGSAIANK AIMMYIENST FSNNLANGTS DKNGTFFHLN GVLDFDNVNF TNNRAINPKE
DILICLEDQF IISEAFSQED IAEILSEMEL SQLPSSYDLR DYNLVTSVKD QKNSGSCWAF
STLAALESYL LKYENTSYDL SENNMKNLIG AYGLNGTDWY DGGNHYMSLA YLLRWSGPVN
ESQDPFNDTS HNSRTFTNIV KQVEDVLYVP LRLNYLDIDQ IKAAILKYGA LYTTLCSDDS
FDNNPDYYCD VISISNHAIT IVGWNDSYSA DNFAVRPPGD GAFIIKNSWG PSEGYDGYWY
VSYYDKTLAG YGYDAIAAMA FTSVANASTY KNNYQYDTLG NTFESIGYGC STAWIANQFT
ALNNNPLAAF GLYTYGSSSY LVNITVNGIS RLVQEGNVKG AGYHTIKLDD VVELLSGDIF
KIIVKLSTPD SNYPVAIESK RSDYSSRANS NPGESFISFD GQNWQDLYEV GDILKFYMYM
NNKTFTEPNI CLKAYTIGPS DVHLHARANA TTYTQGDTVE IKITVSNEGA TVNDLNISMK
WNSSFFLKSF TKLNGEFDST KKIWHFDTFS EGQSSTLTLV FTMRGNNDVA SLSYDYNYSG
FNPGDANTTQ VLNLYYGSLT KFVEVPNVST SVKSGDVVDI QLTDLQSIGI SDKQIVISLL
ESDNEYLFEN VTLITNGSGQ AGFVLDLLEG NYVFLASFAG DDSYMSSNVT FNVSVSKSNT
SISLDNLDPS NITVFSKSGD VINFTLSDGI NNLSDKNIVI SLIESDNDYL FENLTLITNG
SGQAGFVLDL LEGNYVFLAS FAEDGYYKAS NLTFYLNVLR RASSMEFDSS SLIYNGSNWI
SLSQSNDLIE FILSNQTGPL ADKTIILTVE DLNSVDLAEN PLIYNLTTGP NGIASFNLNL
TKSNYEIIAS YLGDECYSPC EFGFNLSVLK RNAPHIVADD IAINSSNPYQ AHLLDDDFNP
IANQSLLFAF AKKDSQDLFN YSAITNERGI AIIDLSDIES GDYNLLIAFE SNDLYDDSIL
EIDVSVVNDS LNGDNGTNDT GNGTNGTDNS SKINTLFKID MSDLTVSANV DKTIEFALLD
ESLNPLADKT LNLTIVDLDE DTELITDSDG IASCVLNLDE GVYEFVLSFS GDENYSPSRL
IFNLSVSKAD NGTSPGGDNG TSPGGDNATN GTDPSGGNGT APINDNGTNG TDPSGGNGTS
PGDNGTESSK INTLFKIDLS NLNIFANLEK VIEFELLDES LNPLSNKTVG LTISNLDGVS
LITDSNGIAS CPINLDEGVY EFALKFLGDD DYSESAMIFN LSVSKRIAQL LSGETLINLS
SEKREYDVYL VDDKLSPLAN ETILFALSSM DGQVLFNYVV KTNDEGKASL SGLAKLNESN
YIVKTEFASN DFFEGAELIK TITLIKDAPN GDDANDTNGT GNQTDNGTDT GNKTDNGTDT
NGTNGSDVPV SRKATKIIYE DMVTQSVVPD VDGRIGDYFY VTLVDGNNNP LANKEVKIGF
NGRIYNRTTN ATGGVKLQIN LKMPFTYTFA ICFLGDDDYN ASFEVAKITV NKKKMSLTAP
SKTYKSTAKT KALTATLKDN NNKAVANKKI TFTVNGKTYS ATTNSKGVAS VNVSLSSKKT
YSFTAKFAGD ACYGAVTKSG KITIK
//
