ID D3EFK1_GEOS4 Unreviewed; 676 AA.
AC D3EFK1;
DT 23-MAR-2010, integrated into UniProtKB/TrEMBL.
DT 23-MAR-2010, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=NHL repeat containing protein {ECO:0000313|EMBL:ACX65418.1};
GN OrderedLocusNames=GYMC10_3162 {ECO:0000313|EMBL:ACX65418.1};
OS Geobacillus sp. (strain Y412MC10).
OC Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Paenibacillus.
OX NCBI_TaxID=481743 {ECO:0000313|EMBL:ACX65418.1, ECO:0000313|Proteomes:UP000002381};
RN [1] {ECO:0000313|Proteomes:UP000002381}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Y412MC10 {ECO:0000313|Proteomes:UP000002381};
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Saunders E., Brettin T., Detter J.C.,
RA Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G.,
RA Brumm P., Mead D.;
RT "Complete sequence of Geobacillus sp. Y412MC10.";
RL Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ACX65418.1, ECO:0000313|Proteomes:UP000002381}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Y412MC10 {ECO:0000313|EMBL:ACX65418.1,
RC ECO:0000313|Proteomes:UP000002381};
RX PubMed=23408395; DOI=10.4056/sigs.2605792;
RA Mead D.A., Lucas S., Copeland A., Lapidus A., Cheng J.F., Bruce D.C.,
RA Goodwin L.A., Pitluck S., Chertkov O., Zhang X., Detter J.C., Han C.S.,
RA Tapia R., Land M., Hauser L.J., Chang Y.J., Kyrpides N.C., Ivanova N.N.,
RA Ovchinnikova G., Woyke T., Brumm C., Hochstein R., Schoenfeld T., Brumm P.;
RT "Complete Genome Sequence of Paenibacillus strain Y4.12MC10, a Novel
RT Paenibacillus lautus strain Isolated from Obsidian Hot Spring in
RT Yellowstone National Park.";
RL Stand. Genomic Sci. 6:381-400(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP001793; ACX65418.1; -; Genomic_DNA.
DR RefSeq; WP_015735405.1; NC_013406.1.
DR AlphaFoldDB; D3EFK1; -.
DR STRING; 481743.GYMC10_3162; -.
DR KEGG; gym:GYMC10_3162; -.
DR HOGENOM; CLU_024978_0_0_9; -.
DR Proteomes; UP000002381; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd05819; NHL; 1.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 2.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR001258; NHL_repeat.
DR InterPro; IPR011041; Quinoprot_gluc/sorb_DH.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR006977; Yip1_dom.
DR PANTHER; PTHR24104; E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED; 1.
DR PANTHER; PTHR24104:SF25; GLYCOPROTEIN, PUTATIVE-RELATED; 1.
DR Pfam; PF04893; Yip1; 1.
DR SUPFAM; SSF50952; Soluble quinoprotein glucose dehydrogenase; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS51125; NHL; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..676
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003043036"
FT TRANSMEM 432..450
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 506..527
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 539..558
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 570..590
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 602..622
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 634..658
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 103..133
FT /note="NHL"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
FT DOMAIN 482..651
FT /note="Yip1"
FT /evidence="ECO:0000259|Pfam:PF04893"
SQ SEQUENCE 676 AA; 76353 MW; 35DA9B7A22302699 CRC64;
MKKKTVGRWV LLVVIACFLL VQIPAPAMAA APYQTGTEGP GGMIVGTQTA YEPDGMIRLD
INQPADLFYD EPTGKLYIAD PGNARIVVYE ENNAPQTIGE DVLSNPSGVY VAADRLVYVA
DYGLKQIVVF DEQGKLVKQF GRPEEPIYGK KNDFAPKKVA VDKRGNIYVI SEGSINGVVQ
LNNEGHFLGY VGANRTSLSM KMLIQRFIFT EGQKAQLFKS TPPSPTSIVL DYQGLLYTVT
NGISSDGIKK LNIVGDNILS SSSWTSEAMV DIDVDAGGNI YTVDVNGLIC VYDSFGNLLF
MFGGWDDKYE RQGLFKSASA IDVTDSGRTL YVADKERNVI NRYSITPFGT KVYEGVDQYK
QGLYVQSEDI WKEILKMNSY FILSYKSLAE SYFKQNQNGK ALESFRMAED KEGYSDAFWK
IRNDWLQQNI NVVVYTVFAI IVAGYVIRIL HRRYRVLQPL VRLRNRVADI KLVKEIGFMF
YFLKHPIDAV QELKEHKRAT VRSATVLYVW MLLLQVILVY AKGYLFASGD PDQMDLLPIM
LTSAVPLLFW VVMNYMVSTI SDGEGKLSEV YIGTVYALSP YLIFALPIAL ISNVLTYNEK
FVYDYSMMLI QGWSLLLVCI MVKELHDYTF RQTVRNLFLT VFGIVLAALV IFLLVLLFNQ
EVEFIQTIIQ EMRNRA
//
