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Database: UniProt
Entry: D3LTB5_9FIRM
LinkDB: D3LTB5_9FIRM
Original site: D3LTB5_9FIRM 
ID   D3LTB5_9FIRM            Unreviewed;       553 AA.
AC   D3LTB5;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   20-APR-2010, sequence version 1.
DT   28-FEB-2018, entry version 32.
DE   SubName: Full=Acetolactate synthase {ECO:0000313|EMBL:EFD94454.1};
GN   ORFNames=HMPREF0889_0513 {ECO:0000313|EMBL:EFD94454.1};
OS   Megasphaera genomosp. type_1 str. 28L.
OC   Bacteria; Firmicutes; Negativicutes; Veillonellales; Veillonellaceae;
OC   Megasphaera.
OX   NCBI_TaxID=699218 {ECO:0000313|EMBL:EFD94454.1, ECO:0000313|Proteomes:UP000003242};
RN   [1] {ECO:0000313|Proteomes:UP000003242}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=28L {ECO:0000313|Proteomes:UP000003242};
RA   Madupu R., Durkin A.S., Torralba M., Methe B., Sutton G.G.,
RA   Strausberg R.L., Nelson K.E.;
RT   "Sequence of Clostridiales genomosp. BVAB3 str. UPII9-5.";
RL   Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the TPP enzyme family.
CC       {ECO:0000256|RuleBase:RU362132}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EFD94454.1}.
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DR   EMBL; ADGP01000009; EFD94454.1; -; Genomic_DNA.
DR   RefSeq; WP_007390787.1; NZ_ADGP01000009.1.
DR   STRING; 699218.HMPREF0889_0513; -.
DR   EnsemblBacteria; EFD94454; EFD94454; HMPREF0889_0513.
DR   eggNOG; ENOG4105C7K; Bacteria.
DR   eggNOG; COG0028; LUCA.
DR   OrthoDB; POG091H02KO; -.
DR   Proteomes; UP000003242; Unassembled WGS sequence.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR   InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR   InterPro; IPR000399; TPP-bd_CS.
DR   InterPro; IPR011766; TPP_enzyme-bd_C.
DR   Pfam; PF02775; TPP_enzyme_C; 1.
DR   Pfam; PF00205; TPP_enzyme_M; 1.
DR   Pfam; PF02776; TPP_enzyme_N; 1.
DR   SUPFAM; SSF52467; SSF52467; 1.
DR   SUPFAM; SSF52518; SSF52518; 2.
DR   PROSITE; PS00187; TPP_ENZYMES; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000003242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000003242};
KW   Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT   DOMAIN        9    175       TPP_enzyme_N. {ECO:0000259|Pfam:PF02776}.
FT   DOMAIN      197    327       TPP_enzyme_M. {ECO:0000259|Pfam:PF00205}.
FT   DOMAIN      385    531       TPP_enzyme_C. {ECO:0000259|Pfam:PF02775}.
SQ   SEQUENCE   553 AA;  61158 MW;  26433DF85FFE71A3 CRC64;
     MAESKQTRTT ADLLVECLEE EGVHYIFGIP GEENLAVMEA ISRSKIEFIT VRHEQGAAFM
     ADVYGRLTGK AGVCMATLGP GATNLITGVA DADCDGAPLV AISGQVGTDK MHITAHQYLD
     LRAMFEPITR RAYTVVRPDT VAEITRLAFK YAEREKPGAT FIDLPVNISK MPVGEQERPL
     RHKTILAEKA LDEQIMAAAH AVSYAKNPVI LAGSGVIRSG ASEVLTQFAE KLKIPVINTM
     MAKGAIPFDN PYSLWTTGIP MADYQTKVLE KASVVIAIGY DIIEYAPAKW HANNADIIHI
     DTMPADINKT YQPIVEVVGN IPDSLTRIME HAARLQEPTY ALSIRRRMID EHNSYADDKA
     FPVKPQKALI DCRKVMGEDD IVISDVGANK VWIARHYNCY KPNSCIISNG FATMGIAVPG
     AIAAKLVHPD KKVLAITGDA GFMMNCQEFE TAHRLGTNFV TLIFNDCSYG LIKWKQDMQY
     GHHHYVDFTN PDFVTFAKSV GAVGYRINST EELLPTLIKA FKQPKPVIID CPIDYRENLK
     LTDHLRELMK TID
//
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