ID D3LV63_9FIRM Unreviewed; 667 AA.
AC D3LV63;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 20-APR-2010, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE SubName: Full=Penicillin-binding protein, transpeptidase domain protein {ECO:0000313|EMBL:EFD93991.1};
GN ORFNames=HMPREF0889_0396 {ECO:0000313|EMBL:EFD93991.1};
OS Megasphaera genomosp. type_1 str. 28L.
OC Bacteria; Bacillota; Negativicutes; Veillonellales; Veillonellaceae;
OC Megasphaera.
OX NCBI_TaxID=699218 {ECO:0000313|EMBL:EFD93991.1, ECO:0000313|Proteomes:UP000003242};
RN [1] {ECO:0000313|Proteomes:UP000003242}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=28L {ECO:0000313|Proteomes:UP000003242};
RA Madupu R., Durkin A.S., Torralba M., Methe B., Sutton G.G.,
RA Strausberg R.L., Nelson K.E.;
RT "Sequence of Clostridiales genomosp. BVAB3 str. UPII9-5.";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFD93991.1}.
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DR EMBL; ADGP01000020; EFD93991.1; -; Genomic_DNA.
DR RefSeq; WP_007391272.1; NZ_ADGP01000020.1.
DR AlphaFoldDB; D3LV63; -.
DR STRING; 699218.HMPREF0889_0396; -.
DR eggNOG; COG0768; Bacteria.
DR OrthoDB; 9770103at2; -.
DR Proteomes; UP000003242; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR CDD; cd06575; PASTA_Pbp2x-like_2; 1.
DR Gene3D; 3.30.450.330; -; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005543; PASTA_dom.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF1; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE FTSI; 1.
DR Pfam; PF03793; PASTA; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
DR SUPFAM; SSF54184; Penicillin-binding protein 2x (pbp-2x), c-terminal domain; 1.
DR PROSITE; PS51178; PASTA; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..36
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 608..667
FT /note="PASTA"
FT /evidence="ECO:0000259|PROSITE:PS51178"
SQ SEQUENCE 667 AA; 72900 MW; C57F43988A6490FE CRC64;
MRIDNKDTQT EQIRKRSAGI WLLLGVVFVA VLVRMVDLQI VEGAKMTQYI DQQAETDRQL
QSPRGTIFDR NGRVLAISEI AKSLYADPNM LRQDVKDPEK HVSVEKLSAA LAPYVGMDAK
EVQERLQRDT GFVWLARTMD HTKYEAVRQI IKQYKLSSLR FVDENRRYYP NGDMAAQLIG
FVGENDKGLD GVEMVLDDVI RGSIQTVKTV MDPDKVPILD SALHSMLPHK ERSVRLTIDS
TIQFVAEKSL DGIMARNHPE GAAIIVMDPK TGEILAMASR PNFDPNDFGK GNAEAYKNRA
VVNLYEPGST FKPIMASAAV DSGAWGLQTE YLDTGAIQVR DRVIHNWDKS GMGRVTLREI
LKFSINTGMV NIALHTGGKT LTAYAKRFGF GKETGIDLPG EGTGILFNAA TMSDVDTAVM
GIGQGIAVTP LQMVQAFGAL ANGGRMMKPF VIKEIDNPDG SVYKKTTPTL VSTPIKAGTA
AAISRILSEE ISSGGGQNAK IAGYTFCGKT GTAQRLNKAG TGYAPNQHIA SFIGFGPLED
PQYVVLIVVD NPVGVYYGAQ VVAPVFKEMM TEIVRFKGVK PSHPTEAERP FIPAEPIKKR
EIPAVIKTEK GIILPSFTGW DTREVNTWLN QAGLCFVPRG MGKAVYQNPE AGAPVRAGST
VIVTFTR
//
